International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(24), С. 13706 - 13706
Опубликована: Дек. 22, 2024
Single-cell
sequencing
technology
provides
apparent
advantages
in
cell
population
heterogeneity,
allowing
individuals
to
better
comprehend
tissues
and
organs.
Sequencing
is
currently
moving
beyond
the
standard
transcriptome
single-cell
level,
which
likely
bring
new
insights
into
function
of
breast
cells.
In
this
study,
we
examine
primary
types
involved
development,
as
well
achievements
study
scRNA-seq
microenvironment,
stressing
finding
novel
subsets
using
approaches
analyzing
problems
solutions
scRNA-seq.
Furthermore,
are
excited
about
field’s
promising
future.
Biomarker Research,
Год журнала:
2024,
Номер
12(1)
Опубликована: Авг. 31, 2024
Abstract
Malignant
tumors
remain
a
primary
cause
of
human
mortality.
Among
the
various
treatment
modalities
for
neoplasms,
tumor
vaccines
have
consistently
shown
efficacy
and
promising
potential.
These
offer
advantages
such
as
specificity,
safety,
tolerability,
with
mRNA
representing
platforms.
By
introducing
exogenous
mRNAs
encoding
antigens
into
somatic
cells
subsequently
synthesizing
through
gene
expression
systems,
can
effectively
induce
immune
responses.
Katalin
Karikó
Drew
Weissman
were
awarded
2023
Nobel
Prize
in
Physiology
or
Medicine
their
great
contributions
to
vaccine
research.
Compared
traditional
vaccines,
several
advantages,
including
rapid
preparation,
reduced
contamination,
nonintegrability,
high
biodegradability.
Tumor-targeted
therapy
is
an
innovative
modality
that
enables
precise
targeting
cells,
minimizes
damage
normal
tissues,
safe
at
doses,
demonstrates
efficacy.
Currently,
targeted
has
become
important
option
malignant
tumors.
The
application
tumor-targeted
expanding,
numerous
clinical
trials
underway.
We
systematically
outline
delivery
mechanism
by
which
anti-tumor
responses,
describe
current
research
applications
therapy,
forecast
future
development
trends
therapy.
Cells,
Год журнала:
2024,
Номер
13(15), С. 1246 - 1246
Опубликована: Июль 24, 2024
The
triadic
interplay
between
sleep,
immunity,
and
cancer
represents
a
growing
area
of
biomedical
research
with
significant
clinical
implications.
This
review
synthesizes
the
current
knowledge
on
how
sleep
influences
immune
function,
system’s
role
in
dynamics,
direct
connections
patterns
risk.
After
comprehensive
overview
interrelationships
among
these
three
domains,
mechanisms
function
are
described,
detailing
regulates
system,
effects
duration
quality
responses,
underlying
molecular
cellular
mechanisms.
Also,
complex
relationship
immunity
is
explored,
highlighting
prevention
progression,
surveillance,
tumor
microenvironment,
implications
immunodeficiency
modulation
then
presenting
epidemiological
evidence
linking
to
risk,
biological
that
influence
development,
disorders
prognosis.
mediating
highlighted,
proposing
hypothesized
pathways,
summarizing
from
experimental
studies,
evaluating
impact
interventions
outcomes.
concludes
by
discussing
future
directions,
emphasizing
potential
for
sleep-based
treatment,
integration
management
oncology
immunotherapy,
outlining
agenda.
agenda
includes
understanding
sleep–immunity–cancer
interplay,
conducting
studies
assessing
treatment
protocols,
exploring
microenvironment
interactions,
considering
policy
public
health
Through
detailed
examination
interconnected
this
underscores
critical
importance
modulating
outcomes,
advocating
interdisciplinary
strategies
harness
improved
Exploration of Targeted Anti-tumor Therapy,
Год журнала:
2025,
Номер
6
Опубликована: Апрель 26, 2025
Emerging
cancer
immunotherapy
methods,
notably
cytokine-based
ones
that
modify
immune
systems'
inflammatory
reactions
to
tumor
cells,
may
help
slow
gastric
progression.
Cytokines,
tiny
signaling
proteins
communicate
between
or
hinder
growth.
Pro-inflammatory
cytokines
encourage
development,
whereas
antitumor
the
host
reject
cells.
This
study
considers
cytokine-targeted
methods
for
pro-inflammatory
and
responses.
Researchers
want
renew
cells
like
cytotoxic
T
lymphocytes
(CTLs)
natural
killer
(NK)
by
delivering
interleukin-2
(IL-2),
interferons
(IFNs),
necrosis
factor-alpha
(TNF-α)
activate
pathways
combat
tumors.
