Synergistic Effect of Donepezil and Neurotropic B Vitamins on Dysregulated Antioxidant, Inflammation and Neurotransmitter Status in Aluminium Chloride‐Induced Neurotoxicity in Rats DOI
Bidemi Emmanuel Ekundayo, Olusola Bolaji Adewale, Blessing A. Afolabi

и другие.

Cell Biochemistry and Function, Год журнала: 2024, Номер 42(8)

Опубликована: Дек. 1, 2024

ABSTRACT Combination therapy offers a promising advantage because they target multiple pathways involved in the pathogenesis and progression of Alzheimer's disease. This study aimed to investigate synergistic effect donepezil each vitamin B12, B6 B1 on aluminium chloride (AlCl 3 )‐induced neurotoxicity rats. Fifty‐four rats were divided into nine groups six. Group I received distilled water, group II—AlCl (100 mg/kg), III‐ AlCl mg/kg) + Donepezil (10 IV‐AlCl Vitamin B12 (5 V‐AlCl VI‐AlCl VII‐AlCl VIII‐AlCl IX‐AlCl mg/kg). Treatment lasted for 40 days. Biochemical analyses brain revealed that chronic administration significantly increased level inflammatory cytokines, caspase 9, malondialdehyde, nitric oxide acetylcholinesterase (AChE) activity, while causing significant decrease superoxide dismutase (SOD) Nrf2, reduced glutathione, dopamine norepinephrine. Results also showed caused cognitive impairment as indicated by reduction percentage alternation index hypo‐activity towards novel object animals treated with only. Moreover, results from biochemical evaluations treatment donepezil, B vitamins combination attenuated deficits dopamine, norepinephrine, SOD reducing elevated levels oxide, AChE, 9 markers. These observations corroborated result histopathological evaluation. The proved be more effective than monotherapy. conferred protection against –induced neurotoxicity, however, performed better neuroprotective indices was amongst three therapies this study.

Язык: Английский

Oxidative Stress, Endoplasmic Reticulum Stress and Apoptosis in the Pathology of Alzheimer’s Disease DOI
Bidemi Emmanuel Ekundayo, Tajudeen Olabisi Obafemi, Olusola Bolaji Adewale

и другие.

Cell Biochemistry and Biophysics, Год журнала: 2024, Номер 82(2), С. 457 - 477

Опубликована: Март 12, 2024

Язык: Английский

Процитировано

34
Gallic acid and metformin co-administration reduce oxidative stress, apoptosis and inflammation via Fas/caspase-3 and NF-κB signaling pathways in thioacetamide-induced acute hepatic encephalopathy in rats DOI Creative Commons

Ehsan K. Mohamed,

Dawlat Mohamed Hafez

BMC Complementary Medicine and Therapies, Год журнала: 2023, Номер 23(1)

Опубликована: Июль 25, 2023

Hepatic encephalopathy (HE) is a consequence of chronic or acute liver diseases. This study evaluates the combined effect gallic acid (GA), and metformin (Met) on brain damage associated with HE.

Язык: Английский

Процитировано

11
PERFIL ELETROANALÍTICO DE NUTRACÊUTICOS ANTIOXIDANTES: IMPLICAÇÕES PARA A SAÚDE PÚBLICA DOI Open Access

Marcos Pereira Caetano,

Eric de Souza Gil,

Sylvia Escher de Oliveira Nielson

и другие.

Revista Foco, Год журнала: 2025, Номер 18(1), С. e7416 - e7416

Опубликована: Янв. 8, 2025

Objetivo: Neste trabalho buscamos avaliar diferentes amostras de nutracêuticos mais indicados por farmacêuticos em farmácias e Drogarias Goiânia, Goiás, Brasil. Posteriormente determinamos aspectos qualidade dos produtos majoritários, meio técnicas eletroanalíticas. Métodos: Doze comerciais capsulas, sendo (3 marcas cada tipo) foram avaliadas voltamétricas. Resultados: Os resultados evidenciaram, perfis voltametricos distintos para as Amora (Morus nigra), Açafrão (Curcuma longa), Chá verde (Camellia sinensis) Guaraná (Paullinia cupana) com picos oxidação próximos a Epa1 0,2 V. Identificamos uma diferença significativa na concentração entre (I, II III), há se destacar que todas são vendidas apelo comercial ser “idênticas”, o difere do resultado encontrado.

Процитировано

0
Cognitive enhancing effect of an extract of Swertia chirata against memory impairment induced by aluminum chloride DOI Creative Commons
Reena Deshmukh,

Manisha Jaiswal,

A. K. Shukla

и другие.

Brain Disorders, Год журнала: 2025, Номер unknown, С. 100190 - 100190

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

0
Comparing levetiracetam and zonisamide effects on rivastigmine anti-Alzheimer’s activity in aluminum chloride-induced Alzheimer’s-like disease in rats: Impact on α7 nicotinic acetylcholine receptors and amyloid β DOI

Raafat A. Abdel-Aal,

Fatma Y. Meligy,

Nashwa Maghraby

и другие.

Brain Research, Год журнала: 2025, Номер unknown, С. 149573 - 149573

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
Myco-fabricated ZnO nanoparticles ameliorate neurotoxicity in mice model of Alzheimer’s disease via acetylcholinesterase inhibition and oxidative stress reduction DOI Creative Commons

Hanan A. Abd Elmonem,

Reham M. Morsi,

Doaa S. Mansour

и другие.

