Mendelian randomization study on the causal effects of omega-3 fatty acids on rheumatoid arthritis

Clinical Rheumatology, Год журнала: 2022, Номер 41(5), С. 1305 - 1312

Опубликована: Янв. 8, 2022

Язык: Английский

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The Controversial Roles of Areca Nut: Medicine or Toxin?

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(10), С. 8996 - 8996

Опубликована: Май 19, 2023

Areca nut (AN) is used for traditional herbal medicine and social activities in several countries. It was as early about A.D. 25-220 a remedy. Traditionally, AN applied medicinal functions. However, it also reported to have toxicological effects. In this review article, we updated recent trends of research addition acquire new knowledge AN. First, the history usage from ancient years described. Then, chemical components their biological functions compared; arecoline an especially important compound extract has different effects caused by components. Thus, dual with pharmacological were summarized. Finally, described perspectives, challenges will provide insight removing or modifying toxic compounds extractions enhancing activity treat diseases future applications.

Язык: Английский

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Gut symbiont-derived anandamide promotes reward learning in honeybees by activating the endocannabinoid pathway

Cell Host & Microbe, Год журнала: 2024, Номер unknown

Опубликована: Окт. 1, 2024

Язык: Английский

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Organ-Specific Responses to Chronic High-Fat Diets in Mice: Insights into Phospholipid Fatty Acid Distribution

Nutrients, Год журнала: 2025, Номер 17(5), С. 821 - 821

Опубликована: Фев. 27, 2025

Background/Objectives: This research aimed to investigate phospholipid fatty acid (PLFA) distribution in the brain, kidneys, and white adipose tissue (WAT) lipid profiles response high-fat diets. Methods: Adult female C57BL/6 mice were fed diets containing 25% linseed, palm, or sunflower oil for 100 days. The composition of dietary oils PL analyzed using gas-liquid chromatography. Results: Linseed increased n-3 polyunsaturated acids (PUFAs) with subsequent conversion into long-chain PUFAs brain kidney PL, while only alpha-linolenic was elevated WAT. Palm resulted unique PLFA distributions kidneys raised linoleic without pro-inflammatory n-6 PUFAs. Sunflower saturated palmitic acid, as opposed rise monounsaturated oleic acid. also significantly improved profiles, reducing LDL increasing HDL levels enhancing cardiovascular indices. Conclusions: study demonstrates that impact organ-specific linseed enriching renal PUFAs, palm induce distinct modifications Moreover, offers notable cardioprotective benefits due favorable profile changes. These findings highlight importance fat selection achieving balanced metabolism suggest diverse combinations may be essential optimizing health outcomes.

Язык: Английский

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Microbiota-induced lipid peroxidation impairs obeticholic acid-mediated antifibrotic effect towards nonalcoholic steatohepatitis in mice

Redox Biology, Год журнала: 2022, Номер 59, С. 102582 - 102582

Опубликована: Дек. 22, 2022

Obeticholic acid (OCA) has been examined to treat non-alcoholic steatohepatitis (NASH), but unsatisfactory antifibrotic effect and deficient responsive rate in recent phase III clinical trial. Using a prolonged western diet-feeding murine NASH model, we show that OCA-shaped gut microbiota induces lipid peroxidation impairs its anti-fibrotic effect. Mechanically, Bacteroides enriched by OCA deconjugates tauro-conjugated bile acids generate excessive chenodeoxycholic (CDCA), resulting liver ROS accumulation. We further elucidate reduces triglycerides containing polyunsaturated fatty (PUFA-TGs) levels, whereas elevates free PUFAs phosphatidylethanolamines PUFA (PUFA-PEs), which are susceptible be oxidized peroxides (notably arachidonic (ARA)-derived 12-HHTrE), inducing hepatocyte ferroptosis activating hepatic stellate cells (HSCs). Inhibiting with pentoxifylline (PTX) rescues of OCA, suggesting combination inhibitor could potential pharmacological approach NASH-fibrosis.

