Hybrid Metal Catalysts as Valuable Tools in Organic Synthesis: An Overview of the Recent Advances in Asymmetric C─C Bond Formation Reactions DOI Creative Commons
Isabella Rimoldi, Giulia Coffetti, Raffaella Gandolfi

и другие.

Molecules, Год журнала: 2024, Номер 29(21), С. 5090 - 5090

Опубликована: Окт. 28, 2024

Carbon–carbon bond formation represents a key reaction in organic synthesis, resulting paramount importance for constructing the carbon backbone of molecules. However, traditional metal-based catalysis, despite its advantages, often struggles with issues related to efficiency, selectivity, and sustainability. On other hand, while biocatalysis offers superior selectivity due an extraordinary recognition process substrate, scope applicable reactions remains somewhat limited. In this context, Artificial Metalloenzymes (ArMs) Metallo Peptides (MPs) offer promising not fully explored solution, merging two fields transition metal catalysis biotransformations, by inserting catalytically active cofactor into customizable protein scaffold or coordinating ion directly short tunable amino acid (Aa) sequence, respectively. As result, these hybrid catalysts have gained attention as valuable tools challenging catalytic transformations, providing systems new-to-nature properties synthesis. This review overview recent advances development ArMs MPs, focusing on their application asymmetric carbon–carbon bond-forming reactions, such carbene insertion, Michael additions, Friedel–Crafts cross-coupling cyclopropanation, underscoring versatility synthesizing biologically relevant compounds.

Язык: Английский

Amyloid inspired single amino acid (phenylalanine)-based supramolecular functional assemblies: from disease to device applications DOI
Sandeep Kumar Vishwakarma, Om Shanker Tiwari, Ruchi Shukla

и другие.

Chemical Society Reviews, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

This review highlights recent advances in phenylalanine supramolecular assemblies, emphasizing their applications pathology and device technology underscoring significance for future innovations.

Язык: Английский

Процитировано

2
Schiff Base Mediated Food-Derived Peptide Supramolecular Self-Assembly as Curcumin Carriers DOI

Longjiang Tian,

Xiangyu You, Jingbo Liu

и другие.

Journal of Agricultural and Food Chemistry, Год журнала: 2024, Номер unknown

Опубликована: Дек. 7, 2024

The fusion assembly strategy of supramolecular chemistry combined with dynamic covalent has provided novel insights into the design precision nutrition and intelligent drug delivery carriers. This work involved development a self-assembly originating from entropy- enthalpy-driven bonding on Schiff bases between egg white-derived peptide Gln-Ile-Gly-Leu-Phe (QIGLF) glutaraldehyde (GA), denoted QIGLF–GA. exhibited outstanding characteristics multiwavelength autofluorescence properties. Benefiting potent facilitation interaction base noncovalent force network, QIGLF–GA was afforded an encapsulation capacity curcumin (Cur) more than 22% (≫ 10%) rationally inhibited P-glycoprotein-mediated cellular efflux markedly elevated efficacy Cur in overcoming intestinal epithelial absorption barrier to circulation help endocytosis. Furthermore, QIGLF–GA-Cur features responsive release under weakly acidic conditions, which dramatically contributes intracellular bioavailability Cur.

Язык: Английский

Процитировано

2
Metal Cross-Linked Supramolecular Gel Noodles: Structural Insights and Antibacterial Assessment DOI Creative Commons
Dipankar Ghosh,

Sophie Coulter,

Garry Laverty

и другие.

Biomacromolecules, Год журнала: 2024, Номер 25(5), С. 3169 - 3177

Опубликована: Апрель 29, 2024

Achieving precise control over gelator alignment and morphology is crucial for crafting tailored materials supramolecular structures with distinct properties. We successfully aligned the self-assembled micelles formed by a functionalized dipeptide 2NapFF into long 1-D "gel noodles" cross-linking divalent metal chlorides. identify most effective cross-linker alignment, enhancing mechanical stability, imparting functional Our study shows that Group 2 ions are particularly suited creating mechanically robust yet flexible gel noodles because of their ionic nondirectional bonding carboxylate groups. In contrast, covalent nature high directional bonds d-block carboxylates tend to disrupt self-assembly 2NapFF. Furthermore, 2NapFF-Cu demonstrated selective antibacterial activity, indicating potent property copper(II) ion preserved within cross-linked system. By merging insights molecular extrusion processing, integrating specific functionalities, we illustrate how versatility dipeptide-based gels can be utilized in next-generation soft materials.