BioMetals, Год журнала: 2023, Номер 36(6), С. 1391 - 1404

Опубликована: Авг. 9, 2023

Abstract Alzheimer’s disease (AD) is one of the primary health problems linked to decrease acetylcholine in cholinergic neurons and elevation oxidative stress. Myco-fabrication ZnO-NPs revealed excellent biological activities, including anti-inflammatory acetylcholinesterase inhibitory potentials. This study aims determine if two distinct doses myco-fabricated have a positive impact on behavioral impairment several biochemical markers associated with inflammation stress mice that been treated by aluminum chloride (AlCl 3 ) induce AD. Sixty male were haphazardly separated into equally six groups. Group 1 was injected i.p. 0.5 ml deionized water daily during experiment. Mice group 2 received AlCl (50 mg/kg/day i.p.). Groups 4 5 10 only, respectively. 6 given ZnO-NPs, respectively, add 50 . Results showed caused an increase escape latency time reduction spent target quadrant, indicating decreased improvement learning memory. Moreover, enzyme (AChE) activity malondialdehyde (MDA), tumor necrosis factor-alpha (TNF-α), interleukin 1β (IL-1β) levels significantly increased, content glutathione (GSH), activities superoxide dismutase (SOD), catalase (CAT), alanine aminotransferase (ALT), aspartate (AST), as well serotonin dopamine, brain tissues only mice. However, treatment myco-fabrication at or mg/kg improves memory function through ameliorate all previous parameters AD group. The low dose more effective than high mg/kg. In accordance these findings, could enhance exhibit protective influence against loss

Язык: Английский

Процитировано

9
Donepezil-based combination therapy for Alzheimer’s disease and related neuropathies DOI
Bidemi Emmanuel Ekundayo, Tajudeen Olabisi Obafemi, Olusola Bolaji Adewale

и другие.

Comparative Clinical Pathology, Год журнала: 2023, Номер 32(4), С. 699 - 708

Опубликована: Июнь 9, 2023

Язык: Английский

Процитировано

8
Phytochemical study, antioxidant and vasodilatation activities of leafy stem extracts of Flemingia faginea Guill. & Perr. (Barker), a medicinal plant used for the traditional treatment of arterial hypertension DOI Creative Commons
Windingoudi Rimwagna Christian Ouédraogo, Lazare Belemnaba, Mathieu Nitiéma

и другие.

Pharmacological Research - Modern Chinese Medicine, Год журнала: 2023, Номер 7, С. 100231 - 100231

Опубликована: Март 12, 2023

Язык: Английский

Процитировано

7
Identification and Quantification of Polyphenolic Secondary Metabolites in Stem Bark of Ficus religiosa (Moraceae) Using UPLC-HRMS and RP-HPLC-PDA DOI Creative Commons
Deepak Thakur, Uma Ranjan Lal, Deepak N. Kapoor

и другие.

Separations, Год журнала: 2023, Номер 10(6), С. 338 - 338

Опубликована: Май 31, 2023

F. religiosa bark has been extensively used in traditional medicinal systems, such as Ayurveda, for its health benefits. The aim of this study was to investigate the secondary metabolites (phenolics and flavonoids) hydroalcoholic stem-bark extract from because plant proven have a beneficial effect on disorders. Therefore, pilot conducted identification quantification polyphenolic compounds using sophisticated chromatographical techniques UPLC-HRMS RP-HPLC-PDA. Additionally, total flavonoids, phenolics scavenging profile were studied UV spectrophotometer. A 23 identified with mainly phenolic acids, polyphenolics, flavonoids (flavanols proanthocyanidins). Among compounds, gallic acid, catechin, epicatechin, epigallocatechin gallate, ellagic acid simultaneously quantified (0.031–0.380%) Thereafter, complied by evaluating (109.15 ± 1.2 mg RuE/g 33.78 0.86 CaE/g), (4.81 1.01 GaE/g), profiles (IC50 13.75 0.12 µg/mL) bark. This is first report chemical profiling bark, which necessary step evaluate nutraceutical properties, paving way possible food application.

Язык: Английский

Процитировано

7
In-vivo evaluation of neuroprotective effect of Chinese plant calendula officinalis Linn. Flower Extract against Aluminium chloride-induced Alzheimer's in Wistar rats DOI Creative Commons
Yash Jasoria, Mohit Agrawal, Shivendra Kumar

и другие.

Pharmacological Research - Modern Chinese Medicine, Год журнала: 2024, Номер 12, С. 100458 - 100458

Опубликована: Июнь 1, 2024

To investigate the neuroprotective properties of Calendula Officinalis Linn. flower extract (COE) against mild cognitive decline and dysfunction induced by aluminium chloride (AlCl3) in experimental rats. COE (100, 200, 300 mg/kg p.o.) was given once daily following treatment AlCl3 (100 to male Wistar rats for 20 days. On 1st, 10th, 20th days, walking track test, locomotor activity, object recognition test were used as behaviour characteristics assess spatial non-spatial memory. 21st day, animals sacrificed brains removed biochemical histopathological analysis. officinalis significantly attenuated AlCl3-induced alterations body weight, motor coordination such locomotion, stride length, parameters. also reduced oxidative stress increasing GSH, catalase, SOD, decreasing TBARS levels. high dose showed most prominent therapeutic effects. P<0.05 mean ± SD compare values with normal control, disease doses extract. Based on our study, has been proposed a mechanism neurotoxicity. We conclude that substantially decreased behavioural treated chloride. flowers may provide significant effects, potentially improving memory learning abilities. Linn contains anti-inflammatory antioxidant effects might be responsible its properties.

Язык: Английский

Процитировано

2