bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 2, 2024
Many
pregnant
women
use
cannabidiol
(CBD)
as
a
natural
remedy
to
alleviate
symptoms
such
nausea,
insomnia,
anxiety,
and
chronic
pain.
As
much
20%
of
pregnancies
in
the
USA
Canada
may
involve
CBD-only
products.
CBD
crosses
placenta
affect
fetal
development,
potentially
leading
neuropsychiatric
conditions
later
life.
Given
limited
understanding
effects
during
pregnancy,
we
adopted
longitudinal
approach
investigate
neurodevelopmental
trajectory
associated
with
prenatal
exposure.
Pregnant
mice
were
administered
3
mg/kg
from
gestational
days
5
18.
At
early
adolescence,
offspring
displayed
sex-specific
behavioral
changes.
Females,
but
not
males,
exhibited
complex
anxiety-like
phenotype
elevated
plus
maze
task.
This
persisted
into
adulthood
open
field
test
was
accompanied
by
altered
reward
responsiveness.
Throughout
post-natal
life,
female
demonstrated
heightened
stretch-attend
postures,
risk-assessment
behavior
reflecting
approach-avoidance
tendencies
anxiety.
Finally,
exposure
increased
repetitive
behaviors
adult
animals
both
sexes,
evidenced
marble
burying
These
results
provide
strong
evidence
disruptions
developmental
trajectories
anxiety
They
challenge
perception
that
is
universally
safe
highlight
vulnerabilities
linked
JAMA Internal Medicine,
Год журнала:
2024,
Номер
184(9), С. 1083 - 1083
Опубликована: Июль 22, 2024
Many
studies
have
evaluated
whether
in
utero
cannabis
exposure
is
associated
with
fetal
and
neonatal
outcomes,
yet
little
known
about
prenatal
use
maternal
health
outcomes
during
pregnancy.
Cannabis and Cannabinoid Research,
Год журнала:
2024,
Номер
9(3), С. 781 - 796
Опубликована: Фев. 15, 2024
Studies
indicate
that
∼7%
of
pregnant
individuals
in
North
America
consume
cannabis
pregnancy.
Pre-clinical
studies
have
established
maternal
exposure
to
Δ
Cannabis and Cannabinoid Research,
Год журнала:
2024,
Номер
9(3), С. 766 - 780
Опубликована: Фев. 16, 2024
Introduction:
Cannabis
use
is
increasing
among
pregnant
people,
and
cannabidiol
(CBD),
a
constituent
of
cannabis,
often
perceived
as
"natural"
"safe"
it
non-intoxicating.
In
utero,
cannabis
exposure
associated
with
negative
health
outcomes,
including
fetal
growth
restriction
(FGR).
The
placenta
supplies
oxygen
nutrients
to
the
fetus,
alterations
in
placental
development
can
lead
FGR.
While
there
has
been
some
investigation
into
effects
Δ9-THC,
limited
impacts
utero
gestational
CBD
on
placenta.
Frontiers in Public Health,
Год журнала:
2024,
Номер
12
Опубликована: Фев. 20, 2024
Background
Marijuana
potency
and
utilization
both
continue
to
increase
across
the
United
States.
While
overall
prevalence
of
cannabinoid
during
pregnancy
has
been
surveyed
in
various
studies,
direct
impact
changing
governmental
policies
on
use
is
less
characterized.
Thus,
we
aimed
investigate
how
legalization
recreational
products
impacted
state
New
Mexico.
Methods
Participants
who
had
a
live
birth
two
study
epochs
were
included:
pre-legalization
(Epoch
1:
1
January
2019–31
March
2021)
post-legalization
2:
November
2021–30
2022).
further
divided
into
case
group
[prenatal
exposure
(PCE)]
vs.
control
(no
PCE),
with
cases
being
identified
by
documented
self-report
or
positive
laboratory
toxicology
test
for
pregnancy.
