Mechanistic Study of Cancer Drug Delivery: Current Techniques, Limitations, and Future Prospects DOI Creative Commons

Saiqa Imtiaz,

Umme Tamanna Ferdous,

Alexis Nizela

и другие.

European Journal of Medicinal Chemistry, Год журнала: 2025, Номер 290, С. 117535 - 117535

Опубликована: Март 20, 2025

Cancer drug delivery remains a critical challenge with systemic toxicity, poor bioavailability, and lack of effective targeting. Overcoming these barriers is essential for improving treatment efficacy patient outcomes. This review discusses current techniques that reshape cancer therapy by offering precise, controlled-release tailored to tumor-specific features. Innovations in nanotechnology, immunotherapy, gene enable interventions at molecular cellular levels. Radiomics pathomics integrate high-dimensional data optimize diagnostics planning. Combination addresses the complexities tumor heterogeneity synergizing multiple agents within single therapeutic framework, while peptide-drug conjugates enhance specificity potency. Hydrogel-based systems microneedle arrays offer localized, sustained release, significantly However, clinical translation advancements faces significant such as resistance, off-target effects, scalability, cost, ethical concerns. Moreover, regulatory economic feasibility therapies highlight need innovative frameworks make them accessible globally. Therefore, there innovation cell therapy, next-generation platforms, personalized medicine. focuses on recent over past decade, evaluating their limitations exploring potential future directions transforming treatment.

Язык: Английский

Mechanistic Study of Cancer Drug Delivery: Current Techniques, Limitations, and Future Prospects DOI Creative Commons

Saiqa Imtiaz,

Umme Tamanna Ferdous,

Alexis Nizela

и другие.

European Journal of Medicinal Chemistry, Год журнала: 2025, Номер 290, С. 117535 - 117535

Опубликована: Март 20, 2025

Cancer drug delivery remains a critical challenge with systemic toxicity, poor bioavailability, and lack of effective targeting. Overcoming these barriers is essential for improving treatment efficacy patient outcomes. This review discusses current techniques that reshape cancer therapy by offering precise, controlled-release tailored to tumor-specific features. Innovations in nanotechnology, immunotherapy, gene enable interventions at molecular cellular levels. Radiomics pathomics integrate high-dimensional data optimize diagnostics planning. Combination addresses the complexities tumor heterogeneity synergizing multiple agents within single therapeutic framework, while peptide-drug conjugates enhance specificity potency. Hydrogel-based systems microneedle arrays offer localized, sustained release, significantly However, clinical translation advancements faces significant such as resistance, off-target effects, scalability, cost, ethical concerns. Moreover, regulatory economic feasibility therapies highlight need innovative frameworks make them accessible globally. Therefore, there innovation cell therapy, next-generation platforms, personalized medicine. focuses on recent over past decade, evaluating their limitations exploring potential future directions transforming treatment.

Язык: Английский

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