Язык: Английский

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Fruit bioactive compounds: Effect on lactic acid bacteria and on intestinal microbiota

Food Research International, Год журнала: 2022, Номер 161, С. 111809 - 111809

Опубликована: Авг. 27, 2022

Язык: Английский

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Oxidation of Polyunsaturated Fatty Acids as a Promising Area of Research in Infertility

Antioxidants, Год журнала: 2022, Номер 11(5), С. 1002 - 1002

Опубликована: Май 19, 2022

In this review, the role of fatty acids (FA) in human pathological conditions, infertility particular, was considered. FA and FA-derived metabolites modulate cell membrane composition, lipid microdomains signaling. Moreover, such molecules are involved death, immunological responses inflammatory processes. Human health several conditions specifically associated with both dietary profiles. The metabolism sperm spermatogenesis has recently been investigated. Cumulative findings indicate F2 isoprostanes (oxygenated products from arachidonic acid metabolism) resolvins (lipid mediators resolution inflammation) as promising biomarkers for evaluation semen follicular fluid quality. Advanced knowledge field could lead to new scenarios treatment infertility.

Язык: Английский

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Gut microbiota regulation of inflammatory cytokines and microRNAs in diabetes-associated cognitive dysfunction

Applied Microbiology and Biotechnology, Год журнала: 2023, Номер 107(23), С. 7251 - 7267

Опубликована: Сен. 21, 2023

Язык: Английский

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Obesity during preclinical Alzheimer's disease development exacerbates brain metabolic decline

Journal of Neurochemistry, Год журнала: 2023, Номер 168(5), С. 801 - 821

Опубликована: Июнь 30, 2023

Abstract Alzheimer's disease (AD) is the most common form of dementia. Obesity in middle age increases AD risk and severity, which alarming given that obesity prevalence peaks at rates are accelerating worldwide. Midlife, but not late‐life risk, suggesting this interaction specific to preclinical AD. pathology begins age, with accumulation amyloid beta (Aβ), hyperphosphorylated tau, metabolic decline, neuroinflammation occurring decades before cognitive symptoms appear. We used a transcriptomic discovery approach young adult (6.5 months old) male female TgF344‐AD rats overexpress mutant human precursor protein presenilin‐1 wild‐type (WT) controls determine whether inducing high‐fat/high‐sugar “Western” diet during brain dysfunction dorsal hippocampus (dHC), region vulnerable effects early Analyses dHC gene expression data showed dysregulated mitochondrial neurotransmission pathways, up‐regulated genes involved cholesterol synthesis. Western amplified number were different between WT added pathways noradrenergic signaling, inhibition synthesis, decreased intracellular lipid transporters. Importantly, impaired dHC‐dependent spatial working memory rats, confirming dietary intervention accelerated decline. To examine later consequences transcriptional dysregulation, we measured monoamine levels older (13 both sexes after long‐term chow or consumption. Norepinephrine (NE) abundance was significantly NE turnover increased, attenuated AD‐induced turnover. Collectively, these findings indicate prodromal impairs memory, potentiates decline likely leading an overproduction cholesterol, interferes compensatory transmission. image

Язык: Английский

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Towards early detection of neurodegenerative diseases: A gut feeling

Frontiers in Cell and Developmental Biology, Год журнала: 2023, Номер 11

Опубликована: Фев. 7, 2023

The gastrointestinal tract communicates with the nervous system through a bidirectional network of signaling pathways called gut-brain axis, which consists multiple connections, including enteric system, vagus nerve, immune endocrine signals, microbiota, and its metabolites. Alteration communications in axis is emerging as an overlooked cause neuroinflammation. Neuroinflammation common feature pathogenic mechanisms involved various neurodegenerative diseases (NDs) that are incurable debilitating conditions resulting progressive degeneration death neurons, such Alzheimer Parkinson diseases. NDs leading global disability, incidences expected to increase following decades if prevention strategies successful treatment remain elusive. To date, etiology unclear due complexity involving genetic environmental factors, diet microbiota. Emerging evidence suggests changes diet, alteration deregulation metabolism intestinal epithelium influence inflammatory status neurons linked disease insurgence progression. This review will describe players so-called diet-microbiota-gut-brain (DMGB) context NDs. We report recent findings from studies model organisms rodents fruit flies support role diets, commensals, epithelial functions primary regulator brain health. finish discussing pivotal metabolisms cellular organelles mitochondria peroxisomes maintaining DMGB how latter can be used early makers novel therapeutic targets.

Язык: Английский

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