New Dawn in the Treatment of Rheumatoid Arthritis: Advanced Insight into Polymer Hydrogel Research DOI Creative Commons
Shuai Wang, Jinyang Li,

Fazhan Ren

и другие.

Gels, Год журнала: 2025, Номер 11(2), С. 136 - 136

Опубликована: Фев. 15, 2025

As a chronic systemic autoimmune disease, rheumatoid arthritis (RA) not only damages joints and other organs or systems throughout the body but also torments patients' physical mental health for long time, seriously affecting their quality of life. According to incomplete statistics at present, global prevalence RA is approximately 0.5-1%, number patients increasing year by year. Currently, drug therapies are usually adopted treatment RA, such as non-steroidal anti-inflammatory drugs (NSAIDs), disease-modifying antirheumatic (DMARDs), glucocorticoids/steroids, so on. However, traditional therapy has problems half-lives, cycles requiring frequent administration, lack specificity, possible adverse reactions (such gastrointestinal side effects, skin stratum corneum barrier damage, toxicity), which greatly restrict RA. In order improve limitations drug, physical, surgical treatments large related studies on have been carried out. Among them, hydrogels widely used in research due excellent biocompatibility, mechanical properties, general adaptability. For example, can be injected into synovial cavity fluid reduce wear between joints, lubricate avoid surface degradation. This article reviews applications under different functions situation carriers through delivery routes confirms outstanding potential great significance.

Язык: Английский

Nanoarchitectonics of a Skin‐Like Polymeric Hydrogel with High Anti‐Swelling and Self‐Adhesion Performance for Underwater Communication DOI Open Access
Yunjin Li,

Xinyi Lu,

Yihan Zhang

и другие.

Macromolecular Rapid Communications, Год журнала: 2025, Номер unknown

Опубликована: Янв. 15, 2025

Hydrogels are flexible materials characterized by a 3D network structure, which possess high water content and adjustable physicochemical properties. They have found widespread applications in tissue engineering, electronic skin, drug delivery, sensors, photothermal therapy. However, hydrogel networks often exhibit swelling behavior aqueous environments, can result structural degradation loss of gel performance. In this study, polyacrylic acid is utilized as the primary structure with incorporation natural polymer chitosan. Furthermore, conductive exhibiting good mechanical strength similar to human skin excellent anti-swelling properties developed integrating phytic into network. The as-prepared hydrogels exhibited maximum pure water, achieving an equilibrium rate 15%. Additionally, dopamine-grafted binder synthesized through coupling reaction enhance adhesion various substrates. demonstrated strong different Whether air or underwater, sensor effectively monitors movement behaviors. utilizing sensing signals send Morse code, facilitate underwater communication. This type anticipated play significant role wearable

Язык: Английский

Процитировано

0

New Dawn in the Treatment of Rheumatoid Arthritis: Advanced Insight into Polymer Hydrogel Research DOI Creative Commons
Shuai Wang, Jinyang Li,

Fazhan Ren

и другие.

Gels, Год журнала: 2025, Номер 11(2), С. 136 - 136

Опубликована: Фев. 15, 2025

As a chronic systemic autoimmune disease, rheumatoid arthritis (RA) not only damages joints and other organs or systems throughout the body but also torments patients' physical mental health for long time, seriously affecting their quality of life. According to incomplete statistics at present, global prevalence RA is approximately 0.5-1%, number patients increasing year by year. Currently, drug therapies are usually adopted treatment RA, such as non-steroidal anti-inflammatory drugs (NSAIDs), disease-modifying antirheumatic (DMARDs), glucocorticoids/steroids, so on. However, traditional therapy has problems half-lives, cycles requiring frequent administration, lack specificity, possible adverse reactions (such gastrointestinal side effects, skin stratum corneum barrier damage, toxicity), which greatly restrict RA. In order improve limitations drug, physical, surgical treatments large related studies on have been carried out. Among them, hydrogels widely used in research due excellent biocompatibility, mechanical properties, general adaptability. For example, can be injected into synovial cavity fluid reduce wear between joints, lubricate avoid surface degradation. This article reviews applications under different functions situation carriers through delivery routes confirms outstanding potential great significance.

Язык: Английский

Процитировано

0