Acta Ophthalmologica, Год журнала: 2024, Номер unknown
Опубликована: Дек. 24, 2024
To evaluate the long-term effects of implantable collamer lens (ICL) V4c on biomechanical and morphological properties crystalline lenses in Chinese adults with high myopia using Brillouin microscopy (BM).
Язык: Английский
Progress in Retinal and Eye Research, Год журнала: 2024, Номер 103, С. 101291 - 101291
Опубликована: Авг. 25, 2024
Язык: Английский
Процитировано
8
Investigative Ophthalmology & Visual Science, Год журнала: 2025, Номер 66(1), С. 2 - 2
Опубликована: Янв. 2, 2025
Purpose: To investigate the 10-year changes in visual function and incidence of impairment (VI) highly myopic eyes. Methods: This longitudinal study enrolled individuals who were followed up for 10 years. All participants underwent detailed ophthalmic examinations at baseline follow-up visits. Best-corrected acuity (BCVA) was measured using Early Treatment Diabetic Retinopathy Study protocol, field (VF) assessed with standard automatic perimetry. Results: A total 568 eyes (284 participants) included, mean age 22.49 ± 13.07 years, spherical equivalent refraction (SER) −9.72 3.02 D, axial length 27.39 1.53 mm. Over BCVA loss −0.06 logMAR (95% confidence internal [CI], 0.05−0.07). The change rates deviation (MD) pattern over time −0.07 dB/y CI, −0.08 to −0.06) 0.036 0.028 0.044), respectively. monocular moderate severe VI (MSVI), per World Health Organization (WHO) US criteria, 3.52% 2.16%–5.39%) 6.35% 4.46%–8.72%). Higher MSVI incidence, defined by WHO associated more SER lower MD. Additionally, higher US-defined correlated worse BCVA. Conclusions: In a population, both VF deteriorated time, increasing incidence. Raising public awareness vision risks linked high myopia implementing strategies reduce burden high-risk are essential.
Язык: Английский
Процитировано
0
Ophthalmology Science, Год журнала: 2025, Номер 5(3), С. 100705 - 100705
Опубликована: Янв. 8, 2025
To investigate the association between spherical equivalent refraction (SER) and pallor in different neuroretinal rim (NRR) sectors. Population-based cross-sectional study. Normal eyes of 24 057 healthy participants aged 40 to 70 years from UK Biobank. Pallor NRR sectors was quantitatively derived color fundus photographs using automated software. We first examined SER each sector-controlling for age, sex, ethnicity (White vs. non-White), intraocular pressure, mean blood pressure. then incorporated disc-fovea distance (the shortest center disc fovea) temporal arterial/venous concavity (extent which artery/vein curved inwardly toward as additional independent variables, these features have been suggested reflect degree axonal stretching at posterior pole. temporal, inferior, nasal nasal, superior, superior NRR. Moving sector sector, varied an asymmetrical U-shaped pattern, with least observed nasally. White tended paler NRR, but did not differ ethnic groups (no interaction effect ethnicity). Decreasing associated increasing all 6 (all P < 0.001), (ß: -0.009, 95% confidence interval: -0.011 -0.008) inferior -0.008, -0.009 -0.007) exhibited steepest increase. The rate increase diminished by half more nasal/central sectors, another nasal-most sector. Consistent changes, resulted up 4 times much temporally compared These retinal changes accounted approximately ≥50% on pallor. increases faster than is primarily attributable concavity. findings suggest that papillomacular nerve fiber bundle, linked most susceptible myopic stretching. author(s) no proprietary or commercial interest any materials discussed this article.
Язык: Английский
Процитировано
0
Translational Vision Science & Technology, Год журнала: 2025, Номер 14(1), С. 18 - 18
Опубликована: Янв. 17, 2025
Purpose: The purpose of this study was to evaluate the correlation between axial length (AL) and retinal oxygen dynamic parameters in adult patients. Methods: This an observational cross-sectional with 79 Chinese adults myopia aged 18 37 years. All participants underwent AL measurements, cycloplegic refraction, other ophthalmic examinations. Additionally, kinetics imaging analysis (ROKIA) system utilized obtain all Simple multiple linear regression tests were used assess various AL. Results: mean age, AL, spherical equivalent (SE) subjects 26.32 ± 5.4 years, 25.78 1.06 mm, −5.13 2.1 diopters (D), respectively. Pearson coefficients among delivery (DO2) metabolism (MO2) −0.44 (95% confidence interval = −0.24 −0.60, P < 0.001), −0.26 −0.04 −0.46, 0.02), group high exhibited lower DO2 higher extraction fraction (OEF) compared moderate myopia, no significant difference observed MO2 two groups. In multivariate analyses adjusting for sex, intraocular pressure (IOP), anterior chamber depth (ACD), a longer significantly associated decreased (standardized coefficient B −0.47, 0.001). Conclusions: Retinal parameters, including MO2, myopic eyes. Patients demonstrated elevated OEF than those myopia. Translational Relevance: that changes as confirmed using novel device quantifies provides new monitoring approach hypoxic diseases.