Results
A
total
1,191
maternal/infant
dyads
included
Epoch
1,
378
2.
In
788
controls
403
cases,
while
2
292
86
cases.
Interestingly
there
was
significant
decrease
tests
compared
1.
Infants
born
following
PCE
groups
more
commonly
via
Cesarean
section,
significantly
smaller
weight,
length,
head
circumference
as
well
lower
Apgar
scores
at
5
min.
Conclusion
The
finding
decreased
reported
contradictory
previous
studies
which
have
shown
increased
rates
after
legalization.
This
could
be
due
multiple
factors
including
changes
screening
practices,
COVID-19
pandemic,
lack
commercialization
THC
products.
Additional
are
needed
characterize
impacts
Journal of Interpersonal Violence,
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 14, 2024
Many
health
organizations
recommend
that
mothers
avoid
cannabis
during
pregnancy
and
breastfeeding
because
they
are
concerned
about
exposing
infants
to
Δ-9-tetrahydrocannabinol
(THC),
the
psychoactive
substance
in
cannabis.
Yet,
data
collected
by
U.S.
Centers
for
Disease
Control
demonstrate
a
small
percentage
of
continue
use
despite
warnings.
The
frequency
is
an
important
variable
frequent
increases
THC
exposure.
present
study
examined
two
variables
related
breastfeeding:
problems
adverse
childhood
experiences
(ACEs).
We
possible
mediation
effect
on
relationship
between
ACEs
breastfeeding.
Our
sample
was
entirely
comprised
1,343
women
who
used
online.
were
recruited
from
Facebook
group
supports
pregnant
To
be
included,
participants
needed
at
least
18
years
old
have
while
or
79%
White,
8%
Hispanic,
14%
Black,
1,199
currently
resided
United
States,
76
Canada,
11
Kingdom,
rest
13
other
countries.
Ninety-three
percent
reported
one
ACE,
59%
4
more.
Ninety-six
using
treat
problem,
number
ranged
0
8.
Two
analyses
found
total
increased
risk
problems,
which
use.
ACE
not
significantly
once
accounted
for.
women,
but
indirectly
through
trauma’s
impact
problems.
These
findings
suggest
practitioners
might
able
lower
if
directly
address
Cells,
Год журнала:
2024,
Номер
13(17), С. 1486 - 1486
Опубликована: Сен. 4, 2024
Many
expectant
mothers
use
CBD
to
alleviate
symptoms
like
nausea,
insomnia,
anxiety,
and
pain,
despite
limited
research
on
its
long-term
effects.
However,
passes
through
the
placenta,
affecting
fetal
development
impacting
offspring
behavior.
We
investigated
how
prenatal
exposure
affects
insular
cortex
(IC),
a
brain
region
involved
in
emotional
processing
linked
psychiatric
disorders.
The
IC
is
divided
into
two
territories:
anterior
(aIC),
socioemotional
signals,
posterior
(pIC),
specializing
interoception
pain
perception.
Pyramidal
neurons
aIC
pIC
exhibit
sex-specific
electrophysiological
properties,
including
variations
excitability
excitatory/inhibitory
balance.
IC's
cellular
properties
synaptic
strength
of
both
sexes
from
mice
exposed
low-dose
during
gestation
(E5-E18;
3
mg/kg,
s.c.).
Prenatal
induced
territory-specific
changes
active
passive
membrane
as
well
intrinsic
balance,
adult
offspring.
data
indicate
that
utero
disrupts
neuronal
development,
leading
loss
functional
distinction
between
territories.
These
findings
may
have
significant
implications
for
understanding
effects
behaviors
Frontiers in Pediatrics,
Год журнала:
2023,
Номер
11
Опубликована: Окт. 11, 2023
Cannabinoid
use
in
all
populations
is
increasing
as
legalization
across
the
United
States
continues.
Concerningly,
there
a
lack
of
caution
provided
by
medical
providers
to
pregnant
individuals
impact
cannabinoids
could
have
on
developing
fetus.
