Beilstein Journal of Nanotechnology,
Год журнала:
2024,
Номер
15, С. 1619 - 1626
Опубликована: Дек. 16, 2024
Biomimetic
nanocarriers,
engineered
to
mimic
the
characteristics
of
native
cells,
offer
a
revolutionary
approach
in
treatment
various
complex
human
diseases.
This
strategy
enhances
drug
delivery
by
leveraging
innate
properties
cellular
components,
thereby
improving
biocompatibility
and
targeting
specificity.
nanocarriers
demonstrate
significant
advancements
systems
against
cancer
therapy,
Alzheimer's
disease,
autoimmune
diseases,
viral
infections
such
as
COVID-19.
Here,
we
address
therapeutic
applications
biomimetic
their
promising
for
personalized
medicine.
Cell Biology and Toxicology,
Год журнала:
2025,
Номер
41(1)
Опубликована: Май 23, 2025
The
advent
of
nanotechnology
has
significantly
advanced
the
diagnosis
and
treatment
oral
cancer,
offering
more
precise
efficient
therapeutic
strategies.
This
review
presents
a
comprehensive
overview
recent
developments
in
application
to
cancer
management.
It
begins
with
an
epidemiology
outlines
current
diagnostic
methods.
classification
advantages
various
nanomaterials
are
then
introduced.
paper
thoroughly
explores
use
as
drug
delivery
systems
(DDSs),
imaging
contrast
agents,
tools,
particular
emphasis
on
multifunctional
nanoplatforms
that
integrate
diagnostics
therapy.
These
platforms
enable
real-time
monitoring
immediate
response,
innovative
approaches
for
early
detection
intervention.
Despite
these
promising
advances,
several
challenges
persist,
including
issues
related
biocompatibility,
clearance,
targeting
specificity,
clinical
translation.
concludes
by
highlighting
limitations
proposing
future
directions
treatment.
Advanced Pharmaceutical Bulletin,
Год журнала:
2024,
Номер
14(3), С. 634 - 645
Опубликована: Июнь 29, 2024
Purpose:
We
report
on
the
design
of
hypoxia-induced
dual-stage
acting
dendrimeric
nanoparticles
(NPs)
for
selective
delivery
two
chemotherapeutic
model
drugs
doxorubicin
(DOX)
and
tirapazamin
(TPZ)
deepened
drug
into
hypoxic
tumors
in
vitro.
Methods:
PAMAM
G5
dendrimers
were
crosslinked
with
a
azo
linker,
attached
to
mPEG
form
detachable
corona
dendrimer
surface
(PAP
NPs).
NPs
characterized
by
Zeta
sizer,
transmission
electron
microscope
(TEM),
Fourier
transforms
infrared
(FTIR)
release
kinetics.
The
anti-cancer
performance
PAPs
was
evaluated
numerous
tests
2D
3D
cultured
MDA-MB-231
breast
cancer
cells.
Results:
MTT
assay
showed
significant
difference
between
PAP
PAMAMG5
terms
biocompatibility,
effect
PAP@DOX
significantly
greater
than
free
DOX
conditions.
results
DAPI
Annexin
V-FITC/PI
cell
staining
also
confirmed
uniform
penetration
as
validated
induction
90%
apoptosis
spheroids
high
level
PAP@DOX-induced
ROS
generation
under
hypoxia
Mechanistically,
reduced
expression
mTOR,
Notch1,
while
Bax
Caspase3
considerably
unregulated,
compared
controls.
Importantly,
hypoxia-responsive
disintegration
activation
HAP
synergized
promote
deep
homogenous
distribution
whole
microtumor
regions
efficiently
eliminate
residual
tumor
Conclusion:
Our
indicate
safety
therapeutic
potential
system
targeted
chemotherapeutics
particular
HAPs
which
show
maximum
activity
against
solid
tumors.
World Journal of Gastrointestinal Oncology,
Год журнала:
2025,
Номер
17(4)
Опубликована: Март 24, 2025
Gastrointestinal
(GI)
cancers,
which
predominantly
manifest
in
the
stomach,
colorectum,
liver,
esophagus,
and
pancreas,
accounting
for
approximately
35%
of
global
cancer-related
mortality.
The
advent
liquid
biopsy
has
introduced
a
pivotal
diagnostic
modality
early
identification
premalignant
GI
lesions
incipient
cancers.
This
non-invasive
technique
not
only
facilitates
prompt
therapeutic
intervention,
but
also
serves
as
critical
adjunct
prognosticating
likelihood
tumor
recurrence.
wealth
circulating
exosomes
present
body
fluids
is
often
enriched
with
proteins,
lipids,
microRNAs,
other
RNAs
derived
from
cells.
These
specific
cargo
components
are
reflective
processes
involved
tumorigenesis,
progression,
response
to
treatment.
As
such,
they
represent
group
promising
biomarkers
aiding
diagnosis
cancer.
In
this
review,
we
delivered
an
exhaustive
overview
composition
pathways
sorting
within
these
vesicles.
We
laid
out
some
clinical
evidence
that
supported
utilization
cancers
discussed
their
potential
application.
