Differences in Toxicity Produced by the Various Polymer Types of Nanoplastics on Hepg2 Cells DOI

Lihua Ma,

Zijie Wu,

Zifan Lu

и другие.

Опубликована: Янв. 1, 2023

The problem of microplastics (MPs) contamination in food has gradually come to the fore. MPs can be transmitted through chain and accumulate within various organisms, ultimately posing a threat human health. For first time, we compared differences toxicity polyethylene terephthalate (PET), polyvinyl chloride (PVC), polystyrene (PS) nanoplastics (NPs) different polymer types HepG2 cells their potential toxic mechanisms. Common polymers PET, PVC, PS NPs, which had similar particle size, surface charge, shape, were prepared using nanoprecipitation emulsion polymerization successfully. This enabled us investigate impact on cytotoxicity. findings demonstrated that high concentrations PET PVC NPs trigger cell apoptosis oxidative stress, but did not have same harmful impact. Furthermore, our analysis transcriptomics data revealed significantly reduced expression genes related bile acid metabolism PPAR signaling pathway. effect may lead perturbation cellular lipid metabolism. resulted higher degree down-regulation these NPs. It is worth noting inhibit cycle DNA repair-related p53 pathway, aggravating damage arresting progression by inhibiting repair. constitute principal factor accounting for variations across types. These comparative studies discoveries regarding molecular mechanisms provide theoretical basis mitigating health risks stemming from

Язык: Английский

Effects of polystyrene microplastics on the growth and metabolism of highland barley seedlings based on LC-MS DOI Creative Commons

Wenqi Xiao,

Peng Xiang, Wenlong Liao

и другие.

Frontiers in Plant Science, Год журнала: 2024, Номер 15

Опубликована: Дек. 17, 2024

Microplastics are widely present in the environment and can adversely affect plants. In this paper, effects of different concentrations microplastics on physiological indices metabolites highland barley were investigated for first time using a metabolomics approach, revealed response mechanism seedlings to polystyrene (PS-MPs) was revealed. The results showed that aboveground biomass exposed low (10 mg/L) medium (50 PS-MPs increased by 32.2% 48.2%, respectively. root length also 16.4% 21.6%, However, high (100 decreased 34.8%, leaf 20.7%, 25.9%. Microplastic exposure levels antioxidant activity, suggesting responds microplastic stress through oxidative stress. Metabolome analysis contents 4 significantly with increasing concentration positive ionmode, while 8 negative ionmode (

Язык: Английский

Процитировано

0
Plant responses to emerging contaminants DOI
Fayuan Wang, Weitao Liu

Plant Physiology and Biochemistry, Год журнала: 2023, Номер 201, С. 107873 - 107873

Опубликована: Июнь 29, 2023

Язык: Английский

Процитировано

1
Differences in Toxicity Produced by the Various Polymer Types of Nanoplastics on Hepg2 Cells DOI

Lihua Ma,

Zijie Wu,

Zifan Lu

и другие.

Опубликована: Янв. 1, 2023

The problem of microplastics (MPs) contamination in food has gradually come to the fore. MPs can be transmitted through chain and accumulate within various organisms, ultimately posing a threat human health. For first time, we compared differences toxicity polyethylene terephthalate (PET), polyvinyl chloride (PVC), polystyrene (PS) nanoplastics (NPs) different polymer types HepG2 cells their potential toxic mechanisms. Common polymers PET, PVC, PS NPs, which had similar particle size, surface charge, shape, were prepared using nanoprecipitation emulsion polymerization successfully. This enabled us investigate impact on cytotoxicity. findings demonstrated that high concentrations PET PVC NPs trigger cell apoptosis oxidative stress, but did not have same harmful impact. Furthermore, our analysis transcriptomics data revealed significantly reduced expression genes related bile acid metabolism PPAR signaling pathway. effect may lead perturbation cellular lipid metabolism. resulted higher degree down-regulation these NPs. It is worth noting inhibit cycle DNA repair-related p53 pathway, aggravating damage arresting progression by inhibiting repair. constitute principal factor accounting for variations across types. These comparative studies discoveries regarding molecular mechanisms provide theoretical basis mitigating health risks stemming from

Язык: Английский

Процитировано

0