Epigenomics, Год журнала: 2024, Номер 16(14), С. 1043 - 1055
Опубликована: Июль 17, 2024
Cerebrovascular diseases, especially stroke, are critical and heterogenous clinical conditions associated with high mortality chronic disability. Genome-wide association studies reveal substantial stroke heritability, though specific genetic variants account for a minor fraction of risk, suggesting an essential role the epigenome. Epigenome-wide candidate gene approaches show that DNA methylation patterns significantly influence susceptibility. Additionally, chromatin remodelers non-coding RNA regulate expression in response to ischemic conditions. In this updated review, we summarized progress knowledge on epigenetics field underlying opportunities challenges.
Язык: Английский