Furthermore,
addressed
challenges
encountered
when
harnessing
predictive
instruments
realm
Journal of the Egyptian National Cancer Institute,
Год журнала:
2025,
Номер
37(1)
Опубликована: Май 1, 2025
Extracellular
vesicles
(EVs)
have
emerged
as
key
cell-to-cell
communication
mediators
and
play
significant
roles
in
both
physiological
pathological
processes.
In
EVs,
exosomes
represent
a
distinct
subpopulation
of
EVs
that
been
found
to
be
involved
cancer
initiation
therapeutic
resistance.
Exosomes
transfer
diverse
spectrum
molecular
cargos
effects
on
the
tumor
microenvironment
(TME),
thereby
enabling
initiation,
metastasis,
recently
interest
therapy
due
their
role
important
treatment
The
exosomal
content-proteins,
miRNAs,
lncRNAs-allows
perform
functions
including
drug
efflux
detoxification,
cell
death
pathway
modulation,
induction
epithelial-to-mesenchymal
transition
(EMT),
suppression
immune
system.
addition
facilitating
stromal
interactions,
cause
extracellular
matrix
remodeling
induce
heterogeneity,
making
it
more
difficult
respond
therapy.
This
review
covers
intricate
resistance
with
regard
biogenesis,
content,
functional
impact
TME.
Along
this,
we
also
discuss
new
strategies
overcome
exosome-mediated
utilizing
exosome
inhibitors,
designed
therapy,
combination
conventional
therapies.
While
hold
promise
prediction
diagnosis
through
biomarker
function,
heterogeneous
origins
cryptic
make
target
interventions.
emphasizes
research
pathways
is
urgently
required
develop
can
improve
outcomes.
International Journal of Cancer,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 2, 2025
Abstract
Cancer
remains
one
of
the
leading
causes
death
worldwide.
Despite
remarkable
progress
in
prevention,
diagnosis,
and
therapy,
incidence
certain
types
cancer
persists,
urging
identification
clinically
relevant
biomarkers
development
novel
therapeutic
strategies
to
improve
clinical
outcomes
overcome
treatment
resistance.
Exosomes,
small
extracellular
vesicles
released
by
diverse
cells,
have
attracted
interest
biomedical
research
due
their
potential
as
carriers
for
different
treatments.
Moreover,
exosomes
play
a
pivotal
role
intercellular
communication,
modulating
various
cellular
processes.
One
those
is
autophagy,
pro‐survival
pathway
that
essential
human
cells.
Even
though
autophagy
traditionally
described
catabolic
route,
its
machinery
intricately
involved
responses,
including
vesicle
formation
secretion.
In
this
regard,
link
between
complex,
bidirectional,
highly
dependent
on
context.
Interestingly,
both
processes
been
extensively
implicated
pathogenesis,
highlighting
targets.
This
review
updates
our
understanding
how
can
participate
progression,
with
specific
focus
influence
tumor
growth,
angiogenesis,
metastasis.
Additionally,
interplay
these
minutely
reviewed
discussed,
we
hypothesize
crosstalk
may
hold
valuable
clues
biomarker
discovery
strategies.
ACS Applied Bio Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 14, 2025
Extracellular
vesicles
are
nanoscale
released
by
a
diversity
of
cells
that
mediate
intercellular
communication
transporting
an
array
biomolecules.
They
gaining
increasing
attention
in
cancer
research
due
to
their
ability
carry
specific
biomarkers.
This
characteristic
makes
them
potentially
useful
for
highly
sensitive,
noninvasive
diagnostic
procedures
and
more
precise
prognostic
assessments.
Consequently,
EVs
emerging
as
transformative
tool
treatment,
facilitating
early
detection
personalized
medicine.
Despite
significant
progress,
clinical
implementation
is
hindered
challenges
EV
isolation,
purification,
characterization.
However,
developing
advanced
biosensor
technologies
offers
promising
solutions
these
obstacles.
review
highlights
recent
progress
biosensors
analysis,
focusing
on
various
sensing
modalities
including
optical,
electrochemical,
microfluidic,
nanomechanical,
biological
sensors.
We
also
explore
techniques
characterization,
such
electron
microscopy,
atomic
force
nanoparticle
tracking
single-particle
analysis.
Furthermore,
the
critically
assesses
associated
with
put
forward
future
directions,
aiming
usher
cutting-edge
era
precision
medicine
through
advanced,
sensor-based,
diagnosis
detecting
EV-carried
Beilstein Journal of Nanotechnology,
Год журнала:
2024,
Номер
15, С. 1619 - 1626
Опубликована: Дек. 16, 2024
Biomimetic
nanocarriers,
engineered
to
mimic
the
characteristics
of
native
cells,
offer
a
revolutionary
approach
in
treatment
various
complex
human
diseases.
This
strategy
enhances
drug
delivery
by
leveraging
innate
properties
cellular
components,
thereby
improving
biocompatibility
and
targeting
specificity.
nanocarriers
demonstrate
significant
advancements
systems
against
cancer
therapy,
Alzheimer's
disease,
autoimmune
diseases,
viral
infections
such
as
COVID-19.
Here,
we
address
therapeutic
applications
biomimetic
their
promising
for
personalized
medicine.
