Journal of Dietary Supplements, Год журнала: 2025, Номер unknown, С. 1 - 16

Опубликована: Март 27, 2025

We examined the influence of dietary α-lipoic acid (LA; R enantiomer) supplementation in obese-complicated pregnancies on maternal postpartum body weight and metabolic health. Forty-eight female Sprague-Dawley rats were randomized into three groups throughout pre-pregnancy, gestation, lactation: (i) a low-calorie control diet (CON); (ii) high calorie obesity-inducing (HC); or (iii) HC with 0.25% LA (HC+LA). Following offspring weaning, all mothers switched to CON for period 140 days assess markers HC-fed showed excessive (p < 0.05) gestational gain (GWG), higher weight, reduced glycemic (lower glucose:insulin ratio) = 0.06) hepatic cholesterol concentration versus mothers. In contrast, HC+LA demonstrated lower experimental compared mothers, primarily due marked reduction GWG. Although did not protect > against control, it alter several aspects lipid metabolism including serum HDL-C which was mediated partly through low-density lipoprotein receptor expression. conclude that obesity during pregnancy leads longer-term detrimental impact even after switching diet. Maternal may be able partially offset these effects, likely by protecting GWG pregnancy. However, further work is required determine consequences LA-supplemented

Язык: Английский