Clinical and Experimental Optometry,
Год журнала:
2025,
Номер
unknown, С. 1 - 7
Опубликована: Фев. 12, 2025
Glaucoma
is
a
multifactorial
neurodegenerative
disorder
characterised
by
the
progressive
loss
of
retinal
ganglion
cells,
ultimately
leading
to
irreversible
blindness
worldwide.
Recent
research
highlights
metabolic
dysregulation
as
crucial
factor
in
pathophysiology
glaucoma.
This
review
examines
intricate
relationship
between
processes
and
glaucoma,
with
focus
on
key
mechanisms
such
mitochondrial
dysfunction,
lipid
metabolism,
glucose
roles
specific
metabolites.
Mitochondrial
dysfunction
commonly
observed
impaired
energy
production
that
compromises
cellular
viability.
Alterations
including
changes
fatty
acid
profiles
peroxidation,
contribute
injury
apoptosis
cells.
Moreover,
disturbances
reduced
glycolytic
activity,
affect
availability
neurotrophic
support
are
vital
for
cells
survival.
The
also
explores
metabolites,
lactate
glutamate,
context
health,
how
their
may
exacerbate
glaucomatous
damage.
Additionally,
interplay
elevated
intraocular
pressure
analysed,
particularly
regard
its
impact
ocular
blood
flow
health.
Understanding
these
essential
identifying
potential
therapeutic
strategies.
By
deepening
our
understanding
foundations
new
avenues
effective
treatments
arise,
addressing
nature
this
complex
disease
improving
patient
outcomes.
Cells,
Год журнала:
2023,
Номер
12(15), С. 1969 - 1969
Опубликована: Июль 30, 2023
This
review
aims
to
provide
a
better
understanding
of
the
emerging
role
mitophagy
in
glaucomatous
neurodegeneration,
which
is
primary
cause
irreversible
blindness
worldwide.
Increasing
evidence
from
genetic
and
other
experimental
studies
suggests
that
mitophagy-related
genes
are
implicated
pathogenesis
glaucoma
various
populations.
The
association
between
polymorphisms
these
increased
risk
presented.
Reduction
intraocular
pressure
(IOP)
currently
only
modifiable
factor
for
glaucoma,
while
clinical
trials
highlight
inadequacy
IOP-lowering
therapeutic
approaches
prevent
sight
loss
many
patients.
Mitochondrial
dysfunction
thought
increase
susceptibility
retinal
ganglion
cells
(RGCs)
factors
degeneration.
Mitophagy
holds
vital
mitochondrial
quality
control
processes,
current
explores
pathways
may
be
linked
their
potential.
iScience,
Год журнала:
2024,
Номер
27(7), С. 110309 - 110309
Опубликована: Июнь 20, 2024
Mitochondrial
dysfunction
and
Müller
cells
gliosis
are
significant
pathological
characteristics
of
retinal
degeneration
(RD)
causing
blinding.
Stem
cell
therapy
is
a
promising
treatment
for
RD,
the
recently
accepted
therapeutic
mechanism
fusion
induced
materials
transfer.
However,
whether
including
mitochondrial
transfer
between
grafted
stem
recipient's
contribute
to
suppressing
unclear.
In
present
study,
we
demonstrated
that
bone
marrow
mesenchymal
(BMSCs)
transferred
mitochondria
by
tunneling
nanotubes.
BMSCs-derived
(BMSCs-mito)
were
integrated
into
network
cells,
improving
function,
reducing
oxidative
stress
gliosis,
which
protected
visual
function
partially
in
degenerative
rat
retina.
RNA
sequencing
analysis
revealed
BMSCs-mito
increased
DNA
(mtDNA)
content
facilitated
damaged
cells.
It
suggests
from
BMSCs
remodels
metabolism
suppresses
gliosis;
thus,
delaying
progression
RD.
Clinical and Experimental Optometry,
Год журнала:
2025,
Номер
unknown, С. 1 - 7
Опубликована: Фев. 12, 2025
Glaucoma
is
a
multifactorial
neurodegenerative
disorder
characterised
by
the
progressive
loss
of
retinal
ganglion
cells,
ultimately
leading
to
irreversible
blindness
worldwide.
Recent
research
highlights
metabolic
dysregulation
as
crucial
factor
in
pathophysiology
glaucoma.
This
review
examines
intricate
relationship
between
processes
and
glaucoma,
with
focus
on
key
mechanisms
such
mitochondrial
dysfunction,
lipid
metabolism,
glucose
roles
specific
metabolites.
Mitochondrial
dysfunction
commonly
observed
impaired
energy
production
that
compromises
cellular
viability.
Alterations
including
changes
fatty
acid
profiles
peroxidation,
contribute
injury
apoptosis
cells.
Moreover,
disturbances
reduced
glycolytic
activity,
affect
availability
neurotrophic
support
are
vital
for
cells
survival.
The
also
explores
metabolites,
lactate
glutamate,
context
health,
how
their
may
exacerbate
glaucomatous
damage.
Additionally,
interplay
elevated
intraocular
pressure
analysed,
particularly
regard
its
impact
ocular
blood
flow
health.
Understanding
these
essential
identifying
potential
therapeutic
strategies.
By
deepening
our
understanding
foundations
new
avenues
effective
treatments
arise,
addressing
nature
this
complex
disease
improving
patient
outcomes.
