PeerJ,
Год журнала:
2023,
Номер
11, С. e15484 - e15484
Опубликована: Июнь 6, 2023
Semiliquidambar
cathayensis
is
widely
used
in
traditional
Chinese
medicine
owing
its
high
concentrations
of
polyphenol,
triterpenoidic
acid,
and
flavonoids.
This
study
aimed
to
explore
the
impact
geographical
origin
tissue
type
on
contents
chemical
compounds
S.
cathayensis,
as
determined
by
colorimetric
chromatographic
methods.
Therefore,
we
quantitively
evaluated
found
tissues
various
organs
plants
collected
six
different
regions.
Overall,
that
affected
content
medicinal
leaves,
with
from
Jingzhou
county
showing
best
therapeutic
potential.
However,
no
specific
correlation
was
observed
latitude.
It
noteworthy
amount
paeoniflorin
other
can
be
biomarkers
type.
Most
accumulated
mainly
whereas
ursolic
oleanolic
acids
roots.
These
results
show
comprehensive
value
leaves
highest,
but
root
should
selected
first
collect
acid
acid.
Applied Sciences,
Год журнала:
2025,
Номер
15(4), С. 2047 - 2047
Опубликована: Фев. 15, 2025
Hypericum
perforatum
L.,
commonly
known
as
St.
John’s
wort,
is
a
widely
distributed
herbaceous
plant
utilized
in
traditional
and
phytomedicinal
applications,
particularly
for
its
hydrophilic
bioactive
compounds.
It
often
used
treating
early
depressive
states.
In
this
study,
we
focused
on
reporting
the
tocotrienols—lipophilic
phytochemicals
with
health-promoting
properties—in
wort.
H.
flowerheads
predominantly
contained
tocotrienols
compared
tocopherols
(54
30
mg/100
g
dry
weight,
respectively).
The
major
(T3)
were
δ-T3
α-T3
(34.0
17.6
Tocopherols
are
lipophilic
that
cannot
be
present
wort
water
extracts
(tea
infusions),
but
they
can
recovered
from
remaining
residues
of
tea
infusions
by
using
hydroethanolic
solutions.
A
50.0%
(v/v)
solution
was
not
effective
recovery
tocochromanols.
greatest
increase
extractability
tocochromanols
observed
70.0–80.0%
extracts,
while
increasing
ethanol
concentration
90.0%
to
96.2%
only
slightly
improved
(not
statistically
significant).
For
each
concentration,
proportionally
higher
than
tocopherols.
Residues
proposed
valuable
by-products
rich
tocotrienols.
Horticulturae,
Год журнала:
2025,
Номер
11(2), С. 205 - 205
Опубликована: Фев. 15, 2025
St.
John’s
wort
(Hypericum
perforatum
L.)
is
an
ornamental
and
medical
plant,
distributed
worldwide,
which
rich
in
diverse
secondary
metabolites.
The
discovery
of
the
presence
tocotrienols
(rare
prenyllipids)
H.
marks
a
new
chapter
demanding
deeper
understanding
accumulation
these
lipophilic
biomolecules.
Three
wild
populations
were
harvested
Latvia
at
three
different
locations
from
2022
to
2024
separated
into
stems,
leaves,
flower
buds,
flowers.
Plant
samples
freeze-dried,
ground,
saponified,
analyzed
for
tocochromanol
profiles
using
RP-LC-FLD
confirmed
by
LC-MS
system.
Eight
tocochromanols,
four
tocopherols
(Ts),
(T3s),
identified
perforatum.
Leaves
dominated
α-T
(82%),
buds
flowers
δ-T3
(44%);
thus,
lowest
concentrations
recorded
leaves
highest
buds.
other
present
as
follows:
α-T3
>
γ-T3
β-T3.
location
perforatum,
year
harvest,
aerial
part
their
interactions
all
significantly
influenced
content
tocochromanols
(p
<
0.05).
study
demonstrates
relevant
discoveries
regarding
various
organs
variability.
Molecules,
Год журнала:
2025,
Номер
30(4), С. 901 - 901
Опубликована: Фев. 15, 2025
St.
John's
wort
(Hypericum
perforatum)
is
a
medicinal
plant
known
for
its
bioactive
compounds,
including
tocopherols
and
tocotrienols,
which
possess
antioxidant
anti-inflammatory
properties.
