Nanomedicine-Unlocked Radiofrequency Dynamic Therapy Dampens Incomplete Radiofrequency Ablation-Arised Immunosuppression to Suppress Cancer Relapse

Biomaterials, Год журнала: 2025, Номер 317, С. 123087 - 123087

Опубликована: Янв. 2, 2025

Язык: Английский

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Regulated cell death‐amplified sonodynamic anti‐tumor immune nanotherapeutics

BMEMat, Год журнала: 2024, Номер unknown

Опубликована: Март 4, 2024

Abstract Nanomedicine‐assisted sonodynamic therapy (SDT) has emerged as one of the most promising cancer therapies due to its unique advantages high penetration, non‐radiation, and excellent oxidative stress effect, but always suffered from self‐protection mechanism apoptosis resistance characteristics evolutionarily mutated cells. Regulated cell death (RCD) received increasing attention in precision treatments because significant role synergistically sensitizing reversing immunosuppressive microenvironment during SDT nanomedicine‐triggered immunogenic death. Herein, paradigmatic research RCD‐augmented tumor immunotherapeutics are typically introduced, such autophagy blockade, ferroptosis targeting, pyroptosis induction, necroptosis initiation, cuproptosis actuation, PANoptosis trigger, coordinated anti‐tumor mechanisms discussed detail. Multiple analysis focusing on currently unsolved problems future development prospects RCD‐based nano‐oncology medicine also prospected further strengthen expand scope therapeutic applications.

Язык: Английский

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Tumor Microenvironment‐Selective Sol–Gel Mineralization of ROS‐Responsive Stretchable and Conductive Hydrogel

Advanced Functional Materials, Год журнала: 2024, Номер 34(37)

Опубликована: Апрель 11, 2024

Abstract Cancer cell‐triggered sol–gel transformation of mineralized hydrogel (PAA‐MnO 2 ) is designed as a facile strategy for cancer detection by manipulating the mineralization process in presence cells. The polyacrylic acid (PAA) with calcium phosphate via carboxyl‐Ca 2+ complex initially inhibited incorporation reactive oxygen species (ROS)‐sensitive manganese oxide (MnO polymer dots (PDs). In this system, can be induced after cleaving MnO into Mn high ROS levels cells, forming PAA‐MnO and resulting naked‐eye system monitoring. Naked‐eye monitoring ROS‐responsive performed using circulator device containing circulating cells to discriminate (HeLa, PC‐3, B16F10) from normal (CHO‐K1). With PDs, not only provides physical (stretchability, viscosity) but also fluorescence‐recovery electroconductivity changes at different cancer‐cell concentrations (10 4 –10 6 mL −1 ), including distinct strain–pressure responses that wirelessly monitored smartphones. Furthermore, vivo, experiments suggest formed tumor‐bearing mice owing its excellent ROS‐scavenging activity tumor site, confirmed SOD2 gene‐expression analysis. Thus, unique approach potentially enable simple effective future point‐of‐care diagnostics.

Язык: Английский

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Single-atom nanozymes shines diagnostics of gastrointestinal diseases

Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)

Опубликована: Май 25, 2024

Various clinical symptoms of digestive system, such as infectious, inflammatory, and malignant disorders, have a profound impact on the quality life overall health patients. Therefore, chase for more potent medicines is both highly significant urgent. Nanozymes, novel class nanomaterials, amalgamate biological properties nanomaterials with catalytic activity enzymes, been engineered various biomedical applications, including complex gastrointestinal diseases (GI). Particularly, because their distinctive metal coordination structure ability to maximize atom use efficiency, single-atom nanozymes (SAzymes) atomically scattered centers are becoming viable substitute natural enzymes. Traditional nanozyme design strategies no longer able meet current requirements efficient diverse SAzymes due diversification complexity preparation processes. As result, this review emphasizes concept synthesis strategy SAzymes, corresponding bioenzyme-like activities, superoxide dismutase (SOD), peroxidase (POD), oxidase (OXD), catalase (CAT), glutathione (GPx). Then application in GI illnesses summarized, which should encourage further research into achieve better characteristics.

Язык: Английский

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Engineered Cancer Nanovaccines: A New Frontier in Cancer Therapy

Nano-Micro Letters, Год журнала: 2024, Номер 17(1)

Опубликована: Сен. 30, 2024

Abstract Vaccinations are essential for preventing and treating disease, especially cancer nanovaccines, which have gained considerable interest recently their strong anti-tumor immune capabilities. Vaccines can prompt the system to generate antibodies activate various cells, leading a response against tumor tissues reducing negative effects recurrence risks of traditional chemotherapy surgery. To enhance flexibility targeting vaccines, nanovaccines utilize nanotechnology encapsulate or carry antigens at nanoscale level, enabling more controlled precise drug delivery responses. Cancer function by encapsulating tumor-specific tumor-associated within nanomaterials. The small size these nanomaterials allows T dendritic thereby eliciting potent response. In this paper, we focus on classification carriers roles different target clinically tested discussing strategies effectively inducing cytotoxic lymphocytes responses optimizing antigen presentation, while also looking ahead translational challenges moving from animal experiments clinical trials.

