Plants,
Год журнала:
2025,
Номер
14(2), С. 206 - 206
Опубликована: Янв. 13, 2025
Medicinal
plants
are
sources
of
crude
traditional
herbal
medicines
that
utilized
to
reduce
the
risk
of,
treat,
or
manage
diseases
in
most
indigenous
communities.
This
is
due
their
potent
antioxidant
and
anti-inflammatory
effects.
It
estimated
about
80%
population
developing
countries
rely
on
for
healthcare.
signifies
need
medicines,
which
polyherbal
formulations
prepared
by
health
practitioners.
review
examines
preparatory
steps
extract
bioactive
phytoconstituents
post-extraction
processes
increase
potency
extracted
phytoconstituents.
Achieving
this
will
allow
reduced
use
plant
materials
promote
sustainable
limited
resource
medicinal
plants,
especially
our
South
African
context.
Electronic
ethnobotanical
books
online
databases
were
used
find
studies
focus
phytoconstituent
extraction
processing
enhance
Modification
synthesize
daughter
compounds
facilitates
an
enhancement
bioavailability.
Based
data
collected
through
review,
importance
understanding
properties
targeted
essential
selecting
required
method.
determines
quality
yield
Frontiers in Plant Science,
Год журнала:
2025,
Номер
15
Опубликована: Янв. 10, 2025
This
study
aims
to
investigate
the
impact
of
geographical
origin
on
metabolite
composition
and
bioactivity
Thesium
chinense
Turcz.
(TCT),
a
member
Apiaceae
family
renowned
for
its
wide
range
pharmacological
properties,
including
antioxidant,
antimicrobial,
anti-inflammatory
effects.
In
this
study,
we
investigated
whole
plants
TCT
from
different
regions
in
China,
aiming
explore
variation
TCT.
A
non-targeted
metabolomics
approach
was
employed
using
ultra-high-performance
liquid
chromatography
combined
with
quadrupole
time-of-flight
mass
spectrometry
(UPLC-Q-TOF-MS).
Principal
component
analysis
(PCA)
partial
least
squares
discriminant
(PLS-DA)
were
utilized
identify
differentiate
profiles.
We
bioactivity,
antioxidant
activity,
total
flavonoid
content
(TFC),
characteristic
compounds
sourced
regions.
further
metabolic
differences
quality
characteristics
various
origins.
PCA
PLS-DA
analyses
indicated
that
samples
origins
could
be
clearly
distinguished.
The
revealed
54
differential
metabolites,
predominantly
flavonoids
alkaloids.
KEGG
pathway
significant
variations
biosynthesis
pathways
flavanols
among
samples.
Anhui
province
exhibited
highest
TFC
strongest
activities,
while
Jilin
showed
lowest.
strong
correlation
observed
between
origins,
suggesting
is
significantly
influenced
by
provenance.
Additionally,
activities
validated,
showing
predictive
relationship
TFC.
research
highlights
potential
discerning
subtleties
plant
metabolomes,
contributing
advancement
traditional
Chinese
medicine
integration
into
modern
healthcare
practices.
Physiologia Plantarum,
Год журнала:
2025,
Номер
177(1)
Опубликована: Янв. 1, 2025
Heavy
metal
pollution,
especially
arsenic
toxicity,
significantly
impairs
plant
growth
and
development.
Phenolic
acids,
known
for
their
antioxidant
properties
involvement
in
stress
signaling,
are
gaining
increased
attention
as
secondary
metabolites
with
the
potential
to
enhance
resistance
these
stressors.
This
study
aimed
investigate
effects
of
different
concentrations
syringic
acid
(SA1,
10
μM;
SA2,
250
SA3,
500
μM)
on
growth,
photosynthetic
parameters,
activity
lettuce
seedlings
subjected
(As,
100
μM).
Arsenic
reduced
by
56.7%,
water
content
7.39%,
osmotic
26.2%
leaves
compared
control.
Conversely,
SA1
SA2
treatments
mitigated
adverse
preserved
balance
plants.
However,
SA3
treatment
led
a
decrease
18.9%
39.5%
As+SA3
groups,
respectively,
indicating
that
high-dose
SA
adversely
affected
under
both
control
conditions.
Exogenous
improved
photosynthesis,
whereas
provided
milder
benefits
did
not
reduce
exposure.
H2O2
47.3%
lipid
peroxidation
33.4%
seedlings.
effectively
oxidative
enhancing
activities
key
enzymes,
such
superoxide
dismutase
(SOD)
peroxidase
(POX).
Moreover,
was
successful
maintaining
glutathione
(GSH)
pool,
primarily
promoted
ascorbate
(AsA)
regeneration.
In
conclusion,
μM
(SA1)
identified
optimal
dose
reducing
supporting
growth.
Overall,
findings
underscore
resilience
heavy
toxicity.
Abstract
Green
tea
catechins
are
bioactive
polyphenolic
compounds
that
possess
a
number
of
biological
activities
and
potential
health
benefits.
This
review
will
focus
on
discussing
the
effects
green
catechins,
with
particular
emphasis
clinical
studies
evaluate
their
anticancer
potential.
Epigallocatechin
gallate
(EGCG),
either
as
stand-alone
treatment
or
in
conjunction
conventional
therapies,
represents
promising
alternative
strategy
for
management
leukaemia.
was
based
search
scientific
sources
indexed
databases
PubMed
Scopus
using
following
keywords:
‘Camellia
sinensis’,
‘tea
catechins’,
‘anticancer’,
‘antioxidant’,
‘hematological
cancer’,
‘leukaemia’
combination.
A
deeper
comprehension
multifaceted
mechanisms
findings
research
could
facilitate
development
novel
strategies
integration
into
practice,
thus
enhancing
outcomes
patients
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(5), С. 2122 - 2122
Опубликована: Фев. 27, 2025
To
investigate
the
anti-bacterial
and
anti-inflammatory
properties
of
sophoridine
elucidate
its
mechanism
action,
we
carried
out
both
in
vitro
vivo
experiments.
Multiple
bacterial
strains
were
utilized
to
determine
effective
concentration
antibacterial
bactericidal
assays.
Subsequently,
LPS-stimulated
RAW264.7
cells
E.
coli-challenged
BALB/c
mice
models
employed
evaluate
production
inflammatory
cytokines.
Our
results
showed
that
concentrations
exceeding
5.12
mg/mL
significantly
inhibited
cell
viability,
while
0.32
demonstrated
optimal
activity
at
12
h.
In
coli-induced
diarrheal
mice,
doses
15,
30,
60
mg/kg
BW
alleviated
fecal
occult
blood
exhibited
effects
by
reducing
level
serum
TNF-α,
IL-1β,
IL-6
levels,
increasing
IL-10,
inhibiting
leucocyte
infiltration
duodenum.
Notably,
15
effectively
decreased
mRNA
protein
expression
NF-κB
p65.
These
findings
suggest
has
promising
potential
for
treatment
diarrhea
through
mediated
inhibition
activation.
