Elsevier eBooks, Год журнала: 2024, Номер unknown, С. 439 - 461
Опубликована: Янв. 1, 2024
Язык: Английский
Ageing Research Reviews, Год журнала: 2023, Номер 88, С. 101960 - 101960
Опубликована: Май 22, 2023
Язык: Английский
Процитировано
51
European Journal of Medicinal Chemistry Reports, Год журнала: 2024, Номер 11, С. 100154 - 100154
Опубликована: Апрель 7, 2024
Alzheimer's disease (AD), the main dementia type accounting for over 70 % of entire population, progressive decline in memory and executive function. AD pathology is characterized by amyloid fibrils neurofibrillary tangles. Acetylcholinesterase (AChE), an enzyme involved hydrolysis neurotransmitter acetylcholine, consistently colocalizes with deposits characteristic may contribute to generation proteins. AChE a potent amyloid-promoting factor when compared other c-associated inhibitors play vital role prevent formation toxic oligomeric form peptide. Recent studies have reported that acetylcholinesterase (ChE-Is) are present plants, fungi, marine products. Some cholinesterase inhibitors, obtained from plant source such as rivastigmine, donepezil, galantamine, used treatment AD, offer alternative approach alleviate its symptoms reducing Aβ. Due limited efficacy current drugs there huge potential phytomedicines AD. Medicinal herbs herbal drug preparations traditionally been treat neurological disorders exhibiting anti-inflammatory neuroprotective properties. Phytomedicines containing flavonoids, polyphenols, naturally occurring antioxidants crosses blood-brain barrier protect neurons oxidative stress. As synthetic drugs, fewer side effects. Therefore, recent research focused explore develop it effective In our review, we summarized amyloid-deposition, Acetylcholinesterase, phytoconstituents inhibitory activity treatment.
Язык: Английский
Процитировано
22
Biomedicine & Pharmacotherapy, Год журнала: 2022, Номер 147, С. 112647 - 112647
Опубликована: Фев. 8, 2022
Protein misfolding causes aggregation and build-up in a variety of brain diseases. There are numeral molecules that linked with the protein homeostasis mechanism. Molecular chaperones one such responsible for protection against misfolded aggregation-induced neurotoxicity. Many studies have explored participation molecular Parkinson's disease, Alzheimer's Amyotrophic lateral sclerosis, Huntington's In this review, we highlighted constructive role neurological diseases characterized by their capability to control aberrant interactions at an early stage thus successfully suppressing pathogenic cascades. A comprehensive understanding associated basis involvement chaperone cellular stress might lead progress new therapeutic intrusion-related aggregation.
Язык: Английский
Процитировано
40
Deleted Journal, Год журнала: 2024, Номер 6(5)
Опубликована: Апрель 16, 2024
Abstract Alzheimer’s disease (AD) is a progressive neurodegenerative disorder primarily associated with aging. This devastating condition characterized by significant memory loss, abnormal behavior, personality shifts, and decline in cognitive function. Despite extensive research, no cure for currently exists, available treatment options have shown limited effectiveness. Developing therapeutic interventions to slow down or prevent the onset progression of crucial address growing burden this condition. Ayurvedic medicinal herbs emerged as promising avenue drug numerous compounds derived from these undergoing clinical trials. Scientific studies explored potential application various plants their derivatives disease. Although precise mechanisms action remain largely unknown, phytochemical investigations identified wide range beneficial within plants. These include lignans, flavonoids, tannins, polyphenols, triterpenes, sterols, alkaloids, each exhibiting diverse pharmacological activities. activities encompass anti-inflammatory, anti-amyloidogenic, anticholinesterase, hypolipidemic, antioxidant effects. review highlights phytochemistry ethnomedicinal applications plants, along bioactive compounds. It underscores Ayurveda, one world’s oldest holistic healing systems, identifying effective disorders like The constituents suggest novel treatments findings offer hope addressing challenges posed debilitating Graphical
Язык: Английский
Процитировано
12
Pharmaceutical Nanotechnology, Год журнала: 2024, Номер 13(1), С. 70 - 89
Опубликована: Янв. 26, 2024
Phytopharmaceuticals, derived from natural sources, manifest tremendous potential for therapeutic applications. Nevertheless, effective delivery of these bio-actives presents significant challenges. A breakthrough in fortifying phytopharmaceuticals within phosphatidylcholine is a promising remedy to overcome solubility, permeability, and other related drawbacks. This intrinsic lipid, which obtained both synthetic confers numerous benefits, encompassing heightened augmented bioavailability, enhanced stability. The conjugation with enables improved dermal permeation, absorption, targeted distribution, the possibility synergistic results, eventually improving efficacy. Additionally, use enriched route overcoming limitations imposed by conventional techniques, encouraging more treatments. review provides thorough analysis phosphatidylcholine- incorporated as nanomedicine variables that significantly affect their Moreover, elaborates on how improves tissue distribution boosts phytopharmaceuticals. Further, underscores significance nano-formulation strategies, analytical methodologies, forthcoming prospects propel this field forward. Furthermore, emphasizes inherent innovative approach while highlighting importance additional research endeavors collaborative initiatives unlock benefits phosphatidylcholinefortified phytopharmaceuticals, enhancing patient well-being.
