Stem Cell Research & Therapy, Год журнала: 2025, Номер 16(1)

Опубликована: Май 6, 2025

Elucidating the molecular mechanisms underlying orthopedic diseases is crucial for guiding therapeutic strategies and developing innovative interventions. N6-methyladenosine (m6A)-an epitranscriptomic modification-has emerged as a key regulator of cellular fate tissue homeostasis. Specifically, m6A plays pivotal role in several RNA biological processes such precursor splicing, 3'-end processing, nuclear export, translation, stability. Recent advancements indicate that methylation regulates stem cell proliferation osteogenic differentiation by modulating various signaling pathways. Extensive research has shown abnormalities contribute significantly to onset progression osteoporosis (OP), osteoarthritis (OA), rheumatoid arthritis (RA), bone tumors. This review aims summarize proteases involved their functions. The detailed which marrow mesenchymal cells (BMSCs) through direct indirect ways are also discussed, with focus on specific Finally, this analyzes roles modification development multiple diseases, offering comprehensive understanding pathophysiology these conditions proposing new directions targets treatment strategies.

Язык: Английский