In Vitro Culture of Human Dermal Fibroblasts on Novel Electrospun Polylactic Acid Fiber Scaffolds Loaded with Encapsulated Polyepicatechin Physical Gels DOI Creative Commons
Eliza Miranda-Buendía, Gertrudis Hortensia González-Gómez, Alfredo Maciel-Cerda

и другие.

Gels, Год журнала: 2024, Номер 10(9), С. 601 - 601

Опубликована: Сен. 20, 2024

Polyepicatechin (PEC) in a hydrogel has previously shown promise enhancing physiological properties and scaffold preparation. However, it remains unclear whether PEC-based fibers can be applied skin tissue engineering (STE). This study aimed to synthesize characterize electrospun PEC physical gels polylactic acid (PLA) scaffolds (PLAloadedPECsub) for potential use as constructs with human dermal fibroblasts (HDFs). was produced through enzymatic polymerization, confirmed by Fourier transform infrared (FTIR) spectroscopy. Scanning electron microscopy (SEM) demonstrated the feasibility of producing PLAloadedPECsub electrospinning. The metabolic activity viability HDFs cocultured indicate that is promising STE.

Язык: Английский

Rigid‐Flexible Coupled Dendritic Molecule Doping: General Approach to Activate Commercial Polymers into Harsh Condition‐Tolerant Multi‐Reusable Strong Supramolecular Adhesives DOI

Jie Feng,

Zi-Wei Lin, Yang Zhang

и другие.

Angewandte Chemie International Edition, Год журнала: 2024, Номер 63(45)

Опубликована: Июль 20, 2024

Abstract Developing functional adhesives combining strong adhesion, good recyclability and diverse harsh‐condition adaptability is a grand challenge. Here, we introduce general dendritic molecule doping strategy to activate commercial polymers into new family of supramolecular integrating high adhesion strength, ultralow temperature, water resistant multi‐reusable properties. Our method involves rational design rigid‐flexible coupled molecule—M 4 C 8 OH as versatile dopant, while simple M can modulate internal external non‐covalent interaction enable H‐bonding enhanced interchain cross‐linking for tough cohesion along with interphase interaction. This endows 20 wt % OH‐doped polycaprolactone (PCL) (PCL‐M OH) improved strength on various substrates the maximum increase up 2.87 times that PCL. In particular, strengths PCL‐M polymethyl methacrylate at 25 °C −196 reach 4.67 3.58 MPa—1.9 2.3 those PCL superior most reported adhesives. also displays markedly‐improved multi‐usability tolerance against temperature wet environments. Mechanism studies reveal crucial role molecular structures toward adhesion. be expanded other polymer matrices, yielding

Язык: Английский

Процитировано

5

Novel Biomaterials for Wound Healing and Tissue Regeneration DOI Creative Commons
Yi Zhong,

E.T. Wei,

Leran Wu

и другие.

ACS Omega, Год журнала: 2024, Номер unknown

Опубликована: Июль 16, 2024

Skin is the first defense barrier of human body, which can resist invasion external dust, microorganisms and other pollutants, ensure that body maintains homeostasis internal environment. Once skin damaged, health threat to will increase. Wound repair environment are a dynamic process. How effectively accelerate healing wounds without affecting guarantee repaired tissue retains its original function as much possible has become research hotspot. With advancement technology, researchers have combined new technologies develop prepare various types materials for wound healing. This article introduce developed prepared in recent years from three types: nanofibers, composite hydrogels, materials. The paper aims provide reference related fields multifunctional may be helpful design more ideal clinical application, then achieve better regeneration effects.

Язык: Английский

Процитировано

4

Fabricating Water‐Resistant and Stimuli Responsive Smart Hydrogels via Iminoboronate Chemistry DOI
Junfei Hu, Lin Li, Li Zhan

и другие.

Advanced Functional Materials, Год журнала: 2024, Номер unknown

Опубликована: Сен. 20, 2024

Abstract The construction and application of smart hydrogels often involve balancing the conflicting relationship between stability dynamics. Imine bond, as a type dynamic chemical bonding, is commonly used in diverse since it can effectively achieve response to some external stimuli. However, its poor thermodynamic leads limited crosslinking density easy degradation water biofluids. To address this critical issue, series model prepared with highly stimuli responsiveness via iminoboronate gelation aminoglycosides 8‐arm PEG terminated 2‐acetylphenylboronic acid pinacol ester [( pin )‐APBA]. Note that presence esters, electron‐donating agents hydrophobic couplers large steric hindrance, keep five‐membered ring intact protect nitrogen‐boron (N─B) coordination bond from molecules, offering resistance feature hydrogels. And rapid gels (e.g., acid, H 2 O unhindered amines) further confirmed their nature, allowing on‐demand release satisfactory antibacterial effect. This chemistry‐based strategy offer new opportunities toward stable various applications many fields.

Язык: Английский

Процитировано

4

Solvent-Free Partially Biobased Structural Adhesive with High Strength, Tolerance to Harsh Environments, and Multisubstrate Compatibility DOI
Shanshan Wu, Tongda Liu, Hongshan Li

и другие.

