Pandanus amaryllifolius Exhibits In Vitro Anti-Amyloidogenic Activity and Promotes Neuroprotective Effects in Amyloid-β-Induced SH-SY5Y Cells

Nutrients, Год журнала: 2022, Номер 14(19), С. 3962 - 3962

Опубликована: Сен. 24, 2022

Accumulation of amyloid-beta (Aβ) plaques leading to oxidative stress, mitochondrial damage, and cell death is one the most accepted pathological hallmarks Alzheimer's disease (AD). Pandanus amaryllifolius, commonly recognized as fragrant screw pine due its characteristic smell, widely distributed in Southeast Asia consumed a food flavor. In search for potential anti-AD agents from terrestrial sources, P. amaryllifolius was explored vitro anti-amyloidogenic neuroprotective effects. Thioflavin T (ThT) assay high-throughput screening multimer detection system (MDS-HTS) were used evaluate extracts' inhibit Aβ aggregations oligomerizations, respectively. The crude alcoholic extract (CAE, 50 μg/mL) base (CBE, obstructed aggregation. Interestingly, results revealed that only CBE inhibited nucleation at 100 μg/mL. Both CAE also restored viability, reduced level reactive oxygen species, reversed dysfunctions 10 20 μg/mL concentrations Aβ-insulted SY-SY5Y cells. addition, unprecedented isolation nicotinamide remarkable discovery bioactive constituents against AD. Hence, our provided new insights into promising extracts AD further exploration other prospective constituents.

Язык: Английский

---

Digital Intervention for the Management of Alzheimer’s Disease

Current Alzheimer Research, Год журнала: 2022, Номер 19(14), С. 909 - 932

Опубликована: Дек. 1, 2022

Abstract: Alzheimer’s disease (AD) is a progressive, multifactorial, chronic, neurodegenerative with high prevalence and limited therapeutic options, making it global health crisis. Being the most common cause of dementia, AD erodes cognitive, functional, social abilities individual causes escalating medical psychosocial needs. As yet, this disorder has no cure current treatment options are palliative in nature. There an urgent need for novel therapy to address pressing challenge. Digital therapeutics (Dtx) one such that gaining popularity globally. Dtx provides evidence based interventions driven by internet software, employing tools as mobile devices, computers, videogames, apps, sensors, virtual reality aiding prevention, management, ailments like neurological abnormalities chronic diseases. acts supportive tool optimization patient care, individualized improved outcomes. uses visual, sound other non-invasive approaches instance-consistent therapy, reminiscence computerised cognitive training, semantic phonological assistance wearables computer-assisted rehabilitation environment find applications Alzheimer's improving memory, cognition, functional managing motor symptom. A few Dtx-based employed include "Memory Matters", "AlzSense", "Alzheimer Assistant", "smart robotic dog", "Immersive (iVR)" gamma stimulation. The purpose review summarize trends digital explore benefits, challenges, impediments using adjunctive management AD.

Язык: Английский

---

Phytochemical screening, antioxidant analyses, and in vitro and in vivo antimalarial activities of herbal medicinal plant - Rotheca serrata (L.) Steane & Mabb.

Journal of Ethnopharmacology, Год журнала: 2023, Номер 321, С. 117466 - 117466

Опубликована: Ноя. 21, 2023

Язык: Английский

---

Effects of long-term Ailanthus altissima extract supplementation on fear, cognition and brain antioxidant levels

Saudi Pharmaceutical Journal, Год журнала: 2022, Номер 31(2), С. 191 - 206

Опубликована: Дек. 15, 2022

Ailanthus altissima is an indigenous plant known for various remedial properties. The present study aimed to evaluate the neuroprotective potential of methanolic extract (AA) bark as current scientific trend searching neurodegenerative diseases, worldwide.In in-vitro experiments, AA was analyzed phenols, flavonoids, antioxidative and cholinesterase inhibitory properties with subsequent detailed characterization secondary metabolites. in-vivo neurological effects were evaluated in rats through behavioral assessment anxiety memory after chronic administration (28 days) 50-200 mg/kg AA. At end behavior studies, isolated brains biochemically tested determine antioxidant enzyme activity.AA found rich phenols/flavonoids active radical scavenging presence 13 metabolites UHPLC-MS analysis. yielded anxiolytic dose-dependently open field, light/dark elevated-plus maze tests animals significantly (P < 0.05 vs control group) preferred arena, illuminated zone exposed arms maze. Similarly, treated showed significant amnesic increase spontaneous alternation, discrimination index y-maze, novel object recognition tests. Further, AA.Cr noticeably shorter escape latencies Morris water tests.In biochemical analysis, dissected reduced levels AChE malondialdehyde increased first-line enzymes i.e. glutathione peroxidase superoxide dismutase. These observed biological might be attributed phenols flavonoids constituents owned by -The in-silico studies thatconessine lophirone J phytocompounds have good blood-brain barrier permeability interaction AChE.The outcomes this validate that work a source bioactive phytochemicals potential.

Язык: Английский

---

Combinatorial therapy in Alzheimer's disease

Elsevier eBooks, Год журнала: 2024, Номер unknown, С. 439 - 461

Опубликована: Янв. 1, 2024

Язык: Английский

---