Synergistic Effects of Radical Distributions of Soluble and Insoluble Polymers within Electrospun Nanofibers for an Extending Release of Ferulic Acid

Polymers, Год журнала: 2024, Номер 16(18), С. 2614 - 2614

Опубликована: Сен. 15, 2024

Polymeric composites for manipulating the sustained release of an encapsulated active ingredient are highly sought after many practical applications; particularly, water-insoluble polymers and core–shell structures frequently explored to manipulate behaviors drug molecules over extended time period. In this study, electrospun nanostructures were utilized develop a brand-new strategy tailor spatial distributions both insoluble polymer (ethylcellulose, EC) soluble (polyvinylpyrrolidone, PVP) within nanofibers, thereby extended-release loaded ingredient, ferulic acid (FA). Scanning electron microscopy transmission assessments revealed that all prepared nanofibers had linear morphology without beads or spindles, those from coaxial processes obvious structure. X-ray diffraction attenuated total reflectance Fourier transform infrared spectroscopic tests confirmed FA fine compatibility with EC PVP, presented in amorphous state. vitro dissolution indicated radical (decreasing shell core) PVP (increasing able play their important role elaborately. On one hand, F3 advantages homogeneous composite F1 higher content solutions inhibit initial burst provide longer period release. other F2 core negative tailing-off The key element was water permeation rates, controlled by ratios polymers. new based on structure paves way developing wide variety polymeric heterogeneous realizing desired functional performances.

Язык: Английский

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Shell Distribution of Vitamin K3 within Reinforced Electrospun Nanofibers for Improved Photo-Antibacterial Performance

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(17), С. 9556 - 9556

Опубликована: Сен. 3, 2024

Personal protective equipment (PPE) has attracted more attention since the outbreak of epidemic in 2019. Advanced nano techniques, such as electrospinning, can provide new routes for developing novel PPE. However, electrospun antibacterial PPE is not easily obtained. Fibers loaded with photosensitizers prepared using single-fluid electrospinning have a relatively low utilization rate due to influence embedding and their inadequate mechanical properties. For this study, monolithic nanofibers core–shell were compared. Monolithic F1 fibers comprising polyethylene oxide (PEO), poly(vinyl alcohol-co-ethylene) (PVA-co-PE), photo-antibacterial agent vitamin K3 (VK3) created blending process. Core–shell F2 coaxial which extensible material PEO was set core section, composite consisting PEO, PVA-co-PE, VK3 shell section. Both designed structural properties had an average diameter approximately 1.0 μm, determined scanning electron microscopy transmission microscopy. amorphously dispersed within polymeric matrices compatible manner, revealed X-ray diffraction Fourier transform infrared spectroscopy. higher tensile strength 2.917 ± 0.091 MPa, whereas longer elongation break 194.567 0.091%. Photoreaction tests showed that, adjustment, could produce 0.222 μmol/L ·OH upon illumination. slightly better performance than fibers, inhibition zones 1.361 0.012 cm 1.296 0.022 E. coli S. aureus, respectively, but less VK3. The intentional tailoring components compositions nanostructures improve process–structure–performance relationship potential sunlight-activated

Язык: Английский

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Synergistic improvements of properties of cellulose acetate based curcumin@TiO2 nanofibers via triaxial electrospinning

Chemical Engineering Journal, Год журнала: 2025, Номер 506, С. 160117 - 160117

Опубликована: Янв. 1, 2025

Язык: Английский

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Advancements in Wound Dressing Materials: Highlighting Recent Progress in Hydrogels, Foams, and Antimicrobial Dressings

Gels, Год журнала: 2025, Номер 11(2), С. 123 - 123

Опубликована: Фев. 7, 2025

Recent advancements in wound dressing materials have significantly improved acute and chronic management by addressing challenges such as infection control, moisture balance, enhanced healing. Important progress has been made, especially with hydrogels, foams, antimicrobial for creating optimized dressings. Hydrogels are known maintaining optimal levels, while foam dressings excellent exudate absorbents. Meanwhile, incorporates various agents to reduce risks. These options healing time focusing on customized patient needs. Therefore, this review highlights the newest research prototypes applications, emphasizing their particular benefits clinical importance. Innovations stimuli-responsive hydrogels hybrid bioengineered composites discussed relation properties, including responsiveness pH, temperature, glucose, or enzymes drug delivery precision. Moreover, ongoing trials included, demonstrating potential of emerging solutions be soon translated from laboratory settings. By discussing interdisciplinary approaches that integrate advanced materials, nanotechnology, biological insights, work provides a contemporary framework patient-centric, efficient care strategies.

Язык: Английский

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Research Advances in Electrospun Nanofiber Membranes for Non-Invasive Medical Applications

Micromachines, Год журнала: 2024, Номер 15(10), С. 1226 - 1226

Опубликована: Сен. 30, 2024

Non-invasive medical nanofiber technology, characterized by its high specific surface area, biocompatibility, and porosity, holds significant potential in various domains, including tissue repair biosensing. It is increasingly becoming central to healthcare offering safer more efficient treatment options for contemporary medicine. Numerous studies have explored non-invasive nanofibers recent years, yet a comprehensive overview of the field remains lacking. In this paper, we provide summary applications electrospun fields, considering multiple aspects perspectives. Initially, introduce electrospinning nanofibers. Subsequently, detail their health, health monitoring, personal protection, thermal regulation, wound care, highlighting critical role improving human health. Lastly, paper discusses current challenges associated with offers insights into future development trajectories.

