Neuroprotective Effect of Nor-Prenylated Acylphloroglucinols from Hypericum perforatum L. (St John’s Wort) in the MPTP-Induced Zebrafish Model DOI Open Access

Wu-Yang Liu,

Peng Zhao, Yihan Liu

и другие.

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(7), С. 3096 - 3096

Опубликована: Март 27, 2025

Hypericum perforatum L. (St John's wort) has been widely studied and used for antidepressant treatment, as well as, rarely, featuring in studies on its chemical composition Parkinson's disease (PD) treatment. Five new nor-prenylated acylphloroglucinols with a cyclohexanone core, norperforatums A-E (1-5), together four known analogs [(2R,3R,4S,6R)-3-methyl-4,6-di(3-methyl-2-butenyl)-2-(2-methyl-1-oxopropyl)-3-(4-methyl-3-pentenyl)cyclohexanone (6), hyperscabrin B (7), (2R,3R,4S,6R)-6-methoxycarbonyl-3-methyl-4,6-di(3-methyl-2-butenyl)-2-(2-methyl-1-oxopropyl)-3-(4-methyl-3-pentenyl)cyclohexanone (8), hyperscabin K (9)], were isolated from the aerial parts of H. perforatum. The structures absolute configurations compounds characterized by multiple spectroscopic means, including nuclear magnetic resonance (NMR), high-resolution electrospray ionization mass spectrometry (HR-ESI-MS), ultraviolet visible absorption spectroscopy (UV), infrared (IR), calculated electronic circular dichroism (ECD) data, X-ray signal crystal diffraction. In addition, efficacy these isolations was evaluated against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced PD zebrafish larvae. Compound 9 had best therapeutic effect, significantly increasing total distance traveled mean speed movement dyskinesia Moreover, it enhanced superoxide dismutase (SOD) activity inhibited reactive oxygen species (ROS) production dose-dependent manner. These results suggest that compound may have ameliorative effects symptoms inhibiting oxidative stress. This study provides insights into treatment PD.

Язык: Английский

Meroterpenoids with bicyclic polyprenylated acylphloroglucinol scaffold and anti-inflammatory activity from Hypericum lancasteri DOI

Jin‐Qiu You,

Yun‐Qi Jin,

Yongwei Miao

и другие.

Phytochemistry, Год журнала: 2025, Номер unknown, С. 114484 - 114484

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
Neuroprotective Effect of Nor-Prenylated Acylphloroglucinols from Hypericum perforatum L. (St John’s Wort) in the MPTP-Induced Zebrafish Model DOI Open Access

Wu-Yang Liu,

Peng Zhao, Yihan Liu

и другие.

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(7), С. 3096 - 3096

Опубликована: Март 27, 2025

Hypericum perforatum L. (St John's wort) has been widely studied and used for antidepressant treatment, as well as, rarely, featuring in studies on its chemical composition Parkinson's disease (PD) treatment. Five new nor-prenylated acylphloroglucinols with a cyclohexanone core, norperforatums A-E (1-5), together four known analogs [(2R,3R,4S,6R)-3-methyl-4,6-di(3-methyl-2-butenyl)-2-(2-methyl-1-oxopropyl)-3-(4-methyl-3-pentenyl)cyclohexanone (6), hyperscabrin B (7), (2R,3R,4S,6R)-6-methoxycarbonyl-3-methyl-4,6-di(3-methyl-2-butenyl)-2-(2-methyl-1-oxopropyl)-3-(4-methyl-3-pentenyl)cyclohexanone (8), hyperscabin K (9)], were isolated from the aerial parts of H. perforatum. The structures absolute configurations compounds characterized by multiple spectroscopic means, including nuclear magnetic resonance (NMR), high-resolution electrospray ionization mass spectrometry (HR-ESI-MS), ultraviolet visible absorption spectroscopy (UV), infrared (IR), calculated electronic circular dichroism (ECD) data, X-ray signal crystal diffraction. In addition, efficacy these isolations was evaluated against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced PD zebrafish larvae. Compound 9 had best therapeutic effect, significantly increasing total distance traveled mean speed movement dyskinesia Moreover, it enhanced superoxide dismutase (SOD) activity inhibited reactive oxygen species (ROS) production dose-dependent manner. These results suggest that compound may have ameliorative effects symptoms inhibiting oxidative stress. This study provides insights into treatment PD.

Язык: Английский

Процитировано

0