Anti-Inflammatory and Cytotoxic Compounds Isolated from Plants of Euphorbia Genus

Molecules, Год журнала: 2024, Номер 29(5), С. 1083 - 1083

Опубликована: Фев. 29, 2024

Euphorbia is a large genus of the Euphorbiaceae family. Around 250 species have been studied chemically and pharmacologically; different compounds isolated from these species, especially diterpenes triterpenes. Several reports show that several anti-inflammatory activity, which can be attributed to presence diterpenes, such as abietanes, ingenanes, lathyranes. In addition, it was found some anti-cancer activity. this review, we included with or cytotoxic effects published 2018 September 2023. The databases used for review were Science Direct, Scopus, PubMed, Springer, Google Scholar, using keywords 68 studies collected analyzed regarding activities 264 obtained 36 genus. in are terpenes (95%), 68% types triterpenes (approximately 15%).

Язык: Английский

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A Comprehensive Review of the Phytochemistry, Pharmacology and Other Applications of Euphorbiae Humifusae Herba

Molecules, Год журнала: 2025, Номер 30(5), С. 1094 - 1094

Опубликована: Фев. 27, 2025

Euphorbiae Humifusae Herba (EHH) is a globally distributed plant commonly utilized in traditional Chinese medicine (TCM) and health food within China. The dried aerial parts of EHH are well-recognized as foods for the management diarrhea other intestinal diseases. Known its therapeutic effects, such heat-clearing, detoxification, blood cooling, hemostasis, dampness, elimination, jaundice relief, has yielded 197 bioactive compounds identified to date, including terpenoids, flavonoids, phenolic acids, tannins, alkaloids, sterols, lactones, coumarins, constituents, with flavonoids highlighting wide-ranging pharmacological properties medicinal significance. Despite popularity research, limited systematic comprehensive information been provided on EHH. Therefore, we provide an in-depth overview EHH, covering botanical characteristics, uses, phytochemical composition, properties, additional applications. Furthermore, it addresses current challenges limitations modern research offering critical perspectives guide future studies this field.

Язык: Английский

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Rutaecarpine derivatives synthesized via skeletal reorganization alleviate inflammation-associated oxidative damage by inhibiting the MAPK/NF-κB signaling pathway

RSC Medicinal Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

In recent years, skeleton reorganization based on bioactive natural products has emerged as a novel alternative strategy to the classical approach, mainly focusing peripheral modification of inherent skeleton.

Язык: Английский

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Polyaspers A and B, the First Ergosterol‐Polyether Adducts with Unprecedented 6/6/6/5/5/6/6/6/6 Nonacyclic Architecture from Aspergillus sp. TJ507

Chinese Journal of Chemistry, Год журнала: 2023, Номер 42(7), С. 743 - 751

Опубликована: Дек. 12, 2023

Comprehensive Summary Psoriasis is a chronic immune‐mediated inflammatory skin disease and the TNF‐ α an important therapeutic target of this disease. In our continuous study bioactive natural products from fungi, first ergosterol‐polyether adducts, polyaspers A ( 1 ) B 2 ), along with two known ergosterols, (3 β ,5 ,6 ,22 E )‐5,6‐epoxy‐3‐hydroxyergosta‐8,22‐dien‐7‐one 3 calvasterol 4 were isolated Aspergillus sp. TJ507. Structure elucidation was accomplished by extensive spectroscopic analysis single‐crystal X‐ray diffraction tests. Polyaspers possessing unequalled 6/6/6/5/5/6/6/6/6 nonacyclic system, their biosynthetic pathways proposed to include intermolecular cyclization Diels‐Alder reactions. Activity screen these isolates showed that — could improve cell viability in actinomycin D/TNF‐ induced L929 cells death model, EC 50 values 49.85, 46.75 4.99 μmol/L, respectively, activity even comparable positive control SPD304. Further investigations discovered suppress response simulated HaCaT cells. imiquimod‐induced psoriasis murine significantly restrained development symptoms reduced expression IL‐17 IL‐23, presenting anti‐psoriatic effect. As such, those ergosterol derivatives, might serve as lead compounds for novel inhibitory agents clinical treatment psoriasis.

Язык: Английский

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Jatrophane and ingenane diterpenoids with anti-inflammatory activity from Euphorbia esula

Phytochemistry, Год журнала: 2024, Номер 232, С. 114369 - 114369

Опубликована: Дек. 18, 2024

Язык: Английский

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