These
compounds
play
vital
roles
in
the
plant's
metabolism
have
potential
applications
cosmetic
pharmaceutical
industries.
However,
content
of
these
different
anatomical
parts
plant,
as
well
influence
environmental
factors,
such
year
collection,
remain
underexplored.
This
study
examined
tocochromanols
H.
perforatum
leaves,
flowers,
flower
buds,
collected
Poland
during
years
2022-2024.
The
results
revealed
that
predominantly
accumulated
while
tocotrienols
were
more
abundant
flowers
buds.
collection
had
significant
effect
on
tocopherol
levels,
tocotrienol
showed
lower
sensitivity
to
fluctuations,
indicating
their
higher
stability.
can
be
considered
valuable
source
biologically
active
especially
exhibit
stability
less
susceptibility
variability.
underline
importance
considering
both
when
aiming
maximize
production
compounds.
Horticulturae,
Год журнала:
2024,
Номер
10(1), С. 59 - 59
Опубликована: Янв. 6, 2024
Fifteen
transgenic
shoot
clones
(TS
A-TS
O)
regenerated
from
Hypericum
perforatum
hairy
roots
were
evaluated
for
growth
characteristics,
phenylpropanoid,
and
naphthodianthrone
production,
as
well
non-enzymatic
enzymatic
antioxidant
status.
Transgenic
shoots
displayed
higher
biomass
production
non-altered
phenotypes
compared
to
control
shoots.
Phenylpropanoid
in
TS
was
not
related
phenylalanine
ammonia
lyase
activity
indicating
that
alternative
enzymes
could
be
involved
the
regulation
of
phenylpropanoid/flavonoid
biosynthesis.
The
positive
correlation
between
phenylpropanoids
(phenolic
acids,
flavonoids,
flavan-3-ols,
tannins)
assays
suggested
these
compounds
are
main
contributors
redox
state
radical
scavenging
properties
clones.
More
importantly,
enhanced
(hypericin,
pseudohypericin
protopseudohypericin)
associated
with
number
leaf
dark
glands.
Concerning
status
TS,
guaiacol
peroxidase
shown
enzyme
turns
down
H2O2
levels,
while
upregulation
superoxide
dismutase
coincided
decreased
O2•−
production.
efficiency
neutralization
level
MDA
consequently
delayed
lipid
peroxidation
Altogether,
H.
proposed
a
prospective
biotechnological
system
scale-up
naphthodianthrones
properties.
Separations,
Год журнала:
2022,
Номер
9(1), С. 17 - 17
Опубликована: Янв. 14, 2022
The
Hypericum
genus
contains
one
of
the
few
genera
flowering
plants
that
a
species
with
authorization
for
marketing
as
traditional
medicine,
H.
perforatum.
Due
to
fact
this
is
large
genus,
comprising
numerous
species,
amount
interest
has
been
shown
over
years
in
study
its
various
pharmacological
activities.
chemical
composition
these
quite
similar,
containing
compounds
belonging
class
phloroglucinol
derivatives,
naphthodianthrones,
phenols,
flavonoids
and
essential
oils.
Taking
all
into
consideration,
present
aims
offer
an
overview
from
point
view
their
extraction
techniques
analysis
methods.
An
extensive
on
scientific
literature
was
performed,
it
revealed
wide
range
solvents
methods,
among
which
ethanol
methanol,
together
maceration
ultrasonication,
are
most
frequent.
Regarding
separation
spectral
employed.
Therefore,
provides
necessary
data
future
studies
offering
complete
possible
basis
development.
Plants,
Год журнала:
2023,
Номер
12(4), С. 923 - 923
Опубликована: Фев. 17, 2023
Hypericum
species
and
especially
H.
perforatum
L.
are
well
known
for
their
therapeutic
applications.
The
present
study
assessed
the
essential
oil
(EO)
composition,
antifungal
aphid
suppression
activity
of
seven
Bulgarian
species.
EOs
were
analyzed
by
GC-MS-FID.
Two
experiments
conducted.
In
first
experiment,
perforatum,
maculatum,
hirsutum
used.
Additionally,
EO
composition
extracted
via
hydrodistillation
(ClevA)
commercial
steam
distillation
(Com)
compared.
second
experiment
compared
cerastoides,
rumeliacum,
montbretii,
calycinum
(flowers
leaves)
collected
with
n-hexane.
