Computers in Biology and Medicine, Год журнала: 2025, Номер 190, С. 110017 - 110017

Опубликована: Март 23, 2025

In the context of numerical simulations vascular system, local geometric uncertainties have not yet been examined in sufficient detail due to model complexity and associated large effort. Such are related modeling errors resulting from computed tomography imaging, segmentation meshing. This work presents a methodology systematically induce modifications perform number blood flow draw statistically relevant conclusions on most commonly employed quantities interest, such as rates or wall shear stress. The surface structured hexahedral mesh patient-specific aorta is perturbed by displacement maps defined via Gaussian random fields stochastically uncertainty boundary. Three different cases studied, with perturbation magnitude 0.25, 0.5 1.0mm. Valid, locally meshes constructed an elasticity operator that extends perturbations into interior. Otherwise, identical incompressible problems solved these meshes, taking physiological boundary conditions Carreau fluid parameters account. Roughly 300000 three-dimensional non-stationary performed for three estimate probability distributions interest. Convergence studies justify spatial resolution meshes. Overall, results suggest moderate result reasonable engineering accuracy (relative single-digit percentage range) higher sensitivity gradient-related measures, noting observed negligible.

Язык: Английский