Cited by Zein and 3-Aminophenyl Boronic Acid Conjugated Polyvinylpyrrolidone Polymer Blend: Electrospinning, Characterization, and Mucoadhesive Drug Delivery

Zein and 3-Aminophenyl Boronic Acid Conjugated Polyvinylpyrrolidone Polymer Blend: Electrospinning, Characterization, and Mucoadhesive Drug Delivery DOI

и другие.

ACS Applied Bio Materials, Год журнала: 2024, Номер 7(11), С. 7429 - 7443

Опубликована: Окт. 18, 2024

The era of mucoadhesive polymers has advanced to the next generation, focusing on targeted adhesion chemical functional groups with mucosa. This work aims develop boronic acid functionalized polymers, which could facilitate reversible binding mucin in Pendant were conjugated chains polyvinylpyrrolidone (PVP) via C═N bonding. evidence from FTIR spectroscopy, XPS analysis, and UV spectroscopy been used for confirmation conjugation 3-aminophenyl (APBA) PVP. Boronate ester formation is a pH-dependent process. High pKa values APBA preferably cause trigonal-shaped sialic mucin. Boronic moieties additionally benefited mucoadhesion comparison PVP alone, result five-membered boronate complex. presence enhanced force porcine buccal mucosal tissue 13.12 ± 1.52 19.04 1.97 g force. Specific polymer surface caused prolonged surface. A blend zein explored its potential delivery propranolol hydrochloride.

Язык: Английский

Interpenetrating Polymer Networks in Biomedical Fields: Recent Advanced and Applications DOI

Farangis Shahi,

Sara Zarei,

Razhan Salah Othman

и другие.

Polymers for Advanced Technologies, Год журнала: 2025, Номер 36(2)

Опубликована: Фев. 1, 2025

ABSTRACT Recent developments in polymer materials have led to an increased implementation of hydrogels biomedical settings, especially the creation smart hydrogels. Traditional single‐network often exhibit challenges, such as poor mechanical strength, insufficient biocompatibility, and slow response rates. To address these issues, researchers introduced Interpenetrating Polymer Network (IPN) hydrogels, which significantly improve strength via topological entanglements physical interactions. This dual‐network design not only enhances biocompatibility but also responsiveness stimuli, endowing with distinctive properties like cell adhesion, conductivity, hemostatic functions, antioxidant abilities, color‐changing properties. The purpose this article is elucidate factors that trigger stimuli IPN their impacts on cellular behavior, various applications they can serve. A comprehensive overview provided regarding classification, mechanisms, performance attributes, related subjects. Ultimately, review emphasizes promise hold fulfilling increasing need for innovative improved features sector.

Язык: Английский

Процитировано

Tailoring the dendronized structures of cyclodextrin-based supramolecular nanoassemblies for enhanced tumor paraptosis via disrupting endoplasmic reticulum homeostasis DOI