Medicine in Microecology, Год журнала: 2024, Номер unknown, С. 100118 - 100118
Опубликована: Ноя. 1, 2024
Язык: Английский
Medicina Clínica, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
1
Nutrients, Год журнала: 2024, Номер 16(14), С. 2260 - 2260
Опубликована: Июль 13, 2024
We conducted a 12-week randomized double-blind placebo-controlled clinical trial to investigate the potential impact of Bifidobacterium bifidum (Bf-688) supplementation on attention-deficit/hyperactivity disorder (ADHD). Children with ADHD who were already receiving stable dose methylphenidate (MPH) treatment enrolled and randomly assigned two groups: one add-on Bf-688 (daily bacterial count 5 × 109 CFUs) (n = 51) other placebo 51). All participants underwent assessments using Conners’ Continuous Performance Test (CPT) Auditory Attention (CATA). Additionally, fecal samples collected at beginning (week 0) endpoint 12). Remarkably, group supplementation, but not group, exhibited significant improvements in omission errors CPT as well Hit reaction time both CATA. Gut microbiome analysis revealed increase Firmicutes Bacteroidetes ratio (F/B ratio) only group. Furthermore, we identified negative correlations between N-Glycan biosynthesis Our results demonstrate that probiotic supplement can enhance neuropsychological performance children ADHD, possibly by altering composition gut microbiota, ultimately leading reduced biosynthesis.
Язык: Английский
Процитировано
6
The Kaohsiung Journal of Medical Sciences, Год журнала: 2025, Номер unknown
Опубликована: Янв. 7, 2025
Attention-deficit/hyperactivity disorder (ADHD) is a common psychiatric condition among children and adolescents, often associated with high risk of comorbidities. Currently, ADHD diagnosis relies exclusively on clinical presentation patient history, underscoring the need for clinically relevant, reliable, objective biomarkers. Such biomarkers may enable earlier lead to improved treatment outcomes. Our research team has focused identifying potential by investigating its possible pathomechanisms, consideration aforementioned criteria. Given significant sex-related differences in prevalence (male predominance) age-related variability symptomatology, we explored role neuroendocrine systems ADHD. Specifically, examined epigenetic regulation mechanism involved pathogenesis developed diagnostic model based peripheral microRNA. Additionally, investigated microbiota dysbiosis pathophysiology provided novel insights into management. This paper presents summary our findings By analyzing blood, salivary, fecal samples, identified several promising that serve as parameters improving accuracy Further involving larger cohort studies required confirm reliability these
Язык: Английский
Процитировано
0
Nutrients, Год журнала: 2025, Номер 17(5), С. 857 - 857
Опубликована: Фев. 28, 2025
Background: Psychological disorders are prevalent in patients having undergone gastrointestinal cancer surgery, and their emotional status may further deteriorate during subsequent chemotherapy. Psychobiotics specific probiotics that have the unique characteristics of producing neuroactive substances thought to act on brain-gut axis. The aim present study was evaluate benefits a psychobiotic formula depression anxiety status, as well perceived stress, versus placebo chemotherapy course following surgery for cancer. Patients: enrolled patients, allocated groups, were assessed by means these psychometric tests: Beck's Depression Inventory Hamilton Rating 17-item Scale depression; General Anxiety Disorder-7 anxiety; Perceived Stress Scale-14 Item stress at three time-points: upon allocation [T1], after one month treatment [T2], two months thereafter [T3]. Results: In total, 266 included. One improved [i] 60.4% [48 depressed T1, reduced 16 T3]; [ii] 57.0% [72 26 [iii] [42 14 T3]. placebo-treated experienced deterioration all parameters studied, i.e., increased 62.9%, 39.7%, 142.5%. Conclusions: Based findings, it can be recognized has great potential every patient risk suffering from depression, anxiety, or surgery/chemotherapy
Язык: Английский
Процитировано
0
Medicina Clínica (English Edition), Год журнала: 2025, Номер 164(6), С. 295 - 304
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
International review of neurobiology, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Nutrients, Год журнала: 2024, Номер 16(21), С. 3706 - 3706
Опубликована: Окт. 30, 2024
: This review investigates the impact of bioactive molecules produced by probiotics on child health, focusing their roles in modulating gut microbiota, enhancing immune function, and supporting overall development. Key metabolites, including short-chain fatty acids (SCFAs), bacteriocins, exopolysaccharides (EPSs), vitamins, gamma-aminobutyric acid (GABA), are highlighted for ability to maintain regulate inflammation, support neurodevelopment.
Язык: Английский
Процитировано
3
Medicine, Год журнала: 2024, Номер 103(50), С. e40900 - e40900
Опубликована: Дек. 13, 2024
Pediatric obstructive sleep apnea (OSA) is a prevalent sleep-related breathing disorder associated with significant neurocognitive and behavioral impairments. Recent studies have highlighted the role of gut microbiota microbiota-gut-brain axis (MGBA) in influencing cognitive health children OSA. This narrative review aims to summarize current knowledge on relationship between microbiota, MGBA, function pediatric It also explores potential artificial intelligence machine learning advancing this field identifying novel therapeutic strategies. OSA dysbiosis, reduced microbial diversity, metabolic disruptions. MGBA mechanisms, such as endocrine, immune, neural pathways, link outcomes. Artificial methodologies offer promising tools uncover markers mechanisms deficits Future research should focus validating these findings through clinical trials developing personalized approaches targeting microbiota.
Язык: Английский
Процитировано
1
Foods, Год журнала: 2024, Номер 13(18), С. 2971 - 2971
Опубликована: Сен. 19, 2024
In recent years, due to growing interest in gut health, the potential benefits of probiotics on have received much attention. Probiotics, now readily available both dietary supplements and a variety foods, become focal point consumer health choices. This study aims explore impact consumer-related factors, including socio-demographic profiles, status, knowledge, acceptance products Hong Kong. A total 385 participants engaged survey, providing data for an in-depth analysis how these factors influence attitudes toward probiotics. Findings revealed general confidence safety among respondents; however, there was noticeable gap understanding. The highlighted correlation between knowledge specific attributes, with higher educational attainment positively linked greater awareness. Furthermore, research indicated that women exhibit consciousness propensity consumption compared men. Consequently, promoting enhanced education fostering increased awareness are crucial steps prevent misuse optimize outcomes.
Язык: Английский
Процитировано
0
Medicine in Microecology, Год журнала: 2024, Номер unknown, С. 100118 - 100118
Опубликована: Ноя. 1, 2024
Язык: Английский
Процитировано
0