Microneedle Arrays for Near-Infrared-Controlled Insulin Delivery Based on Thermosensitive Microgel DOI
Yunqian Dai,

Zhenxia Ma,

Zhuo Shi

и другие.

ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown

Опубликована: Май 29, 2025

Insulin delivery plays a crucial role in diabetic treatment. Regular painless administration methods are not ideal for insulin due to their insufficient bioavailability and inefficiency. In this study, dissolving microneedle array patches containing thermosensitive carrier P(NIPAm-AAm) microgel (MG) the photothermal agent MXene were prepared with drug-protected protocols near-infrared (NIR) light-controlled minimally invasive delivery. The microneedles (Ins-MG/MXene-HA-MNs) can penetrate stratum corneum, rapidly heat above 42 °C 10 s, promote release of an instant response NIR light exposure. vitro vivo experiments showed that Ins-MG/MXene-HA-MNs biocompatible efficient. Using one patch two brief exposures ensure effective blood levels maintain normoglycemia rats over 6 h at high glucose levels. Additionally, fabrication application drug system have been designed protect bioactivity. results MG/MXene-HA-MN realized NIR-controlled multiple on-demand dosing, highlighting its potential routine management.

Язык: Английский

Microneedle Arrays for Near-Infrared-Controlled Insulin Delivery Based on Thermosensitive Microgel DOI
Yunqian Dai,

Zhenxia Ma,

Zhuo Shi

и другие.

ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown

Опубликована: Май 29, 2025

Insulin delivery plays a crucial role in diabetic treatment. Regular painless administration methods are not ideal for insulin due to their insufficient bioavailability and inefficiency. In this study, dissolving microneedle array patches containing thermosensitive carrier P(NIPAm-AAm) microgel (MG) the photothermal agent MXene were prepared with drug-protected protocols near-infrared (NIR) light-controlled minimally invasive delivery. The microneedles (Ins-MG/MXene-HA-MNs) can penetrate stratum corneum, rapidly heat above 42 °C 10 s, promote release of an instant response NIR light exposure. vitro vivo experiments showed that Ins-MG/MXene-HA-MNs biocompatible efficient. Using one patch two brief exposures ensure effective blood levels maintain normoglycemia rats over 6 h at high glucose levels. Additionally, fabrication application drug system have been designed protect bioactivity. results MG/MXene-HA-MN realized NIR-controlled multiple on-demand dosing, highlighting its potential routine management.

Язык: Английский

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