A Study on the Photoisomerization of (E)-Dehydrozingerone, Its (E)-(E)-C₂ Symmetric Dimer, and Their O-Methylated Derivatives DOI Creative Commons
Maria Antonietta Dettori, Valeria Ugone, Davide Fabbri

и другие.

Molecules, Год журнала: 2024, Номер 29(24), С. 5901 - 5901

Опубликована: Дек. 13, 2024

In this study, UV-induced (E)-to-(Z) geometrical isomerizations of the curcumin degradation product (E)-dehydrozingerone, along with curcumin-inspired (E)-O-methylated dehydrozingerone and their corresponding C2-symmetric dimers, were investigated. All compounds produced (Z) isomers in varying yields upon UV irradiation deuterated solvents. The efficiency these photoisomerizations depended on solvent wavelength used. While its (Z)-(Z) dimer proved to be highly unstable during purification, O-methylated derivatives successfully isolated, fully characterized by NMR spectroscopy, further analyzed UV-Vis spectroscopy computational methods.

Язык: Английский

Integrating network pharmacology, molecular docking, and experimental verification to demonstrate that Jiawei Duhuo Parasitic Decoction treated osteoarthritis by inhibiting PTGS2 expression DOI Creative Commons
Yang Duan, Jing Li, Yu Cheng

и другие.

Pharmacological Research - Modern Chinese Medicine, Год журнала: 2025, Номер unknown, С. 100601 - 100601

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
Evaluation of health resources and service utilization in traditional Chinese medicine hospitals in China based on WHO's comprehensive evaluation model DOI

Man-ci Zhou,

Bing Liu, Qi Gao

и другие.

Health Policy and Technology, Год журнала: 2025, Номер unknown, С. 100998 - 100998

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
Exploring Synergistic Benefits and Clinical Efficacy of Turmeric in Management of Inflammatory and Chronic Diseases: A Traditional Chinese Medicine Based Review DOI Creative Commons
Divya Jain, Kuldeep Singh,

Paras Gupta

и другие.

Pharmacological Research - Modern Chinese Medicine, Год журнала: 2025, Номер unknown, С. 100572 - 100572

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
Artificial intelligence-driven innovation in Ganoderma spp.: potentialities of their bioactive compounds as functional foods DOI Creative Commons
Sonali Khanal, Aman Sharma,

M. Radhakrishna Pillai

и другие.

Sustainable Food Technology, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

AI significantly transforms the food business by optimizing production processes of therapeutic Ganoderma spp. and improving quality safety control based functional food.

Язык: Английский

Процитировано

0
Garlic ameliorates atherosclerosis by regulating ferroptosis pathway: an integrated strategy of network pharmacology, bioinformatic and experimental verification DOI Creative Commons
Tingting Gao, Siqi Gao, Heng Wang

и другие.

Frontiers in Pharmacology, Год журнала: 2024, Номер 15

Опубликована: Июль 23, 2024

Background Atherosclerosis (AS) is a chronic arterial pathology and leading cause of vascular disease-related mortality. Fatty streaks in the wall develop into atherosclerosis characteristic plaques. Clinical interventions typically involve lipid-lowering medications drugs for stabilizing vulnerable plaques, but no direct therapeutic agent specifically targets atherosclerosis. Garlic, also locally known as DASUAN, recognized widely sold herbal dietary supplement esteemed its cardiovascular benefits. However, specific mechanisms garlic’s anti-atherosclerotic effects remain unclear. Aims This study aims to elucidate pharmacological through which garlic ameliorates Methods The identified major active components by screening TCMSP, TCM-ID, and, ETCM databases. Atherosclerosis-associated were obtained from DisGeNET, GeneCards, DiGSeE databases, intervention determined intersection. Utilizing intersected genes, Gene Ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) pathway enrichment analyses conducted using R software. A component-disease target network was constructed Cytoscape. RNA-seq datasets GEO database utilized identify differentially expressed genes (DEGs) associated with DEGs FerrDb (ferroptosis database). Molecular docking predicted binding interactions between core targets. In vitro vivo experiments validated Results integration drug atherosclerotic disease 230 genes. Intersection revealed 15 upregulated including 8 related ferroptosis. indicated favorable affinities [Sobrol A, (+)-L-Alliin, Benzaldoxime, Allicin] (DPP4, ALOX5, GPX4). Experimental validation showed that GARLIC reduces expression ferroptosis-related AS, suggesting potential regulation Conclusion Garlic targeting intra-plaque ferroptosis reducing lipid peroxidation. These findings provide novel insights underlying efficacy treating AS.

