ARAP1-AS1: a novel long non-coding RNA with a vital regulatory role in human cancer development DOI Creative Commons
Jialing Wang, Hongliang Luo, Lu Yang

и другие.

Cancer Cell International, Год журнала: 2024, Номер 24(1)

Опубликована: Авг. 1, 2024

Long non-coding RNAs (lncRNAs) have garnered significant attention in biomedical research due to their pivotal roles gene expression regulation and association with various human diseases. Among these lncRNAs, ArfGAP With RhoGAP Domain, Ankyrin Repeat, And PH Domain 1 - Antisense RNA (ARAP1-AS1) has recently emerged as an novel oncogenic player. ARAP1-AS1 is prominently overexpressed numerous solid tumors wields influence by modulating signaling pathways. This regulatory impact realized through dual mechanisms, involving both competitive interactions microRNAs direct protein binding. assumes important role driving tumorigenesis malignant tumor progression, affecting biological characteristics such expansion metastasis. paper provides a concise review of the discuss its potential clinical applications biomarker therapeutic target. We also address existing knowledge gaps suggest avenues for future research. serves prototypical example within burgeoning field lncRNA studies, offering insights into broader landscape molecules. investigation enhances our comprehension complex mechanisms that govern progression cancer.

Язык: Английский

ARAP1-AS1: a novel long non-coding RNA with a vital regulatory role in human cancer development DOI Creative Commons
Jialing Wang, Hongliang Luo, Lu Yang

и другие.

Cancer Cell International, Год журнала: 2024, Номер 24(1)

Опубликована: Авг. 1, 2024

Long non-coding RNAs (lncRNAs) have garnered significant attention in biomedical research due to their pivotal roles gene expression regulation and association with various human diseases. Among these lncRNAs, ArfGAP With RhoGAP Domain, Ankyrin Repeat, And PH Domain 1 - Antisense RNA (ARAP1-AS1) has recently emerged as an novel oncogenic player. ARAP1-AS1 is prominently overexpressed numerous solid tumors wields influence by modulating signaling pathways. This regulatory impact realized through dual mechanisms, involving both competitive interactions microRNAs direct protein binding. assumes important role driving tumorigenesis malignant tumor progression, affecting biological characteristics such expansion metastasis. paper provides a concise review of the discuss its potential clinical applications biomarker therapeutic target. We also address existing knowledge gaps suggest avenues for future research. serves prototypical example within burgeoning field lncRNA studies, offering insights into broader landscape molecules. investigation enhances our comprehension complex mechanisms that govern progression cancer.

Язык: Английский

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