Язык: Английский

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Metal‐Protein Hybrid Materials: Unlocking New Frontiers in Biomedical Applications

Advanced Healthcare Materials, Год журнала: 2025, Номер unknown

Опубликована: Янв. 7, 2025

Abstract Metal‐protein hybrid materials represent a novel class of functional that exhibit exceptional physicochemical properties and tunable structures, rendering them remarkable applications in diverse fields, including engineering, biocatalysis, biosensing, biomedicine. The design development multifunctional biocompatible metal‐protein have been the subject extensive research key aspiration for practical clinical settings. This review provides comprehensive analysis strategies, intrinsic properties, biomedical these materials, with specific emphasis on their potential cancer therapy, drug vaccine delivery, antibacterial treatments, tissue regeneration. Through rational design, stable can be synthesized using straightforward methods, enabling therapeutic, immunomodulatory, other desired functionalities. Finally, outlines existing limitations challenges associated evaluates translation, providing insights into implementation within applications.

Язык: Английский

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Electroactive Asymmetric Dressing for Spatiotemporal Deep Burn Scarless Healing and Management

Advanced Healthcare Materials, Год журнала: 2025, Номер unknown

Опубликована: Янв. 10, 2025

Burn care and treatment differ markedly from other types of wounds, as they are significantly more prone to infections struggle maintain fluid balance post-burn. Moreover, the limited self-healing abilities exacerbate likelihood scar formation, further complicating recovery process. To tackle these issues, an asymmetric wound dressing comprising a quercetin-loaded poly(3-hydroxybutyrate-co-4-hydroxybutyrate) (P34HB@Qu) hydrophilic layer zinc oxide nanoparticle-loaded, thermally treated polyvinylidene fluoride (HPVDF@ZnO) hydrophobic is designed. This provided antibacterial property exudate management in early stages burn treatment, preventing infection maintaining moisture at site. As healing progresses, electroactive properties HPVDF@ZnO quercetin P34HB@Qu synergistically regulate cell migration differentiation, accelerating facilitating scar-free regeneration. Furthermore, assisted regeneration skin appendages. study underscores full-cycle strategy versatile dressings for spatiotemporal injury scarless healing.

Язык: Английский

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Synthesis and Evaluation of PCL/Chitosan/CQD‐Fe Magnetic Nanocomposite for Wound Healing: Emphasis on Gene Expression

Engineering in Life Sciences, Год журнала: 2025, Номер 25(1)

Опубликована: Янв. 1, 2025

ABSTRACT The development of an effective and rapid method for healing the skin is crucial importance. In this study, we prepared a porous scaffold made polycaprolactone (PCL) carbon quantum dots (CQDs), Fe, Chitosan (Cs) as core to cover skin. Then evaluated antibacterial, biocompatibility, wound properties well expression genes in healing. PCL/Cs/CQD‐Fe was synthesized via electrospinning morphology, functional groups, structure through Fourier transform infrared spectroscopy (FTIR), scanning electron microscope (SEM), x‐ray diffraction (XRD). viability L929 fibroblast stem cells obtained. antibacterial effect, efficiency were investigated minimum inhibitory concentration (MIC), (3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide (MTT), tissue analysis. relative platelet‐derived growth factor (PDGF), transforming beta (TGF‐β), matrix metalloproteinase‐1 (MMP1) assessed RT‐PCR. results SEM showed successful integration PCL with CQD‐Fe Cs. mean size nanocomposite range 0.135–32.6 nm. FTIR formation link between CQD nanoparticles Fe. vibrating‐sample magnetometer (VSM) proved super para magnetism magnetic (0.38 emu/g). MIC Cs/CQD‐Fe against Staphylococcus aureus Escherichia coli bacteria 0.08 0.04 µg/mL, respectively. TGF‐β PDGF group 0.05 0.015 on day 5 0.18 0.34 15 significantly increased after days, whereas MMP1 0.63 0.12 decreased days. According histological analysis, thickest layer Day pertained group. Our findings indicated that can improve regeneration due its non‐toxicity. This biocompatible be used covering

Язык: Английский

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Synthesis of PVA-Based Hydrogels for Biomedical Applications: Recent Trends and Advances

Gels, Год журнала: 2025, Номер 11(2), С. 88 - 88

Опубликована: Янв. 23, 2025

There is ongoing research for biomedical applications of polyvinyl alcohol (PVA)-based hydrogels; however, the execution this has not yet been achieved at an appropriate level commercialization. Advanced perception necessary design and synthesis suitable materials, such as PVA-based hydrogel applications. Among polymers, drawn great interest in owing to their attractive potential with characteristics good biocompatibility, mechanical strength, apposite water content. By designing approach investigating structure, hydrogels can attain superb cytocompatibility, flexibility, antimicrobial activities, signifying that it a candidate tissue engineering regenerative medicine, drug delivery, wound dressing, contact lenses, other fields. In review, we highlight current progresses on explaining diverse usage across variety areas. We explain numerous techniques related phenomena based these materials. This review may stipulate wide reference future acumens materials extensive

Язык: Английский

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Conductive, adhesive, and biocompatible hydrogel sensor based on zwitterionic for effective wound healing and monitoring

Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 160235 - 160235

Опубликована: Фев. 1, 2025

Язык: Английский

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