Discover Chemistry.,
Год журнала:
2025,
Номер
2(1)
Опубликована: Март 26, 2025
In
recent
years,
microbial
infections
have
become
the
most
common
and
leading
cause
of
death
worldwide.
From
them,
Gram-positive
bacterial
strain
Staphylococcus
aureus
is
a
highly
effective
pathogen
that
can
infect
almost
every
human
body
tissue,
from
minor
skin
diseases
to
life-threatening
infections.
Antibiotics
are
generally
used
treat
infections,
but
due
their
excessive
careless
usage,
microorganisms
gradually
developed
resistance
them.
Therefore,
it
necessary
develop
novel
drugs
minimize
drug
resistance.
Many
available
in
market
they
not
as
before.
Currently,
coumarin
derivatives
regarded
medicinal
chemistry
favored
by
new
researchers
diverse
pharmaceutical
properties,
including
antibacterial,
anticancer,
antitubercular,
antioxidant,
etc.
It
also
possesses
antibiotic
qualities
well.
Coumarines
commercially
long
been
utilized
clinical
treatment.
These
therapeutic
properties
help
antimicrobial
agents
Hence,
this
review
article
provides
significant
attention
developments
structure–activity
relationships
(SAR)
C-3
substituted
combat
infection
caused
S.
aureus.
Journal of Taibah University for Science,
Год журнала:
2024,
Номер
19(1)
Опубликована: Дек. 19, 2024
Coumarin
derivatives
(CDs)
possess
diverse
pharmacological
properties,
but
their
antidiabetic
potential
is
not
fully
explored.
In
this
perspective,
we
selected
108
plant-derived
CDs
and
investigated
potency,
taking
a
panel
of
putative
targets:
AKT1,
ACACB,
CDK4,
α-amylase,
GLUT1,
PTP1B
in
computer-aided
drug
design
(CADD)
platform.
addition,
predicted
toxicity,
pharmacokinetics,
bioavailability,
ability
profiles
CDs.
Further,
molecular
dynamics
(MD)
simulations
were
employed
to
observe
the
dynamic
behaviour
two
(sanandajin
or
SANA,
sinkianone
SINK)
standards
(glimepiride
G
resveratrol
RESV)
with
AKT1
at
100
nanoseconds.
Overall,
findings
reveal
that
SANA
SINK
exhibited
stronger
binding
affinities
than
lesser
toxicity
favorable
drug-ability
use
as
bioactive
therapeutic
agents
for
management
diabetics.
The
systematic
CADD
analyses
are
able
locate
encourage
further
experimental
studies
mainstream
applications.
