A possible role for epigenetics in cancer initiation

Comptes Rendus Biologies, Год журнала: 2025, Номер 348(G1), С. 43 - 53

Опубликована: Фев. 25, 2025

Cancer is one of the leading causes mortality worldwide. Known since antiquity, its understanding has evolved over time and significantly advanced with new technologies past four decades. initiation currently admitted to be explainable by somatic mutation theory, which postulates that DNA mutations altering function oncogenes tumor suppressor genes initiate cancer. In addition these mutations, epigenetic alterations, heritably change gene expression without sequence, also play a key role. Recent data suggests components regulate all aspects progression, including cancer initiation. These discoveries prompt reevaluation prevention treatment strategies. Le est une des principales de mortalité mondiale. Connu depuis l'Antiquité, sa compréhension évolué au fil du temps et progressé énormément grâce aux nouvelles durant les quatre dernières décennies. L'initiation aujourd'hui expliquée par la théorie somatiques, suggérant que d'ADN altérant fonction d'oncogènes gènes suppresseurs tumeurs initieraient le Outre ces altérations épigénétiques, qui changent l'expression manière héritable sans changement séquence d'ADN, jouent cependant aussi un rôle clé. Des données récentes suggèrent composantes épigénétiques régulent tous progression tumorale, y compris l'initiation cancers. Ces découvertes amènent à revisiter somatiques revoir stratégies prévention traitement

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The Function of Circular RNAs in Regulating Wnt/β-Catenin Signaling: An Innovative Therapeutic Strategy for breast and gynecological Cancers

Pathology - Research and Practice, Год журнала: 2025, Номер unknown, С. 155944 - 155944

Опубликована: Март 1, 2025

Язык: Английский

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Circ_RUSC2 Sequesters miR-661 and Elevates TUSC2 Expression to Suppress Colorectal Cancer Progression

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(7), С. 2937 - 2937

Опубликована: Март 24, 2025

Despite advancements in diagnostic efficiency, colorectal cancer (CRC) remains a leading cause of cancer-related mortality, with increasing incidence rates. Circular RNA (circRNA) is closed-loop, generally stable noncoding that functions as sponge for microRNAs CRC. The purpose this study was to investigate the function and underlying mechanism circ_RUSC2, new circRNA, expression levels miR-661, TUSC2 were assessed using qRT-PCR, Western blot, immunohistochemistry. Functional assays, including CCK-8, Transwell, scratch wound healing, performed evaluate cell proliferation, migration, invasion. pull-down actinomycin D assays used interactions stability. In both CRC cells tissues, miR-661 markedly elevated, while circ_RUSC2 considerably reduced. Poor differentiation, distant metastases, lymph node an advanced stage all strongly correlated either overexpression or downregulation. more compared its linear RUSC2 mRNA. invasion, proliferation suppressed by ectopic expression; inhibitory effect restored mimic. Circ_RUSC2 served miR-661's sponge. counteracted effects which stimulated At post-transcriptional level, controlled cells. comparison negative control, reduced, half-life shortened methyltransferase-like 3 (METTL3) knockdown. cytoplasmic circRNA. inhibits malignant phenotypes via miR-661/TUSC2 axis. onset progression are linked downregulation Circ_RUSC2. might become through N6-methyladenosine (m6A) methylation regulated METTL3. According our research, be biomarker treatment target

Язык: Английский

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circRNA/TLR interaction: key players in immune regulation and autoimmune diseases

Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2025, Номер unknown

Опубликована: Май 6, 2025

Язык: Английский

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