Research
continues
both
preclinical
and
clinical
areas,
severely
needed,
potency
delta-9-tetrahydrocannabinol
(THC),
primary
psychoactive
component
cannabis,
has
increased
dramatically
since
initial
studies
were
completed.
Thus
far,
raise
compelling
evidence
for
short
term
memory
deficits,
impulse
control
issues,
attention
deficiencies
following
prenatal
cannabinoid
exposure
(PCE).
These
changes
may
be
mediated
through
epigenetic
modifications
that
not
only
current
offspring
but
carry
forward
future
generations.
While
additional
are
pregnancy
pause
from
products
should
strongly
recommended
ensure
optimal
health
well-being
our
Epilepsia,
Год журнала:
2023,
Номер
64(12), С. 3354 - 3364
Опубликована: Окт. 1, 2023
In
the
absence
of
safety
data
in
humans,
use
cannabidiol
(CBD)
is
not
recommended
during
pregnancy.
Yet
>50%
pregnancies
women
with
epilepsy
are
unintended,
making
fetal
exposure
to
CBD
possible.
As
a
small-molecule,
highly
lipid-soluble
drug,
likely
be
distributed
into
placenta
and
cross
it.
To
estimate
placental
distribution
profile
its
potential
short-term
effects,
we
conducted
an
ex
vivo
perfusion
study
human
placentas.Placentas
were
obtained
from
healthy
undergoing
cesarean
deliveries.
Selected
cotyledons
cannulated
perfused
for
180
min
CBD-containing
medium
(250
ng/mL,
.796
μmol·L-1
;
representative
low
therapeutic
concentration;
n
=
8).
concentrations
determined
at
tissue
using
liquid
chromatography-tandem
mass
spectrometry.
A
customized
gene
panel
array
was
used
analyze
expression
selected
genes
as
well
placentas
1000
ng/mL
(3.18
high
8)
those
exposed
vehicle.CBD
sequestered
tissue,
exhibiting
significant
variability
across
samples
(median
5342
ng/g
range
1066-9351
tissue).
compartment
one
fifth
measured
maternal
59
48-72
vs.
280
159-388
respectively;
p
<
.01).
Placental
significantly
altered
by
CBD.The
acts
depot
CBD,
slowing
down
fetus.
This
phenomenon
might
yield
flatter
but
prolonged
levels
vivo.
The
attenuated
transplacental
transfer
does
imply
that
pregnant
safe
Only
pregnancy
registries
neurocognitive
assessments
would
establish
risk
being
antenatally
CBD.
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Июнь 29, 2024
Many
expectant
mothers
use
CBD
to
alleviate
symptoms
like
nausea,
insomnia,
anxiety,
and
pain,
despite
limited
research
on
its
long-term
effects.
However,
passes
through
the
placenta,
affecting
fetal
development
impacting
offspring
behavior.
We
investigated
how
prenatal
exposure
affects
insular
cortex
(IC),
a
brain
region
involved
in
emotional
processing
linked
psychiatric
disorders.
The
IC
is
divided
into
two
territories:
anterior
(aIC),
socioemotional
signals,
posterior
(pIC),
specializing
interoception
pain
perception.
Pyramidal
neurons
aIC
pIC
exhibit
sex-specific
electrophysiological
properties,
including
variations
excitability
excitatory/inhibitory
balance.
IC's
cellular
properties
synaptic
strength
of
both
sexes
from
mice
exposed
low-dose
during
gestation
(E5-E18;
3mg/kg,
s.c.).
Prenatal
induced
territory-specific
changes
active
passive
membrane
as
well
intrinsic
balance,
adult
offspring.
data
indicate
that
in-utero
disrupts
neuronal
development,
leading
loss
functional
distinction
between
territories.
These
findings
may
have
significant
implications
for
understanding
effects
behaviors