Язык: Английский

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Photoirradiation‐ and Extracellular‐Matrix‐Encouraged Photon‐Transition Switching Regulates Spatiotemporal Sequential Photoimmunotherapy

Small Structures, Год журнала: 2025, Номер unknown

Опубликована: Янв. 14, 2025

As two main phototherapy means, photodynamic therapy (PDT) and photothermal (PTT) have different photon‐transition avenues decided by the aggregation state of photosensitizers (PSs), thus PDT or PTT efficiency can be regulated regulating PSs aggregation. A co‐assembly formulation consisting IR780 iodide pentafluorophenyl trifluoroacetate is constructed through intermolecular interactions, followed coating with hyaluronic acid. Initially, uniform distribution favors more reactive oxygen species birth to implement when entering cells since its avenue sequential process intersystem crossing transfer–collision energy transfer predominant. After hyaluronidase laser irradiation‐induced structural collapse co‐assembly, free aggregates due hydrophobic interactions even though they are excreted out cells, then, these produce heat nonradiative relaxation execute PTT. Such a spatiotemporal PDT–PTT encourages antitumor immune responses mitigates immunosuppression, accomplishing photoimmunotherapy against breast cancer progression. Through such tumor microenvironment‐adaptable laser‐duration‐decided alteration, switching insights provided into single PSs‐mediated photoimmunotherapy.

Язык: Английский

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Low‐Intensity Focused Ultrasound‐Responsive, Phase‐Change Nanodroplets to Remodel Macrophage Polarization and Enhance PD‐L1 Blockade Therapy

Small Structures, Год журнала: 2025, Номер unknown

Опубликована: Март 8, 2025

Immune checkpoint blockade (ICB) therapy is a promising treatment that has shown significant effects in certain refractory and advanced cancers. However, not all patients respond to ICB therapy. The tumor microenvironment (TME) helps tumors evade immune surveillance attack, contributing the low response rate M1 macrophages primarily exert antitumor within TME, whereas M2 support growth evasion through various mechanisms, making them crucial component of TME. To reduce macrophages, mitigate ultimately enhance therapy, perfluoropentane (PFP) used as phase‐change material hematoporphyrin monomethyl ether incorporated into nanodroplets (NDs). With mannose modification on their surface, these NDs can effectively target denoted MPH@NDs. When exposed low‐intensity focused ultrasound, MPH@NDs cause mechanical injury produce reactive oxygen species. This will lead remodeling distribution transforming it proinflammatory microenvironment. enhances cytotoxic T lymphocytes accumulation tumors, remodels improves PD‐L1 immunotherapy efficacy. demonstrate potential enhancing suppressing distant metastasis.

Язык: Английский

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Macrophages-mediated delivery of protoporphyrin for sonodynamic therapy of rheumatoid arthritis

Ultrasonics Sonochemistry, Год журнала: 2024, Номер 107, С. 106928 - 106928

Опубликована: Май 27, 2024

Rheumatoid arthritis (RA) is a chronic systemic inflammatory disease characterized by infiltration of cells, hyperplasia synovium, and destruction the joint cartilage. Owing to low drug delivery efficiency limited immunosuppression effect, complete cure for RA remains formidable challenge. Here, we show that live macrophages (Mφs) carrying protoporphyrin-loaded Fe

Язык: Английский

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Gelation embolism agents suppress clinical TACE-incited pro-metastatic microenvironment against hepatocellular carcinoma progression

EBioMedicine, Год журнала: 2024, Номер 109, С. 105436 - 105436

Опубликована: Окт. 31, 2024

Current embolic agents in transcatheter arterial chemoembolization (TACE) of hepatocellular carcinoma (HCC) encounter instability and easy leakage, discounting TACE efficacy with residual HCC. Moreover, clinical aggravates hypoxia pro-metastatic microenvironments, rendering patients HCC poor prognosis.

Язык: Английский

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Toward Ultrasound Molecular Imaging of Endothelial Dysfunction in Diabetes: Targets, Strategies, and Challenges

ACS Applied Bio Materials, Год журнала: 2024, Номер 7(3), С. 1416 - 1428

Опубликована: Фев. 23, 2024

Diabetes vasculopathy is a significant complication of diabetes mellitus (DM), and early identification timely intervention can effectively slow the progression. Accumulating studies have shown that causes vascular complications directly or indirectly through variety mechanisms. Direct imaging endothelial molecular changes not only identifies stage but also sheds light on precise treatment. Targeted ultrasound contrast agent (UCA)-based (UMI) noninvasively detect expression status biomarkers overexpressed in vasculature, thereby being potential strategy for diagnosis treatment response evaluation DM. Amounts efforts been focused targets expressed manufacturing strategies targeted UCA, clinical translation therapeutic efficacy both micro- macrovasculopathy This review summarizes latest research progress endothelium-targeted UCA discusses their promising future challenges theranostics.

Язык: Английский

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