Metabolite‐based genome‐wide association studies enable the dissection of the genetic bases of flavonoids, betaine and spermidine in wolfberry (Lycium) DOI Creative Commons
Jianhua Zhao, Yuhui Xu,

Haoxia Li

и другие.

Plant Biotechnology Journal, Год журнала: 2024, Номер 22(6), С. 1435 - 1452

Опубликована: Янв. 9, 2024

Summary Wolfberry is a plant with medicinal and food values. However, its bioactive ingredients the corresponding genetic bases have not been determined. Here, we de novo generated chromosome‐level genome assembly for wolfberry, yielding sequence of ~1.77 Gb contig N 50 50.55 Mb 39 224 predicted gene models. A variation map, using 307 re‐sequenced accessions, was called based on this assembly. Furthermore, fruit metabolome these accessions profiled 563 annotated metabolites, which separated Lycium barbarum L. non‐ The flavonoids, coumarins, alkaloids nicotinic acid contents were higher in former than latter. metabolite‐based genome‐wide association study mapped 156 164 significant single nucleotide polymorphisms to 340 metabolites. This included 19 219 unique lead 1517 loci, three betaine spermidine, highlighted. Two candidate genes, LbUGT ( evm.TU.chr07.2692 ) LbCHS evm.TU.chr07.2738 ), non‐synonymous mutations, associated flavonoids content. structural that interacts nearby MYB transcription factor evm.TU.chr07.2726 both ruthenicum . Thus, genes might be involved biosynthesis/metabolism flavonoids. LbSSADH evm.TU.chr09.627 identified as possibly participating biosynthesis/metabolism. Four lycibarbarspermidines (E–G O) identified, only O content varieties varieties. evm.TU.chr07.2680 an acetyl‐CoA‐benzylalcohol acetyltransferase, suggesting it spermidine biosynthesis. These results provide novel insights into specific metabolite profile

Язык: Английский

Nutritional composition and bioactive potential of watermelon seeds: a pathway to sustainable food and health innovation DOI Creative Commons

Jasia Nissar,

Urba Shafiq Sidiqi,

Aamir Hussain Dar

и другие.

Sustainable Food Technology, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Watermelon ( Citrullus lanatus ), belonging to the Cucurbitaceae family, is a globally cultivated fruit with significant commercial value.

Язык: Английский

Процитировано

3

Antiviral Activity of Carrageenans and Processing Implications DOI Creative Commons
Milena Álvarez-Viñas, Sandra Souto, Noelia Flórez‐Fernández

и другие.

Marine Drugs, Год журнала: 2021, Номер 19(8), С. 437 - 437

Опубликована: Июль 30, 2021

Carrageenan and carrageenan oligosaccharides are red seaweed sulfated carbohydrates with well-known antiviral properties, mainly through the blocking of viral attachment stage. They also exhibit other interesting biological properties can be used to prepare different drug delivery systems for controlled administration. The most active forms λ-, ι-, κ-carrageenans, degree sulfation position being determined in their properties. obtained from sustainable worldwide available resources influence manufacturing on composition, structure, should considered. This review presents a survey relation processing conditions, particularly those assisted by intensification technologies during extraction stage, discusses possibility further chemical modifications.

Язык: Английский

Процитировано

73

Antioxidant action of deprotonated flavonoids: Thermodynamics of sequential proton-loss electron-transfer DOI

Monika Biela,

Ján Rimarčík,

Erika Senajová

и другие.

Phytochemistry, Год журнала: 2020, Номер 180, С. 112528 - 112528

Опубликована: Окт. 3, 2020

Язык: Английский

Процитировано

71

Reactive Oxygen Species as a Link between Antioxidant Pathways and Autophagy DOI Creative Commons

Dan Li,

Zongxian Ding,

Kaili Du

и другие.

Oxidative Medicine and Cellular Longevity, Год журнала: 2021, Номер 2021(1)

Опубликована: Янв. 1, 2021

Reactive oxygen species (ROS) are highly reactive molecules that can oxidize proteins, lipids, and DNA. Under physiological conditions, ROS mainly generated in the mitochondria during aerobic metabolism. pathological excessive disrupt cellular homeostasis. High levels of result severe oxidative damage to machinery. However, a low/mild level could serve as signal trigger cell survival mechanisms. To prevent cope with biomolecules, cells have developed various antioxidant detoxifying Meanwhile, initiate autophagy, process self-clearance, which helps reduce by engulfing degrading oxidized substance. This review summarizes interactions among ROS, pathways. The effects natural phytochemicals on autophagy induction, antioxidation, dual-function also discussed.

Язык: Английский

Процитировано

67

Prevention and Treatment of Cardiovascular Diseases with Plant Phytochemicals: A Review DOI Open Access
Rakesh Kumar Bachheti, Limenew Abate Worku, Yilma Hunde Gonfa

и другие.

Evidence-based Complementary and Alternative Medicine, Год журнала: 2022, Номер 2022, С. 1 - 21

Опубликована: Июль 4, 2022

Cardiovascular diseases (CVDs) are the world's leading killers, accounting for 30% deaths. According to WHO report, CVDs kill 17.9 million people per year, and there will be 22.2 deaths from CVD in 2030. The death rates rise as get older. Regarding gender, rate of women by (51%) is higher than that men (42%). To decrease prevent CVD, most rely on traditional medicine originating plant (phytochemicals) addition or preference commercially available drugs recover their illness. therapy efficacy 92 plants, including 15 terrestrial examined. Some medicinal plants well known treat are,

Язык: Английский

Процитировано

63

Structure–function relationship of terpenoid glycosyltransferases from plants DOI
Elisabeth Kurze, Matthias Wüst,

Jieren Liao

и другие.

