SQYC formula improves the efficacy of PD-1 monoclonal antibodies in MSS colorectal cancer by regulating dendritic cell mitophagy via the PINK1-Parkin pathway
Phytomedicine,
Год журнала:
2025,
Номер
138, С. 156388 - 156388
Опубликована: Янв. 11, 2025
Язык: Английский
The Role of Proteomics and Genomics in the Development of Colorectal Cancer Diagnostic Tools and Potential New Treatments
ACS Pharmacology & Translational Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 10, 2025
The
complex
molecular
mechanisms
involving
genetic
and
epigenetic
modifications
contribute
to
colorectal
cancer
(CRC),
which
remains
a
significant
threat
world
health.
This
review
elucidates
the
role
of
proteomics
genomics
in
progression,
diagnosis,
treatment
cancers.
All
potential
key
pathways
involved
CRC,
including
WNT,
MAPK,
PI3K,
TGF-β
pathways,
are
reviewed
with
systematic
analysis,
concluding
their
involvement
tumorigenesis
therapeutic
resistance.
Emerging
next-generation
sequencing
technologies
revealed
critical
mutations
that
relevant
CRC
development.
Proteomics
has
contributed
identifying
biomarkers
post-translational
hold
promise
for
targeted
therapies.
Recent
technological
advances
have
provided
functional
insights
into
protein
signaling
networks
through
mass
spectrometry
integrated
proteogenomic
approaches.
work
emphasizes
biomarker-driven
translational
efforts
integrate
genomic
expression
profiles
refine
personalized
treatments.
application
innovations
liquid
biopsy
computational
biology
advocates
precision
medicine
paths
improve
outcomes
CRC.
Now,
pharmacoproteomics
offers
novel
domains
drug
discovery
resistance
management
serves
as
foundation
comprehensive
paradigms.
Язык: Английский
Global Research Trends and Hotspots in the Role of Cholesterol in Colorectal Cancer: A Bibliometric Analysis
Human Mutation,
Год журнала:
2025,
Номер
2025(1)
Опубликована: Янв. 1, 2025
Background:
Cholesterol
metabolism
is
important
in
colorectal
cancer
(CRC)
pathogenesis,
influencing
tumorigenesis
and
therapeutic
responses.
Despite
extensive
research,
fragmented
insights
a
lack
of
systematic
analysis
hinder
the
identification
global
trends,
collaboration
networks,
emerging
hotspots
this
rapidly
evolving
field.
Methods:
A
bibliometric
1532
publications
(2003–2024)
from
Web
Science
Core
Collection
was
conducted
using
VOSviewer,
CiteSpace,
R
software.
Metrics
included
publication
country/institution
contributions,
author
journal
influence,
keyword
co‐occurrence,
citation
bursts.
Results:
Global
exhibited
exponential
growth,
peaking
at
114
2024.
The
United
States
(347
articles,
17,613
citations)
China
(316
articles)
dominated
research
output,
yet
institutional
remained
limited.
Key
journals
PLOS
One
Cancer
Research
.
Keyword
evolution
shifted
“physical
activity”
“carcinogenesis”
to
“cholesterol
metabolism,”
“gut
microbiota,”
“nanomedicine.”
Statins
showed
preventive
potential
but
raised
concerns
with
prolonged
use.
Mechanistic
highlighted
nanoparticle‐driven
therapies
as
promising
strategies
enhance
chemosensitivity
reverse
immunosuppression.
Conclusion:
This
inaugural
comprehensive
delineates
current
landscape
cholesterol
CRC,
particular
emphasis
on
elucidating
metabolic
reprogramming
mechanisms
fostering
cross‐disciplinary
convergence.
Future
priorities
include
validating
statins’
efficacy
via
randomized
trials,
leveraging
multiomics
for
personalized
therapies,
address
geographic
disparities
translational
challenges.
Язык: Английский