International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(7), С. 2859 - 2859

Опубликована: Март 21, 2025

Trophoblast fusion into the multinucleated syncytiotrophoblast (SCT) appears as an inescapable feature of placentation in mammals and other viviparous species. The trophoblast cells underlying syncytium are considered a reservoir for restoration aging peripheric structure. transition from trophoblasts to SCTs has be tightly regulated, could altered by genetic anomalies or environmental exposure. resulting defective placental function one causes major diseases, such preeclampsia (PE) Intra-Uterine Growth Restriction (IUGR). This review attempts take stock current knowledge about mechanisms their deregulations.

Язык: Английский