Research Square (Research Square), Год журнала: 2025, Номер unknown

Опубликована: Апрель 7, 2025

Epilepsy is a widespread neurological disorder affecting over 70 million individuals globally, with approximately 4.9 new cases diagnosed annually. Despite extensive research, the underlying mechanisms of epilepsy remain incompletely elucidated. MicroRNAs (miRNAs) are being increasingly utilized as crucial biomarkers in various disorders, and their targeting proteins involved disease pathogenesis represents promising therapeutic strategy. This study aimed to identify novel candidate miRNAs associated evaluate diagnostic potential. The expression profiles 84 were analyzed plasma samples from 20 patients 25 controls using qRT-PCR on BioMarkTM 96.96 Dynamic Array (Fluidigm Corporation) system. In group, total 44 exhibited decreased compared control which 24 statistically significant. Notably, 18 demonstrated highly significant reduction levels (p< 0.0001). These include hsa-let-7e-5p, hsa-miR-105-5p, hsa-miR-106b-5p, hsa-miR-107, hsa-miR-125b-5p, hsa-miR-128, hsa-miR-135b-5p, hsa-miR-138-5p, hsa-miR-152, hsa-miR-15a-5p, hsa-miR-193b-3p, hsa-miR-203a, hsa-miR-339-5p, hsa-miR-381-3p, hsa-miR-409-3p, hsa-miR-511, hsa-miR-539-5p, hsa-miR-7-5p. 40 increased among 28 23 increase (p < hsa-miR-101-3p, hsa-miR-130a-3p, hsa-miR-132-3p, hsa-miR-146a-5p, hsa-miR-146b-5p, hsa-miR-181a-5p, hsa-miR-212-3p, hsa-miR-27a-3p, hsa-miR-28-5p, hsa-miR-302b-5p, hsa-miR-337-3p, hsa-miR-338-3p, hsa-miR-34a-5p, hsa-miR-455-5p, hsa-miR-485-5p, hsa-miR-487a, hsa-miR-499a-5p, hsa-miR-509-3p, hsa-miR-512-3p, hsa-miR-518b, hsa-miR-652-3p, hsa-miR-9-3p, hsa-miR-95. findings suggest that hold potential innovative, non-invasive for early detection diagnosis epilepsy, offering avenue advancing clinical practices.

Язык: Английский