Since
have
significant
pleiotropic
effects,
their
therapeutic
use
is
difficult
cause
excessive
systemic
inflammation
immunological
suppression.
review
covers
current
advancements
in
synthetic
cytokines,
cytokine-conjugates,
local
administration
of
these
aimed
enhance
index:
increase
potential
kill
while
minimizing
off-target
damage.
The
examines
relationship
microenvironment
(TME),
revealing
role
immunosuppressive
IL-10
transforming
growth
factor-beta
(TGF-β)
promoting
an
immune-evasive
phenotype.
These
results
suggest
inhibitory
pathway
targeting,
therapy
overcome
resistance
mechanisms.
Cytokine-based
immunotherapies
combined
with
checkpoint
inhibitors
are
predicted
change
rebuild
tumor-immune
dynamics,
restoring
immunity.
Comprehensive
data
from
clinical
studies
will
assist
establishing
position
treatments
cancer.
Journal of Cellular and Molecular Medicine,
Год журнала:
2024,
Номер
28(15)
Опубликована: Авг. 1, 2024
Abstract
Breast
cancer
(BC)
is
the
most
commonly
diagnosed
in
women
globally.
Natural
killer
(NK)
cells
play
a
vital
role
tumour
immunosurveillance.
This
study
aimed
to
establish
prognostic
model
using
NK
cell‐related
genes
(NKRGs)
by
integrating
single‐cell
transcriptomic
data
with
machine
learning.
We
identified
44
significantly
expressed
NKRGs
involved
cytokine
and
T
functions.
Using
101
learning
algorithms,
Lasso
+
RSF
showed
highest
predictive
accuracy
nine
key
NKRGs.
explored
cell‐to‐cell
communication
CellChat,
assessed
immune‐related
pathways
microenvironment
gene
set
variation
analysis
ssGSEA,
observed
immune
components
HE
staining.
Additionally,
drug
activity
predictions
potential
therapies,
expression
validation
through
immunohistochemistry
RNA‐seq
confirmed
clinical
applicability
of
The
nomogram
high
concordance
between
predicted
actual
survival,
linking
higher
purity
risk
scores
reduced
score.
NKRG‐based
offers
novel
approach
for
assessment
personalized
treatment
BC,
enhancing
precision
medicine.
Expert Review of Clinical Immunology,
Год журнала:
2024,
Номер
unknown, С. 1 - 15
Опубликована: Сен. 16, 2024
Systemic
sclerosis
(SSc)
is
the
rheumatic
disease
with
highest
individual
mortality
rate
a
detrimental
impact
on
quality
of
life.
Cell-based
therapies
may
offer
new
perspectives
for
this
as
recent
phase
I
trials
support
safety
IV
infusion
allogeneic
mesenchymal
stromal
cells
in
SSc
and
case
reports
highlight
potential
use
Chimeric
Antigen
Receptor
(CAR)-T
targeting
CD19
active
patients
who
have
not
responded
to
conventional
immunosuppressive
therapies.
Advances in systems analysis, software engineering, and high performance computing book series,
Год журнала:
2024,
Номер
unknown, С. 254 - 273
Опубликована: Июнь 28, 2024
This
work
presents
a
holistic
framework
for
automating
automated
guided
vehicles
(AGVs)
in
industrial
settings
by
using
well-positioned
sensors
and
sophisticated
machine
learning
models.
The
AGV
is
put
through
rigorous
testing
along
variety
of
pathways.
It
outfitted
with
such
as
wheel
encoders,
proximity
sensors,
ultrasonic
LIDAR.
Microcontrollers
the
high-speed
electronic
system
enable
real-time
data
processing
decision-making
based
on
sensor
inputs.
For
purpose
anticipating
impediments
maximising
routes,
models
decision
trees
(DT),
artificial
neural
networks
(ANN),
support
vector
machines
(SVM),
random
forests
(RF)
are
developed
assessed.
Experiments
showing
accuracy,
F1
score,
precision,
recall
show
how
well
integrated
is.
prime
example
effective
route
planning,
obstacle
avoidance,
navigation
busy
settings.
Precursor
T-cell
acute
lymphoblastic
leukemia
(Pre-T
ALL)
is
a
malignant
neoplastic
disease
in
which
T-cells
proliferate
the
bone
marrow.
Single-cell
sequencing
technology
could
identify
characteristic
cell
types,
facilitating
study
of
therapeutic
mechanisms
Pre-T
ALL.
