Biotechnology Progress,
Год журнала:
2023,
Номер
39(6)
Опубликована: Авг. 29, 2023
Abstract
Altered
expression
of
multiple
miRNAs
was
found
to
be
extensively
involved
in
the
pathogenesis
different
neurological
disorders
including
Alzheimer's
disease,
Parkinson's
stroke,
epilepsy,
sclerosis,
amyotrophic
lateral
and
Huntington's
disease.
One
biggest
concerns
within
gene‐based
therapy
is
delivery
therapeutic
microRNAs
intended
place,
which
obligated
surpass
biological
barriers
without
undergoing
degradation
bloodstream
or
renal
excretion.
Hence,
modified
unmodified
miRNA
molecules
using
excellent
vehicles
required.
In
this
light,
mesenchymal
stem
cells
(MSCs)
have
attracted
increasing
attention.
The
MSCs
can
genetically
express
overexpress
a
particular
microRNA
aimed
with
promote
neurogenesis
neuroprotection.
current
review
has
focused
on
capabilities
microRNAs‐overexpressing
ameliorate
functional
deficits
conditions.
Abstract
The
use
of
nanotechnology
has
the
potential
to
revolutionize
detection
and
treatment
cancer.
Developments
in
protein
engineering
materials
science
have
led
emergence
new
nanoscale
targeting
techniques,
which
offer
renewed
hope
for
cancer
patients.
While
several
nanocarriers
medicinal
purposes
been
approved
human
trials,
only
a
few
authorized
clinical
cells.
In
this
review,
we
analyze
some
formulations
discuss
challenges
translating
findings
from
lab
clinic.
This
study
highlights
various
compounds
that
can
be
used
selective
tumor
inherent
difficulties
therapy.
Nanotechnology
provides
promising
platform
improving
future,
but
further
research
is
needed
overcome
current
limitations
translation.
Graphical
The
advent
of
iPSCs
has
brought
about
a
significant
transformation
in
stem
cell
research,
opening
up
promising
avenues
for
advancing
cancer
treatment.
formation
is
multifaceted
process
influenced
by
genetic,
epigenetic,
and
environmental
factors.
offer
distinctive
platform
investigating
the
origin
cancer,
paving
way
novel
approaches
to
treatment,
drug
testing,
tailored
medical
interventions.
This
review
article
will
provide
an
overview
science
behind
iPSCs,
current
limitations
challenges
iPSC-based
therapy,
ethical
social
implications,
comparative
analysis
with
other
types
also
discuss
applications
tumorigenesis,
future
tumorigenesis
highlight
successful
case
studies
utilizing
research.
conclusion
summarize
advancements
made
research
importance
continued
investment
iPSC
unlock
full
potential
these
cells.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(18), С. 13900 - 13900
Опубликована: Сен. 9, 2023
In
an
ever-increasing
aged
world,
Alzheimer’s
disease
(AD)
represents
the
first
cause
of
dementia
and
one
chronic
diseases
in
elderly
people.
With
55
million
people
affected,
WHO
considers
AD
to
be
a
with
public
priority.
Unfortunately,
there
are
no
final
cures
for
this
pathology.
Treatment
strategies
aimed
mitigate
symptoms,
i.e.,
acetylcholinesterase
inhibitors
(AChEI)
N-Methyl-D-aspartate
(NMDA)
antagonist
Memantine.
At
present,
best
approaches
managing
seem
combine
pharmacological
non-pharmacological
therapies
stimulate
cognitive
reserve.
Over
last
twenty
years,
number
drugs
have
been
discovered
acting
on
well-established
biological
hallmarks
AD,
deposition
β-amyloid
aggregates
accumulation
hyperphosphorylated
tau
protein
cells.
Although
previous
efforts
disappointed
expectations,
new
era
treating
has
working
its
way
recently.
The
Food
Drug
Administration
(FDA)
gave
conditional
approval
disease-modifying
therapy
(DMT)
treatment
aducanumab,
monoclonal
antibody
(mAb)
designed
against
Aβ
plaques
oligomers
2021,
January
2023,
FDA
granted
accelerated
second
antibody,
Lecanemab.
This
review
describes
ongoing
clinical
trials
DMTs
therapies.
We
will
also
present
future
scenario
based
biomarkers
that
can
detect
preclinical
or
prodromal
stages,
identify
at
risk
developing
allow
early
curative
treatment.
IntechOpen eBooks,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 8, 2024
Peripheral
nervous
system
(PNS)
injuries
pose
a
significant
clinical
challenge,
often
resulting
in
motor,
sensory,
or
autonomic
dysfunction
that
impacts
patients’
quality
of
life.
Despite
the
PNS’s
capacity
for
regeneration,
outcomes
are
not
always
satisfactory.
In
response
to
these
challenges,
new
research
is
encouraged
provide
more
effective
therapeutic
approaches.
this
context,
cellular
therapy
emerges
as
promising
alternative.
Evidence
potential
Schwann
cells
(SCs)
PNS
has
been
observed,
yet
their
application
faces
limitations.
To
address
difficulties,
several
studies
have
highlighted
ability
mesenchymal
stem
(MSCs)
transdifferentiate
into
Schwann-like
(SLCs),
holding
treating
peripheral
nerve
injuries.
Therefore,
chapter
only
reviews
involvement
SCs
regeneration
but
also
provides
an
overview
recent
advancements
developing
SLCs
derived
from
MSCs
and
Additionally,
it
explores
future
perspective
manufacturing
guidance
conduits
(NGCs).
This
review
article
examines
the
effectiveness
of
incorporating
autologous
endometrial
cells
and
platelet-rich
plasma
(PRP)
through
hysteroscopic
injections
within
field
assisted
reproductive
technology
(ART).
study
assesses
outcomes
these
on
susceptibility
endometrium,
dynamics
uterus,
frequencies
pregnancy
in
individuals
with
refractory
thin
endometrium.
Based
a
complete
examination
several
trials,
it
becomes
apparent
that
PRP
provide
encouraging
turnouts
augmenting
thickness,
raising
receptivity,
and,
end,
chances
being
pregnant
successful
delivery.
The
research
highlights
promise
minimally
changed
cellular
treatments
enhancing
ART,
especially
for
people
who
have
had
problems
implantation.
gives
whole
evaluation
medical
use
upgrades
regarding
utilization
infusions
under
control
to
deal
infertility
issues
related
health
synthesis
contemporary
studies.
PubMed,
Год журнала:
2024,
Номер
27(9), С. 1187 - 1196
Опубликована: Янв. 1, 2024
Enhancement
of
proliferation,
pluripotency,
and
self-renewal
capacity
as
the
unique
features
MSCs
can
improve
their
therapeutic
potential
to
regenerate
tissues.
In
this
context,
crocin
curcumin,
carotenoid
compounds
with
outstanding
medicinal
properties,
could
be
promising
for
cell
protection
growth.
This
study
aimed
evaluate
impact
nanocurcumin
on
BM-MSCs
proliferation
pluripotency
