Pathology - Research and Practice, Год журнала: 2024, Номер 263, С. 155641 - 155641
Опубликована: Окт. 3, 2024
Язык: Английский
Molecular Biology Reports, Год журнала: 2025, Номер 52(1)
Опубликована: Янв. 21, 2025
Язык: Английский
Процитировано
2
Clinica Chimica Acta, Год журнала: 2024, Номер 565, С. 119983 - 119983
Опубликована: Окт. 3, 2024
Язык: Английский
Процитировано
15
Pathology - Research and Practice, Год журнала: 2024, Номер 262, С. 155570 - 155570
Опубликована: Авг. 29, 2024
Язык: Английский
Процитировано
10
Non-coding RNA Research, Год журнала: 2024, Номер 9(4), С. 1222 - 1234
Опубликована: Май 20, 2024
Ferroptosis, a form of regulated cell death, has emerged as crucial process in diverse pathophysiological states, encompassing cancer, neurodegenerative ailments, and ischemia-reperfusion injury. The glutathione (GSH)-dependent lipid peroxidation pathway, chiefly governed by peroxidase 4 (GPX4), assumes an essential part driving ferroptosis. GPX4, the principal orchestrator ferroptosis, garnered significant attention across cardiovascular, neuroscience domains over past decade. Noteworthy investigations have elucidated indispensable functions ferroptosis numerous diseases, including tumorigenesis, wherein robust within cells can impede tumor advancement. Recent research underscored complex regulatory role non-coding RNAs (ncRNAs) regulating GSH-GPX4 network, thus influencing cellular susceptibility to This exhaustive review endeavors probe into multifaceted processes which ncRNAs control network Specifically, we delve miRNAs, lncRNAs, circRNAs GPX4 expression impacting Moreover, discuss clinical implications dysregulated interactions between several conditions, underscoring their capacity viable targets for therapeutic intervention. Additionally, explores emerging strategies aimed at targeting modulate pathway manipulate advantage. A comprehensive understanding these intricate networks furnishes insights innovative avenues diseases associated with perturbed thereby laying groundwork interventions ferroptosis-related pathological conditions.
Язык: Английский
Процитировано
8
Radiation Oncology, Год журнала: 2024, Номер 19(1)
Опубликована: Июнь 26, 2024
Abstract Background At present, it has been found that many patients have acquired resistance to radiotherapy, which greatly reduces the effect of radiotherapy and further affects prognosis. CircRNAs is involved in regulation radiosensitivity kinds tumor cells. Therefore, main purpose this study explore regulatory CircRNA_101491 on ESCC its related mechanism. Methods We established radiation-resistant cell line (KYSE150R cell) by gradient dose method, tested difference KYSE150 between KYSE150R parent vitro. Then, after knocking down expression CircRNA_101491, a series vitro experiments were conducted verify effects phenotype cells, analyzed In addition, we also used model transplanted nude mice investigate vivo. Results According experiments, confirmed cells lost epithelial obtained interstitial cell-like phenotype, was highly expressed will lift inhibition miR-125a-5p, then reverse process EMT, accelerate apoptosis, thus play role radiosensitization. The vivo experiment showed could enhance ESCC. Conclusion conclusion, interfering with can relieve
Язык: Английский
Процитировано
2
Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2024, Номер unknown
Опубликована: Авг. 21, 2024
Язык: Английский
Процитировано
2
Brain Research, Год журнала: 2024, Номер 1841, С. 149089 - 149089
Опубликована: Июнь 15, 2024
Язык: Английский
Процитировано
1
Current Drug Targets, Год журнала: 2024, Номер 25(13), С. 866 - 884
Опубликована: Сен. 2, 2024
An aneurysm is an abnormal enlargement or bulging of the wall a blood vessel. Most often, aneurysms occur in large vessels - aorta (Thoracic Aortic Aneurysm (TAA) and Abdominal (AAA) brain (Intracranial (IA)). Despite presence significant differences pathogenesis development progression IA TAA/AAA, there are also similarities. For instance, both have been shown to be strongly influenced by shear stress, inflammatory processes, enzymatic destruction elastic lamellae extracellular matrix (ECM) proteins vascular wall. Moreover, although TAA predominantly considered arteriopathies with different pathological mechanisms, they share risk factors AAA, such as hypertension smoking. However, need for more in- -depth study key elements that may influence formation particular find ways therapeutic intervention search diagnostic tool. Today, it known disruption gene expression one main mechanisms contribute aneurysms. At same time, growing evidence suggests aberrant epigenetic regulation function related genesis Although much has studied protein-coding genes, circular RNAs (circRNAs), relatively new rapidly evolving family transcripts, recently received scientific attention. CircRNAs regulate through sponging microRNAs (miRNAs) can used targets biomarkers. Increasing implicated circRNAs multiple cardiovascular diseases, including mechanism dysregulation certain remains studied. The discovery advanced our understanding latest mode miRNAs/target genes TAA/AAA. aim this compare profiles similar effects on
Язык: Английский
Процитировано
0
Pathology - Research and Practice, Год журнала: 2024, Номер 263, С. 155641 - 155641
Опубликована: Окт. 3, 2024
Язык: Английский
Процитировано
0