Overall,
constituents
belonged
to
four
classes,
namely
alkanes,
monoterpenes,
sesquiterpenes,
fatty
acids.
main
class
compounds
in
maculatum
(section
Hypericum)
sesquiterpenes
both
except
(Com).
montbretii
Drosocarpium)
had
monoterpenes
(38.09%)
(37.09%)
as
major
groups,
while
Taeniocarpium)
contained
predominately
alkanes
(67.19%).
cedrol
(5.04%),
found
time
Fatty
acids
cerastoides
Campylopus),
most
abundant
rumeliacum
EOs.
α-Pinene
germacrene
D
all
cerastoides.
significant
repellent
insecticidal
against
two
species,
Rhopalosiphum
padi
(Bird
Cherry-oat
aphid)
Sitobion
avenae
(English
grain
at
concentrations
0%,
1%,
2.5%,
3.5%,
4.5%,
5%.
tested
did
not
show
selected
economically
important
agricultural
fungal
pathogens
Fusarium
spp.,
Botrytis
cinerea,
Colletotrichum
Rhizoctonia
solani,
Aspergillus
sp.
flora
could
be
utilized
development
new
biopesticides
control.
Anti-Cancer Agents in Medicinal Chemistry,
Год журнала:
2024,
Номер
24(6), С. 464 - 476
Опубликована: Фев. 2, 2024
Hyperoside
is
a
flavonol
glycoside
isolated
from
Hypericum
perforatum
L.
that
has
inhibitory
effects
on
cancer
cells;
however,
its
prostate
(PCa)
remain
unclear.
Therefore,
we
studied
the
anti-PCa
of
hyperoside
and
underlying
mechanisms
in
vitro
vivo.
This
study
aimed
to
explore
mechanism
anti-PCa.
3-(4,5-Dimethyl-2-Thiazolyl)-2,5-Diphenyl
Tetrazolium
Bromide
(MTT),
transwell,
flow
cytometry
assays
were
used
detect
PCa
cell
growth,
invasion,
apoptosis.
Immunoblot
analysis,
immunofluorescence,
immunoprecipitation,
quantitative
real-time
PCR
(qRT-PCR)
analyze
antitumor
hyperoside.
inhibited
cycle
induced
Furthermore,
RING
finger
protein
8
(RNF8),
an
E3
ligase
assembles
K63
polyubiquitination
chains,
was
predicted
be
direct
target
downregulated
by
Downregulation
RNF8
impeded
nuclear
translocation
β-catenin
disrupted
Wnt/β-catenin
pathway,
which
reduced
expression
genes
c-myc,
cyclin
D1,
programmed
death
ligand
1
(PD-L1).
Decreased
PD-L1
levels
contributed
immunity
Jurkat
cells
vitro.
Finally,
vivo
studies
demonstrated
significantly
tumor
size,
expression,
apoptosis
tissues
subcutaneous
mouse
model.
exerts
effect
reducing
protein,
inhibiting
β-catenin,
disrupting
turn
improving
immunity.
Journal of Applied Polymer Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 6, 2025
ABSTRACT
This
study
aimed
to
fabricate
and
evaluate
TPU/polylactic
acid
foams
loaded
with
natural
extracts
of
Curcuma
longa
L.
(C)
Hypericum
perforatum
(H)
for
WD
application.
In
the
frame
structure/properties
relationships
study,
different
complementary
analyzes
materials,
such
as
water
contact
angles
measurements,
vapor
transmission
rate,
absorption,
release
studies
were
performed,
in
connection
structural
thermal
characterizations
performed
using
scanning
electron
microscopy,
differential
calorimetry
Fourier
transform
spectroscopy.
The
absorption
capacity
blank
blend
foam
(C
H)
was
found
be
range
8.31%
±
0.27,
90.7%
4.1
164%
4.0%,
respectively.
presented
cumulative
45.5%
2%
100%
1.1%
within
96
h
acceptable
rate
2088
66
3520
991
g·m
−2
·24
−1
,
Summary,
investigated
foams,
enriched
both
extracts,
showed
excellent
performances
agreement
materials
requirements,
higher
cell
viability
proliferation
compared
reference
well
non‐cytotoxic
effects
on
human
fibroblasts
experimental
conditions.