Язык: Английский
Процитировано
10
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(14), С. 7530 - 7530
Опубликована: Июль 9, 2024
Aging is a multifaceted process influenced by hereditary factors, lifestyle, and environmental elements. As time progresses, the human body experiences degenerative changes in major functions. The external internal signs of aging manifest various ways, including skin dryness, wrinkles, musculoskeletal disorders, cardiovascular diseases, diabetes, neurodegenerative cancer. Additionally, cancer, like aging, complex disease that arises from accumulation genetic epigenetic alterations. Circadian clock dysregulation has recently been identified as an important risk factor for cancer development. Natural compounds herbal medicines have gained significant attention their potential preventing age-related diseases inhibiting progression. These demonstrate antioxidant, anti-inflammatory, anti-proliferative, pro-apoptotic, anti-metastatic, anti-angiogenic effects well circadian regulation. This review explores cancers, specific natural targeting key features these conditions.
Язык: Английский
Процитировано
8
European Journal of Clinical Pharmacology, Год журнала: 2022, Номер 78(10), С. 1567 - 1587
Опубликована: Июль 26, 2022
Язык: Английский
Процитировано
36
Future Pharmacology, Год журнала: 2023, Номер 3(4), С. 877 - 907
Опубликована: Ноя. 13, 2023
Alzheimer’s disease (AD) is a progressive, multifactorial, and unremitting neurodegenerative characterized by memory loss, personality changes, cognitive impairment. It has become more prevalent in recent years. Therefore, understanding the pathophysiology of AD developing efficient therapeutic strategies are essential. Moreover, progression unaffected pharmaceutical approaches discovered to date. Additionally, failure over 200 potential drug candidates clinical trials past decade suggests complexity difficulty both its underlying causes. research focused on medicinal plant-based natural products search for novel neuroprotective Indeed, several scientific investigations have demonstrated efficacy many plants their principal phytochemicals treatment AD. This review article covered pathophysiological mechanisms AD, necessity as anti-AD treatments, most preclinical studies revealing function bioactive compounds effective management In addition, also presents trial data promising formulations/agents plant origin. Revealing findings highlighting related development new treatments would promote further this field pave way safe debilitating disease.
Язык: Английский
Процитировано
19
Ageing Research Reviews, Год журнала: 2024, Номер 96, С. 102269 - 102269
Опубликована: Март 11, 2024
Язык: Английский
Процитировано
7
European Journal of Neuroscience, Год журнала: 2024, Номер 60(1), С. 3466 - 3490
Опубликована: Май 10, 2024
Abstract In females, Alzheimer's disease (AD) incidences increases as compared to males due estrogen deficiency after menopause. Estrogen therapy is the mainstay for menopause and associated complications. Estrogen, a hormone with multifaceted physiological functions, has been implicated in AD pathophysiology. plays crucial role amyloid precursor protein (APP) processing overall neuronal health by regulating various factors such brain‐derived neurotrophic factor (BDNF), intracellular calcium signalling, death domain‐associated (Daxx) translocation, glutamatergic excitotoxicity, Voltage‐Dependent Anion Channel, Insulin‐Like Growth Factor 1 Receptor, estrogen‐metabolising enzymes apolipoprotein E (ApoE) polymorphisms. All these impact physiology of postmenopausal women. replacement therapies play an important treatment strategy prevent However, use may lead increased risks breast cancer, venous thromboembolism cardiovascular disease. Various therapeutic approaches have used mitigate effects on AD. These include therapy, Selective Receptor Modulators (SERMs), Beta (ERβ)‐Selective Agonists, Transdermal Delivery, Localised Combination Therapies, Metabolism Modulation Alternative Estrogenic Compounds like genistein from soy, notable phytoestrogen plant sources. mechanism via which modulate women not explained earlier thoroughly. Present review will enlighten all molecular mechanisms Along‐with this, association between estrogen, ApoE polymorphisms also be discussed
Язык: Английский
Процитировано
6