Coordination metal complexes with Schiff bases: Useful pharmacophores with comprehensive biological applications

Inorganic Chemistry Communications, Год журнала: 2021, Номер 130, С. 108710 - 108710

Опубликована: Июнь 2, 2021

Язык: Английский

---

Fabrication, structural elucidation, theoretical, TD-DFT, vibrational calculation and molecular docking studies of some novel adenine imine chelates for biomedical applications

Journal of Molecular Liquids, Год журнала: 2022, Номер 365, С. 119961 - 119961

Опубликована: Июль 30, 2022

Язык: Английский

---

Recent Overview of Potent Antioxidant Activity of Coordination Compounds

Antioxidants, Год журнала: 2023, Номер 12(2), С. 213 - 213

Опубликована: Янв. 17, 2023

During recent decades, the complexation of organic ligands toward several metal ions s-p and d-block has been applied as a plan to enhance its antioxidant performance. Due their wide range beneficial impacts, coordination compounds are widely used in industries, specifically medicinal pharmaceutical fields. The activity is generally improved by chelation consequently knowing that characteristics both metals can lead development greatly active compounds. Chelation substitute for using traditional synthetic antioxidants, because chelates present benefits, including variety geometry, oxidation states, number, assist favor redox methods associated with action. As well understanding best studied anti-oxidative assets these compounds, involved free radical scavenging process protecting human organisms from opposing effects radicals. ability be assessed various interrelated systems. methodological modification offers most knowledge on property chelates. Colorimetric techniques used, though electron paramagnetic resonance (EPR) an alternative metallic since color does not affect results. Information about systems, restrictions, permits dependable valuation performance assisting application states wherever drugs required, such food protection, appropriate good-packaged foods, dietary supplements, others. Because new exhaustive analysis ligands, it become separate field research chemistry. investigation will respected providing foundation properties future tests building high-quality antioxidative

Язык: Английский

---

Synthesize, structural inspection, stoichiometry in solution and DFT calculation of some novel mixed ligand complexes: DNA binding, biomedical applications and molecular docking approach

Journal of Molecular Liquids, Год журнала: 2024, Номер 399, С. 124422 - 124422

Опубликована: Март 11, 2024

Язык: Английский

---

Fabrication, structural inspection, stability studies in solution and DFT calculations of some novel complexes drived from 4-(Benzothiazol-2-yliminomethyl)-phenol ligand: Pharmaceutical applications supported by molecular docking approach

Journal of Molecular Structure, Год журнала: 2025, Номер unknown, С. 141284 - 141284

Опубликована: Янв. 1, 2025

Язык: Английский

---

A Mechanistic Overview on Green Assisted Formulation of Nanocomposites and Their Multifunctional Role in Biomedical Applications

Heliyon, Год журнала: 2025, Номер 11(3), С. e41654 - e41654

Опубликована: Янв. 8, 2025

The importance of nanocomposites constantly attains attention because their unique properties all across the fields especially in medical perspectives. study green-synthesized has grown to be extremely fascinating field research. Nanocomposites are more promising than mono-metallic nanoparticles they exhibit synergistic effects. This review encapsulates current development formulation plant-mediated by using several plant species and impact secondary metabolites on biocompatible functioning. Phyto-synthesis produces diverse nanomaterials with biocompatibility, environment-friendliness, vivo actions, characterized varying sizes, shapes, biochemical nature. process is advantageous conventional physical chemical procedures. New studies have been conducted determine biomedical efficacy against various diseases. Unfortunately, there inadequate investigation into green-assisted nanocomposites. Incorporating phytosynthesized therapeutic interventions not only enhances healing processes but also augments host's immune defenses infections. highlights phytosynthesis applications, including antibacterial, antidiabetic, antiviral, antioxidant, antifungal, anti-cancer, other as well toxicity. explores mechanistic action achieve designated tasks. Biogenic for multimodal imaging potential exchange methods materials Well-designed utilized innovative theranostic agents subsequent objective efficiently diagnosing treating a variety human disorders.

Язык: Английский

---

Development of Some Novel Hydrophilic Schiff Base Complexes: Synthesis, Spectroscopic Characterization, and DFT Calculation DNA‐Binding and Biomedical Studies Supported by Molecular Docking Approach

Applied Organometallic Chemistry, Год журнала: 2025, Номер 39(3)

Опубликована: Фев. 25, 2025

ABSTRACT Several unique transition metal chelates of ESSA = sodium;4‐[(3‐ethoxy‐2‐hydroxy‐benzylidene)‐amino]‐benzenesulfonate and its Cu(II), Fe(III), VO(II), Pd(II) were developed. Various spectral physicochemical experiments carried out to ascertain the geometrical form compounds under exploration. Spectrum info imine azomethine ligand was employed for clarification alterations structure triggered by complex formation. The formation complexes deploying continuous variation molar ratio explored, findings coincided with those observed in solid compounds, a (M:L) being (1:2) all complexes, except is (1:1) metal‐to‐ligand ratio. Electronic spectra magnetic moments can be applied derive data concerning geometric formations. activation thermodynamic variables related thermal breakdown identified using Coats–Redfern approach. coordinates Cu(II) through square planner geometry, Fe(III) into octahedral VO(II) pyramidal based on correlation techniques used inquiry DFT calculation. novel tested DNA binding spectroscopy, viscosity, gel electrophoresis. Intercalation or replacement modes hypothesized their interaction CT‐DNA. Molecular docking studies conducted analyze protein‐generated compounds' affinity. antibacterial, anticancer, antioxidant properties evaluated vitro. ESSAPd excelled over free ineffective therapy.

Язык: Английский

---

Optimization for synthesized quinoline-based Cr3+, VO2+, Zn2+ and Pd2+complexes: DNA interaction, biological assay and in-silico treatments for verification

Journal of Molecular Liquids, Год журнала: 2021, Номер 339, С. 116797 - 116797

Опубликована: Июнь 24, 2021

Язык: Английский

---

Structural inspection for novel Pd(II), VO(II), Zn(II) and Cr(III)- azomethine metal chelates: DNA interaction, biological screening and theoretical treatments

Journal of Molecular Structure, Год журнала: 2021, Номер 1246, С. 131139 - 131139

Опубликована: Июль 22, 2021

Язык: Английский

---

Tailoring of some novel bis-hydrazone metal chelates, spectral based characterization and DFT calculations for pharmaceutical applications and in-silico treatments for verification

Journal of Molecular Structure, Год журнала: 2022, Номер 1264, С. 133263 - 133263

Опубликована: Май 11, 2022

Язык: Английский

---