Medicine - Programa de Formación Médica Continuada Acreditado, Год журнала: 2024, Номер 14(23), С. 1364 - 1384
Опубликована: Дек. 1, 2024
International Journal of Oncology, Год журнала: 2024, Номер 65(6)
Опубликована: Окт. 22, 2024
Significant advancements have been made in cancer therapy; however, limitations remain with some conventional approaches. Adjuvants are agents used alongside primary treatments to enhance their efficacy and the treatment outcomes of patients. Modern lifestyles contribute deficiencies melatonin vitamin D. Limited sun exposure affects D synthesis, artificial light at night suppresses production. Both possess anti‑inflammatory, immune‑boosting anticancer properties, rendering them potential adjuvants interest. Studies suggest supplementation may address antioxidant imbalances lip, oral pharyngeal cancers. Moreover, promising results from breast, head neck, brain, osteosarcoma research indicate for tumor growth inhibition, improved survival, a better quality life patients cancer. The radioprotective properties another exciting area exploration, potentially enhancing radiotherapy effectiveness while reducing side effects. For its part, sleep‑promoting effects indirectly benefit by influencing immune system. Thus, prevalence highlights importance supplementation, as lower levels can worsen side‑effects treatments. present review explores combining synergistic therapy. These shown promise individually prevention treatment, combined warrant investigation. Therefore, large‑scale controlled trials crucial definitively determine optimal dosage, safety this combination improving lives
Язык: Английский
Процитировано
4
Pathology - Research and Practice, Год журнала: 2024, Номер 254, С. 155160 - 155160
Опубликована: Янв. 20, 2024
Язык: Английский
Процитировано
1
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Год журнала: 2024, Номер 1870(7), С. 167286 - 167286
Опубликована: Июнь 12, 2024
Язык: Английский
Процитировано
1
Interdisciplinary cancer research, Год журнала: 2024, Номер unknown
Опубликована: Янв. 1, 2024
Melatonin is a ubiquitous molecule on the phylogenetic scale, and cancer genes, inherent to coexistence cooperation between cells, appeared with multicellularity in ancestral metazoans. It not surprising that functional network of indoleamine intersects malfunction pathways responsible for during evolution. Attention paid melatonin over past decades has revealed extraordinary pleiotropy involving synchronization endogenous rhythms, control redox metabolism, receptor-mediated downstream signaling, (epi)genetic regulation, among others. This multiplicity actions outlines as protective agent prevents both damage cellular structures alteration homeostasis. Instead, represents tectonic convulsion stabilization mechanisms put them at service uncontrolled growth propagation. From this perspective, it clear biochemistry placed center scene and, more importantly, its functionalities can be potentially antagonistic. Research biology given rise an important volume epidemiological, vitro, animal studies all together point directly indirectly ability inhibit critical carcinogenesis steps. However, there still much basic translational knowledge achieved, namely systematic research programs models clinical trials would clarify possibilities prevention treatment disease. Information continues accumulate ongoing needs regular state-of-the-art updates. chapter attempts answer concern by summarizing latest findings mechanistic processes tumor development. In addition, recent evidence therapeutic capacity setting patients presented.
Язык: Английский
Процитировано
0
Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2024, Номер unknown
Опубликована: Сен. 17, 2024
Язык: Английский
Процитировано
0
Medicine - Programa de Formación Médica Continuada Acreditado, Год журнала: 2024, Номер 14(23), С. 1364 - 1384
Опубликована: Дек. 1, 2024
Процитировано
0