Язык: Английский

Процитировано

1
Self-Sorting in Multicomponent Supramolecular Gels Using Different Assembly Triggers and Calcium Ion-Induced Diffusion Patterning DOI Creative Commons
Chayanan Tangsombun, David K. Smith

Chemistry of Materials, Год журнала: 2024, Номер 36(10), С. 5050 - 5062

Опубликована: Май 14, 2024

This paper investigates self-sorting and triggered assembly of multicomponent gels that combine sorbitol-based low-molecular-weight gelator (LMWG) DBS-CONHNH2 peptide-based LMWG Nap-FF, with the Nap-FF being either using glucono-δ-lactone (GdL) to lower pH or CaCl2. Changing triggers alters way assembles on molecular scale as its acid form calcium salt, leading different nanoscale networks rheological behaviors. The choice trigger impacts properties two-component formed DBS-CONHNH2. Using trigger, LMWGs self-sort level into their own distinct assemblies. However, when a GdL sheet-like assemblies encourage assembly, two interacting one another network result interactions between acylhydrazide carboxylic acid. Conversely, CaCl2 fibrillar are independent level, bound in carboxylate unable interact As such, GdL-triggering leads molecular-level network-level coassembly, while CaCl2-triggering both self-sorting. Injecting preformed gel, followed by diffusion, creates dynamic, evolving, spatially-resolved self-sorted gels, stiffnesses differing 2 orders magnitude domains. Given mild, biocompatible nature CaCl2, it is suggested this ion diffusion approach spatiotemporally resolved patterning multidomain may have future relevance cell-based studies.

Язык: Английский

Процитировано

1
Supramolecular Conductive Hydrogels for Tissue Engineering Applications DOI

Aashwini Bhavsar,

Falguni Pati, Priyadarshi Chakraborty

и другие.

ChemBioChem, Год журнала: 2024, Номер 26(1)

Опубликована: Окт. 27, 2024

Abstract Owing to their unique attributes, including reversibility, specificity, directionality, and tunability, supramolecular biomaterials have evolved as an excellent alternative conventional like polymers, ceramics, metals. Supramolecular hydrogels, in particular, garnered significant interest because fibrous architecture, high water content, interconnected 3D network resemble the extracellular matrix some extent. Consequently, hydrogels been used develop for tissue engineering. conductive combine advantages of soft materials with electrical properties metals, making them highly relevant electrogenic Given versatile applications these it is essential periodically review high‐quality research this area. In review, we focus on recent advances particularly We discuss components highlight notable reports use cardiac, skin, neural Additionally, outline potential future developments field.

Язык: Английский

Процитировано

0
Hybrid Metal Catalysts as Valuable Tools in Organic Synthesis: An Overview of the Recent Advances in Asymmetric C─C Bond Formation Reactions DOI Creative Commons
Isabella Rimoldi, Giulia Coffetti, Raffaella Gandolfi

и другие.

Molecules, Год журнала: 2024, Номер 29(21), С. 5090 - 5090

Опубликована: Окт. 28, 2024

Carbon–carbon bond formation represents a key reaction in organic synthesis, resulting paramount importance for constructing the carbon backbone of molecules. However, traditional metal-based catalysis, despite its advantages, often struggles with issues related to efficiency, selectivity, and sustainability. On other hand, while biocatalysis offers superior selectivity due an extraordinary recognition process substrate, scope applicable reactions remains somewhat limited. In this context, Artificial Metalloenzymes (ArMs) Metallo Peptides (MPs) offer promising not fully explored solution, merging two fields transition metal catalysis biotransformations, by inserting catalytically active cofactor into customizable protein scaffold or coordinating ion directly short tunable amino acid (Aa) sequence, respectively. As result, these hybrid catalysts have gained attention as valuable tools challenging catalytic transformations, providing systems new-to-nature properties synthesis. This review overview recent advances development ArMs MPs, focusing on their application asymmetric carbon–carbon bond-forming reactions, such carbene insertion, Michael additions, Friedel–Crafts cross-coupling cyclopropanation, underscoring versatility synthesizing biologically relevant compounds.

Язык: Английский

Процитировано

0