Natural Product Reports, Год журнала: 2021, Номер 39(2), С. 389 - 409

Опубликована: Сен. 6, 2021

The spatial size of the catalytic centre and a large hydrophobic pocket in active site affect enzymatic activity substrate preference uridine diphosphate–sugar-dependent terpenoid glycosyltransferases plants.

Язык: Английский

Процитировано

62

Hydroxylation decoration patterns of flavonoids in horticultural crops: chemistry, bioactivity, and biosynthesis DOI Creative Commons
Yilong Liu,

Jiafei Qian,

Jiajia Li

и другие.

Horticulture Research, Год журнала: 2022, Номер 9

Опубликована: Янв. 1, 2022

Abstract Flavonoids are the most widespread polyphenolic compounds and important dietary constituents present in horticultural crops such as fruits, vegetables, tea. Natural flavonoids responsible for quality traits, food colors beneficial antioxidants, numerous investigations have shown that intake of can reduce incidence various non-communicable diseases. Analysis thousands reported so far has different hydroxylation modifications affect their chemical properties nutritional values. These diverse be classified based on patterns B, C, A rings multiple structure–activity analyses decoration at specific positions markedly enhances bioactivities. This review focuses current knowledge concerning catalyzed by several types hydroxylase enzymes. Flavonoid 3′-hydroxylase (F3′H) flavonoid 3′5′-hydroxylase (F3′5′H) enzymes B ring flavonoids. Flavanone 3-hydroxylase (F3H) is key C ring, while flavone 6-hydroxylase (F6H) 8-hydroxylase (F8H) ring. hydroxylases biosynthesis pathway promising targets future bioengineering plants mass production with designated high importance. In addition, places may help render ready degradation, catabolic turnover open door new lines inquiry.

Язык: Английский

Процитировано

62

Root metabolome of plant–arbuscular mycorrhizal symbiosis mirrors the mutualistic or parasitic mycorrhizal phenotype DOI
Sukhmanpreet Kaur, Barbara J. Campbell, Vidya Suseela

и другие.

New Phytologist, Год журнала: 2022, Номер 234(2), С. 672 - 687

Опубликована: Янв. 28, 2022

The symbiosis of arbuscular mycorrhizal fungi (AMF) with plants, the most ancient and widespread association, exhibits phenotypes that range from mutualism to parasitism. However, we still lack an understanding cellular-level mechanisms differentiate regulate these phenotypes. We assessed modulation in growth parameters root metabolome two sorghum accessions inoculated AMF species (Rhizophagus irregularis, Gigaspora gigantea), alone a mixture under phosphorus (P) limiting conditions. Rhizophagus irregularis exhibited mutualistic phenotype increased P uptake plant growth. This positive outcome was associated facilitatory metabolic response including higher abundance organic acids specialized metabolites critical maintaining functional symbiosis. G. gigantea parasitic led depression resulted inhibitory responses p-hydroxyphenylacetaldoxime antifungal properties. These findings suggest differential plant-AMF could be regulated by or reflected changes arises interaction specific species. A symbiotic association prevailed when host plants were exposed AMF. Our results provide metabolome-level landscape highlight importance identity both crop genotypes facilitating

Язык: Английский

Процитировано

53

Evolution and function of red pigmentation in land plants DOI Creative Commons
Kevin M. Davies, Marco Landi, John W. van Klink

и другие.

Annals of Botany, Год журнала: 2022, Номер 130(5), С. 613 - 636

Опубликована: Сен. 7, 2022

Abstract Background Land plants commonly produce red pigmentation as a response to environmental stressors, both abiotic and biotic. The type of pigment produced varies among different land plant lineages. In the majority species they are flavonoids, large branch phenylpropanoid pathway. Flavonoids that can confer colours include 3-hydroxyanthocyanins, 3-deoxyanthocyanins, sphagnorubins auronidins, which predominant pigments in flowering plants, ferns, mosses liverworts, respectively. However, some have lost capacity for anthocyanin biosynthesis nitrogen-containing betalain instead. Some terrestrial algal also an stress response, these carotenoid phenolic pigments. Scope this review, we examine: triggers induce non-reproductive tissues; theories on functions stress-induced pigmentation; evolution biosynthetic pathways; structure–function aspects types. We compare data with those algae, discuss possible explanations lack hornwort lineage plants. Conclusions evidence suggests pathways evolved numerous times provide compounds colour screen damaging photosynthetically active radiation but secondary specific benefits particular lineage.

Язык: Английский

Процитировано

53

Biochemistry and Molecular Basis of Intracellular Flavonoid Transport in Plants DOI Creative Commons
Boas Pucker, Dirk Selmar

Plants, Год журнала: 2022, Номер 11(7), С. 963 - 963

Опубликована: Апрель 1, 2022

Flavonoids are a biochemically diverse group of specialized metabolites in plants that derived from phenylalanine. While the biosynthesis flavonoid aglycone is highly conserved across species and well characterized, numerous species-specific decoration steps their relevance remained largely unexplored. The takes place at cytosolic side endoplasmatic reticulum (ER), but accumulation various flavonoids was observed central vacuole. A universal explanation for subcellular transport has eluded researchers decades. Current knowledge suggests glutathione S-transferase-like protein (ligandin) protects anthocyanins potentially proanthocyanidin precursors during to ABCC transporters lower extend MATE sequester into Glycosides specific sequestered through transporters. P-ATPase tonoplast other proteins generate proton gradient required MATE-mediated antiport. Vesicle-mediated ER vacuole considered as an alternative or additional route.

Язык: Английский

Процитировано

43