Dysregulation of miRNAs in Schizophrenia in an Egyptian Patient Population DOI

Noha Adly,

Dalia Khalifa,

Shaimaa Abdel-Ghany

и другие.

Research Square (Research Square), Год журнала: 2025, Номер unknown

Опубликована: Апрель 14, 2025

Abstract Schizophrenia (SZ) is a complex neuropsychiatric disorder influenced by genetic, environmental, and epigenetic factors, including miRNA dysregulation. This study explored the diagnostic therapeutic potential of miRNAs in SZ, focusing on seven key miRNAs: miR-137-3p, miR-34a-5p, miR-432-5p, miR-130b-3p, miR-346, miR-195-5p, miR-103a-3p. Results revealed significant dysregulation miR-103a-3p, highlighting their relevance to SZ pathology. Upregulation miR-137-3p correlated with enhanced cognitive performance, as evidenced improved scores Wisconsin Card Sorting Test (WCST) Trail Making B (TMT-B). Conversely, miR-195-5p miR-346 were strongly associated processing speed, while miR-103a-3p downregulation was linked reduced conceptual flexibility. Cluster analyses demonstrated that expression levels varied significantly based antipsychotic treatment receptor targeting, suggesting regulatory effects medication. Importantly, measured PBMCs, feasibility non-invasive biomarkers. The underscores value miRNAs, offering promising avenue for early detection personalized interventions SZ. Future research should validate these findings across diverse cohorts investigate miRNA-based strategies. By integrating profiling into clinical practice, this provides foundation advancing precision medicine management.

Язык: Английский

Epigenetic Control in Schizophrenia DOI
Claudio D’Addario, Martina Di Bartolomeo

Sub-cellular biochemistry/Subcellular biochemistry, Год журнала: 2025, Номер unknown, С. 191 - 215

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
Dysregulation of miRNAs in Schizophrenia in an Egyptian Patient Population DOI

Noha Adly,

Dalia Khalifa,

Shaimaa Abdel-Ghany

и другие.

Research Square (Research Square), Год журнала: 2025, Номер unknown

Опубликована: Апрель 14, 2025

Abstract Schizophrenia (SZ) is a complex neuropsychiatric disorder influenced by genetic, environmental, and epigenetic factors, including miRNA dysregulation. This study explored the diagnostic therapeutic potential of miRNAs in SZ, focusing on seven key miRNAs: miR-137-3p, miR-34a-5p, miR-432-5p, miR-130b-3p, miR-346, miR-195-5p, miR-103a-3p. Results revealed significant dysregulation miR-103a-3p, highlighting their relevance to SZ pathology. Upregulation miR-137-3p correlated with enhanced cognitive performance, as evidenced improved scores Wisconsin Card Sorting Test (WCST) Trail Making B (TMT-B). Conversely, miR-195-5p miR-346 were strongly associated processing speed, while miR-103a-3p downregulation was linked reduced conceptual flexibility. Cluster analyses demonstrated that expression levels varied significantly based antipsychotic treatment receptor targeting, suggesting regulatory effects medication. Importantly, measured PBMCs, feasibility non-invasive biomarkers. The underscores value miRNAs, offering promising avenue for early detection personalized interventions SZ. Future research should validate these findings across diverse cohorts investigate miRNA-based strategies. By integrating profiling into clinical practice, this provides foundation advancing precision medicine management.

Язык: Английский

Процитировано

0