Язык: Английский
Процитировано
0
Photodiagnosis and Photodynamic Therapy, Год журнала: 2025, Номер unknown, С. 104519 - 104519
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0
PeerJ, Год журнала: 2025, Номер 13, С. e19030 - e19030
Опубликована: Март 5, 2025
Changes in retinal and choroidal structures are key biomarkers for predicting, diagnosing, monitoring various ocular conditions, including myopia. To assess the characteristics of thicknesses myopic young adult males using swept-source optical coherence tomography (SSOCT). This cross-sectional comparative study included 198 adults with a mean age 21.87 ± 1.69 years, only male subjects were recruited this study, comprising 102 diagnosed myopia 96 emmetropia. Refraction was assessed an autorefractometer, comprehensive SSOCT scans conducted to measure thickness retina choroid at nine predefined locations. Data analysis focused on identifying significant patterns correlations between thickness. Myopic -2.66 1.59D exhibited significantly decreased compared emmetropic 0.18 0.39D, (p < 0.01). Similarly, their also thinner The findings showed weak but statistically inverse correlation spherical equivalent (r = -0.257, p Correspondingly, stronger observed -0.306, Choroidal all studied areas degree 0.05), except superior outer region, where association not 0.056). identified differences individuals. use effectively detected these morphological changes adults, offering valuable insights into myopia's pathophysiology potentially guiding targeted therapeutic strategies control.
Язык: Английский
Процитировано
0
Investigative Ophthalmology & Visual Science, Год журнала: 2025, Номер 66(4), С. 5 - 5
Опубликована: Апрель 1, 2025
To investigate the prevalence and risk factors of enlarged blind spots in non-pathological highly myopic eyes. Visual field conditions 313 eyes 172 individuals with high myopia were evaluated. Clinical characteristics 116 normal visual fields compared. Generalized-estimating equation (GEE) regression model used to assess associated spots. The frequency was 37.06% this sample. Eyes had larger gamma zone (P = 0.038), PHOMS area < 0.001), increased peripapillary retinal nerve fiber layer thickness 0.006), decreased macular ganglion cell-inner plexiform 0.016) compared fields. In multivariate analysis, an expanded (OR 2.004; P 0.022) a 4.414; 0.009) spot. An are spot, indicating that these two parameters may suggest possibility functional damage early nonpathological, This pattern impairment might provide clues for differential diagnosis between glaucoma.
Язык: Английский
Процитировано
0
Cell Biology and Toxicology, Год журнала: 2025, Номер 41(1)
Опубликована: Апрель 2, 2025
Sodium fluoride-induced ocular damage constitutes a significant public health concern globally; however, the precise molecular mechanisms underlying this issue remain obscure. This study aims to investigate effects of sodium fluoride on myopia and offer novel theoretical foundations for future strategies in prevention control. The experimental data showed that could promote progression, through bioinformatics analysis, we found affect ferroptosis pathway. Western blotting redox kit assays further confirmed activates We also demonstrated PIEZO1 plays crucial role myopia, inhibitor (GsMTx4) can inhibit Subsequently, identified as potential target baicalin, which inhibited expression vivo vitro, by docking modeling CETSA assays. Finally, baicalin via PIEZO1. Taken together, our findings indicate progression activating pathway PIEZO1, targeting delay may provide new drug treatment future.
Язык: Английский
Процитировано
0
Advances in Clinical Medicine, Год журнала: 2025, Номер 15(04), С. 967 - 973
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Scientific Reports, Год журнала: 2025, Номер 15(1)
Опубликована: Апрель 14, 2025
To evaluate the effectiveness of integrated people-centered eye car"365 Eye Care," in controlling myopia among children and adolescents northeast China. Additionally, study aimed to explore model's impact on different subgroups. A retrospective analysis was conducted changes spherical equivalent(∆SE) within one year 427 participants 494 control who underwent "365 Care"project at He Specialist Hospital from January 2021 December 2023. The Care"on vision protection analyzed. difference between two groups further analyzed when baseline SE constant. project included causes formulation individualized prevention plans, monthly examination visual status monitoring, assessing environment (including diet, light, table chair selection, etc.) 1-year change SE(∆SE) - 0.46 ± 0.36 for eyecare" group and- 1.82 1.14 (P < 0.001). pre-myopia, low myopia, moderate were significantly lower than group(P 0.001), 1.25D, 1.38D, 0.81D, respectively. There no high myopia. results showed that comprehensive care intervention helped slow down progression average effect level 0.71. model, eyecare," holds promise control. And earlier participated intervention, better effect.
Язык: Английский
Процитировано
0