ACS Applied Polymer Materials, Год журнала: 2025, Номер unknown

Опубликована: Май 15, 2025

Язык: Английский

Процитировано

0

Transforming Commercial Polymers into Tough yet Switchable Adhesives by Trident Photoswitch Molecule Doping: Break Adhesion‐Switchability Paradox DOI Open Access
Zi-Wei Lin,

Jie Feng,

Long Fang

и другие.

Advanced Materials, Год журнала: 2024, Номер unknown

Опубликована: Авг. 9, 2024

Here, a trident molecule doping strategy is introduced to overcome both cohesion-adhesion trade-off and adhesion-switchability conflict, transforming commercial polymers into tough yet photo-switchable adhesives. The involves initial rational design of new photoswitch molecules namely TAzo-3 featuring azobenzene hydroxy-terminated alkyl chains involved rigid-soft tri-branch structure, subsequent polycaprolactone (PCL) via simple blending. Unique enables as versatile dopant, not only regulating the internal external supramolecular interaction balance cohesion interface adhesion for bonding, but also affording marked photothermal effect facilitate rapid adhesive melting great photo-switchability. Thus, optimal TAzo-3-doped PCL (TAzo-3@P) displays markedly-improved bonding performance on diverse substrates compared linear azobenzene-doped pure PCL. Impressively, TAzo-3@P polymethyl methacrylate (PMMA) attains large room-temperature strength 6.7 MPa - surpassing most reported adhesives many PMMA, along with easy photo-induced detachment remarkable switch ratio 2.09 × 10

Язык: Английский

Процитировано

3

Hyperbranched polyborate modified HTPB adhesives with enhanced performance and lower glass transition temperature DOI
Rui Wang, Xiao‐Ying Huang,

Kaiming Yang

и другие.

Polymer Chemistry, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

A simple hyperbranched polyborate was used to modify hydroxyl-terminated polybutadiene improve its low polarity and easy debonding. Reduce glass transition temperature have good mechanical properties at temperature.

Язык: Английский

Процитировано

2

Biogenic derived nanoparticles modulate mitochondrial function in cardiomyocytes DOI
Xiaolan Zheng, Tianyou Wang,

Jixing Gong

и другие.

Materials Horizons, Год журнала: 2024, Номер 11(20), С. 4998 - 5016

Опубликована: Янв. 1, 2024

PPP NPs revealed multiple functions with identified molecular mechanisms including ROS clearance and m6A modification regulation in alleviating damages presenting therapeutic roles mitochondrial sepsis-induced cardiomyopathy.

Язык: Английский

Процитировано

1

Rigid‐Flexible Coupled Dendritic Molecule Doping: General Approach to Activate Commercial Polymers into Harsh Condition‐Tolerant Multi‐Reusable Strong Supramolecular Adhesives DOI

Jie Feng,

Zi-Wei Lin, Yang Zhang

и другие.

Angewandte Chemie, Год журнала: 2024, Номер 136(45)

Опубликована: Июль 20, 2024

Abstract Developing functional adhesives combining strong adhesion, good recyclability and diverse harsh‐condition adaptability is a grand challenge. Here, we introduce general dendritic molecule doping strategy to activate commercial polymers into new family of supramolecular integrating high adhesion strength, ultralow temperature, water resistant multi‐reusable properties. Our method involves rational design rigid‐flexible coupled molecule—M 4 C 8 OH as versatile dopant, while simple M can modulate internal external non‐covalent interaction enable H‐bonding enhanced interchain cross‐linking for tough cohesion along with interphase interaction. This endows 20 wt % OH‐doped polycaprolactone (PCL) (PCL‐M OH) improved strength on various substrates the maximum increase up 2.87 times that PCL. In particular, strengths PCL‐M polymethyl methacrylate at 25 °C −196 reach 4.67 3.58 MPa—1.9 2.3 those PCL superior most reported adhesives. also displays markedly‐improved multi‐usability tolerance against temperature wet environments. Mechanism studies reveal crucial role molecular structures toward adhesion. be expanded other polymer matrices, yielding

Язык: Английский

Процитировано

0

In Vitro Culture of Human Dermal Fibroblasts on Novel Electrospun Polylactic Acid Fiber Scaffolds Loaded with Encapsulated Polyepicatechin Physical Gels DOI Creative Commons
Eliza Miranda-Buendía, Gertrudis Hortensia González-Gómez, Alfredo Maciel-Cerda

и другие.

Gels, Год журнала: 2024, Номер 10(9), С. 601 - 601

Опубликована: Сен. 20, 2024

Polyepicatechin (PEC) in a hydrogel has previously shown promise enhancing physiological properties and scaffold preparation. However, it remains unclear whether PEC-based fibers can be applied skin tissue engineering (STE). This study aimed to synthesize characterize electrospun PEC physical gels polylactic acid (PLA) scaffolds (PLAloadedPECsub) for potential use as constructs with human dermal fibroblasts (HDFs). was produced through enzymatic polymerization, confirmed by Fourier transform infrared (FTIR) spectroscopy. Scanning electron microscopy (SEM) demonstrated the feasibility of producing PLAloadedPECsub electrospinning. The metabolic activity viability HDFs cocultured indicate that is promising STE.

Язык: Английский

Процитировано

0