Novel Ruthenium‐based Nitrosyl Complexes: NO Donation and Vasorelaxant Potentials for Cardiovascular Therapeutics DOI
Florêncio Sousa Gouveia Júnior, Eduardo H. S. Sousa,

Renally B. da Silva

и другие.

European Journal of Inorganic Chemistry, Год журнала: 2024, Номер 27(14)

Опубликована: Март 7, 2024

Abstract Nitrosyl ruthenium complexes have emerged as promising platforms for the controlled delivery of nitric oxide (NO) and nitroxyl (HNO), both which possess significant therapeutic implications. Considering this scenario, we synthesized characterized metal complex cis ‐[RuNO(phen) 2 (2MIM)] 3+ its precursors, where phen 2MIM correspond to 1,10‐phenantroline 2‐methylimidazole, respectively. Comprehensive structural elucidation was undertaken using a combination spectroscopic electrochemical methodologies, including XANES/EXAFS experiments. This data further validated through DFT computational analyses. We demonstrated that such compound can release NO HNO in presence thiol‐based substrates. Not only this, but same also under irradiation with visible light (λ=460 nm). The nitrosyl derivatives displayed marked vasodilatory capabilities evidenced assays involving isolated rat aorta rings. They exhibited commendable antioxidant activity free radical scavenging assays. Collectively, based on these data, is potential candidate, especially field cardiovascular pathology like atherosclerosis, thereby deserving in‐depth investigations.

Язык: Английский

Novel Ruthenium‐based Nitrosyl Complexes: NO Donation and Vasorelaxant Potentials for Cardiovascular Therapeutics DOI
Florêncio Sousa Gouveia Júnior, Eduardo H. S. Sousa,

Renally B. da Silva

и другие.

European Journal of Inorganic Chemistry, Год журнала: 2024, Номер 27(14)

Опубликована: Март 7, 2024

Abstract Nitrosyl ruthenium complexes have emerged as promising platforms for the controlled delivery of nitric oxide (NO) and nitroxyl (HNO), both which possess significant therapeutic implications. Considering this scenario, we synthesized characterized metal complex cis ‐[RuNO(phen) 2 (2MIM)] 3+ its precursors, where phen 2MIM correspond to 1,10‐phenantroline 2‐methylimidazole, respectively. Comprehensive structural elucidation was undertaken using a combination spectroscopic electrochemical methodologies, including XANES/EXAFS experiments. This data further validated through DFT computational analyses. We demonstrated that such compound can release NO HNO in presence thiol‐based substrates. Not only this, but same also under irradiation with visible light (λ=460 nm). The nitrosyl derivatives displayed marked vasodilatory capabilities evidenced assays involving isolated rat aorta rings. They exhibited commendable antioxidant activity free radical scavenging assays. Collectively, based on these data, is potential candidate, especially field cardiovascular pathology like atherosclerosis, thereby deserving in‐depth investigations.

Язык: Английский

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