Chinese Chemical Letters, Год журнала: 2024, Номер unknown, С. 110686 - 110686
Опубликована: Ноя. 1, 2024
Язык: Английский
International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(5), С. 1868 - 1868
Опубликована: Фев. 21, 2025
The phosphoinositide 3-kinase (PI3K)/AKT/mammalian target of the rapamycin (mTOR) pathway plays a crucial role in regulation autophagy, cellular mechanism vital for homeostasis through degradation damaged organelles and proteins. dysregulation this is significantly associated with cancer progression, metastasis, resistance to therapy. Targeting PI3K/AKT/mTOR signaling presents promising strategy treatment; however, traditional therapeutics frequently encounter issues related nonspecific distribution systemic toxicity. Nanoparticle-based drug delivery systems represent significant advancement addressing these limitations. Nanoparticles enhance bioavailability, stability, targeted therapeutic agents, facilitating precise modulation autophagy cells. Functionalized nanoparticles, such as liposomes, polymeric metal-based nanocarriers, facilitate tumor tissues, minimizing off-target effects improving efficacy. These can deliver multiple agents concurrently, enhancing PI3K/AKT/mTOR-mediated oncogenic pathways. This review examines advancements nanoparticle-mediated that pathway, emphasizing their contribution precision side integration nanotechnology molecularly therapies substantial potential resistance. Future initiatives must prioritize optimization clinical translation patient outcomes.
Язык: Английский
Процитировано
1
Journal of Biological Engineering, Год журнала: 2024, Номер 18(1)
Опубликована: Фев. 5, 2024
Abstract Bone metastasis is considered as a considerable challenge for breast cancer patients. Various in vitro and vivo models have been developed to examine this occurrence. In are employed simulate the intricate tumor microenvironment, investigate interplay between cells their adjacent evaluate effectiveness of therapeutic interventions tumors. The endeavor replicate latency period bone animal has presented challenge, primarily due necessity primary removal presence multiple potential metastatic sites. utilization novel models, including three-dimensional (3D) proposed promising approach overcome constraints associated with conventional 2D models. However, existing 3D limited by various factors, such irregular cellular proliferation, autofluorescence, changes genetic epigenetic expression. imperative advancement future applications lies standardization automation. artificial intelligence exhibits capability predict behavior through examination substrate materials' chemical composition, geometry, mechanical performance. implementation these algorithms possesses progression proliferation cancer. This paper reviewed mechanisms following Current metastasis, along challenges, well perspectives using translational drug development, were discussed.
Язык: Английский
Процитировано
5
European Polymer Journal, Год журнала: 2024, Номер 213, С. 113133 - 113133
Опубликована: Май 16, 2024
Язык: Английский
Процитировано
4
Experimental Cell Research, Год журнала: 2025, Номер unknown, С. 114439 - 114439
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0
Frontiers in Bioengineering and Biotechnology, Год журнала: 2024, Номер 12
Опубликована: Сен. 5, 2024
Bone structures facilitate the regeneration and repair of bone tissue in regions where it has been damaged or destroyed, either temporarily permanently. Therefore, bone's fatigue strength durability are crucial to its efficacy longevity. Several variables, such as construct's material qualities, design, production procedure, loading unloading cycles, physiological conditions influence endurance life constructs. Metals, ceramics, polymers all routinely utilized create substitutes, each these materials unique features that might affect final product. The mechanical performance capacity promote may be affected by scaffold's porosity, pore size. Researchers employ testing under cyclic circumstances one example an experimental approach used assess construction endurance. These analyses can give us important information about stress-strain behavior, resistance multiple new structure. Predicting developed construct also possible with use simulations numerical analyses. Hence, order reliable efficient constructs for engineering, is understand their durability. purpose this study analyze effective parameters gather models evaluations assessments.
Язык: Английский
Процитировано
3
International Journal of Biological Macromolecules, Год журнала: 2023, Номер 258, С. 128482 - 128482
Опубликована: Ноя. 30, 2023
Язык: Английский
Процитировано
7
International Journal of Biological Macromolecules, Год журнала: 2024, Номер 280, С. 135999 - 135999
Опубликована: Сен. 24, 2024
Язык: Английский
Процитировано
1
Journal of Biological Engineering, Год журнала: 2024, Номер 18(1)
Опубликована: Сен. 9, 2024
Язык: Английский
Процитировано
0
Advances in Clinical Medicine, Год журнала: 2024, Номер 14(09), С. 1297 - 1306
Опубликована: Янв. 1, 2024
Язык: Английский
Процитировано
0
Chinese Chemical Letters, Год журнала: 2024, Номер unknown, С. 110686 - 110686
Опубликована: Ноя. 1, 2024
Язык: Английский
Процитировано
0