Язык: Английский

Процитировано

3
Ginsenosides: an immunomodulator for the treatment of colorectal cancer DOI Creative Commons

Jianan Qian,

Yanyu Jiang, Hongyi Hu

и другие.

Frontiers in Pharmacology, Год журнала: 2024, Номер 15

Опубликована: Июнь 12, 2024

Ginsenosides, the primary bioactive ingredients derived from root of Panax ginseng, are eagerly in demand for tumor patients as a complementary and alternative drug. Ginsenosides have increasingly become “hot topic” recent years due to their multifunctional role treating colorectal cancer (CRC) regulating microenvironment (TME). Emerging experimental research on ginsenosides treatment immune regulation CRC has been published, while no review sums up its specific microenvironment. Therefore, this paper systematically introduces how affect TME, specifically by enhancing response, inhibiting activation stromal cells, altering hallmarks cells. In addition, we discuss impact physicochemical properties Furthermore, application clinical efficacy patient immunity prolonging survival. The future perspectives ginsenoside drug also provided. This hopes open new horizon Traditional Chinese Medicine monomers.

Язык: Английский

Процитировано

2
A systematic review on anticancer potential of Traditional Chinese Medicine (Yang Zheng XiaoJi) DOI Creative Commons
Krishn Kumar Agrawal, Yogesh Murti

Pharmacological Research - Modern Chinese Medicine, Год журнала: 2024, Номер unknown, С. 100505 - 100505

Опубликована: Сен. 1, 2024

Язык: Английский

Процитировано

1
Acorus gramineus extract decreases cancer stem cell properties and stimulates ROS signaling pathway in HepG2 hepatocellular carcinoma cells DOI Creative Commons
Van Hung Hoang, Lê Thị Hương,

Phu Hung Nguyen

и другие.

Pharmacological Research - Modern Chinese Medicine, Год журнала: 2024, Номер unknown, С. 100548 - 100548

Опубликована: Ноя. 1, 2024

Язык: Английский

Процитировано

1
Exploiting the nanotechnological approaches for traditional Chinese medicine in childhood rhinitis: A review of future perspectives DOI Creative Commons
Yao Zhang,

Haicheng Dong,

Yu Zhu

и другие.

Nanotechnology Reviews, Год журнала: 2024, Номер 13(1)

Опубликована: Янв. 1, 2024

Abstract Childhood rhinitis is an inflammatory condition affecting the nasal mucosa of children worldwide. The physical, social, and cognitive performance affected by chronic symptoms childhood rhinitis. Effective treatment essential to avoid long-term effects on children’s lifestyles well-being. Traditional Chinese medicine (TCM) has been used treat prevent several illnesses, it plays a crucial role in healthcare rehabilitation. TCM traditionally holistically However, drawbacks TCMs, such as their poor water solubility, low bioavailability, single-use, targeting ability, severely restrict use. In recent years, nanotechnology for various drugs improve therapeutic effectiveness reduce associated adverse effects. Nanomaterials formulations are synthesized be compatible with herbal extracts sustain active component qualities. Nanocarrier-based drug delivery improves circulation time, targeted distribution, resolving administration issues. This review assesses innovative combination developments rhinitis, providing insights into novel approaches. also provides significant potential this multidisciplinary approach transform techniques offers road map future research initiatives promising sector.

Язык: Английский

Процитировано

0
A Study on the Photoisomerization of (E)-Dehydrozingerone, Its (E)-(E)-C₂ Symmetric Dimer, and Their O-Methylated Derivatives DOI Creative Commons
Maria Antonietta Dettori, Valeria Ugone, Davide Fabbri

и другие.

Molecules, Год журнала: 2024, Номер 29(24), С. 5901 - 5901

Опубликована: Дек. 13, 2024

In this study, UV-induced (E)-to-(Z) geometrical isomerizations of the curcumin degradation product (E)-dehydrozingerone, along with curcumin-inspired (E)-O-methylated dehydrozingerone and their corresponding C2-symmetric dimers, were investigated. All compounds produced (Z) isomers in varying yields upon UV irradiation deuterated solvents. The efficiency these photoisomerizations depended on solvent wavelength used. While its (Z)-(Z) dimer proved to be highly unstable during purification, O-methylated derivatives successfully isolated, fully characterized by NMR spectroscopy, further analyzed UV-Vis spectroscopy computational methods.

Язык: Английский

Процитировано

0