Hypoxia-inducible factor and cellular senescence in pulmonary aging and disease

Biogerontology, Год журнала: 2025, Номер 26(2)

Опубликована: Фев. 26, 2025

Abstract Cellular senescence and hypoxia-inducible factor (HIF) signaling are crucial in pulmonary aging age-related lung diseases such as chronic obstructive disease idiopathic fibrosis cancer. HIF plays a pivotal role cellular adaptation to hypoxia, regulating processes like angiogenesis, metabolism, inflammation. Meanwhile, leads irreversible cell cycle arrest, triggering the senescence-associated secretory phenotype which contributes inflammation, tissue remodeling, fibrosis. Dysregulation of these pathways accelerates progression by promoting oxidative stress, mitochondrial dysfunction, epigenetic alterations. Recent studies indicate that interact at multiple levels, where can both induce suppress senescence, depending on conditions. While transient activation supports repair stress resistance, dysregulation exacerbates pathologies. Furthermore, emerging evidence suggests targeting could offer new therapeutic strategies mitigate diseases. This review explores intricate crosstalk between mechanisms, shedding light how their interplay influences progression. Additionally, we discuss potential interventions, including senolytic therapies modulators, enhance health longevity.

Язык: Английский

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Genome-wide identification of the TGF-β superfamily and their expression in the Chinese mitten crab Eriocheir sinensis

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Апрель 13, 2025

Transforming growth factor-β superfamily genes are multifunctional cytokines that play central roles in the regulation of cell proliferation, differentiation, apoptosis, adhesion, and migration. Identifying TGF-β crabs could provide a basis for elucidating genetic regulatory mechanism growth, development, sex differentiation environmental adaptation. To understand complexity evolution Chinese mitten crab Eriocheir sinensis, this study comprehensively systematically analysed genome E. sinensis. A total 9 have been identified, including EsBMP2, EsBMP3, EsBMP7, EsBMP10, EsBMP15, EsGDF8, EsUnivin, EsINHB EsINHBB. wide variation number motifs CDSs was found among different subfamilies. The expression EsBMP2 EsBMP7 suggested these may be main controlling embryonic development EsBMP10 very highly expressed gills. presented patterns during limb regeneration molting. In addition, gene family also responds to stresses, nanoplastic stress, cadmium air exposure, high-salinity which provides new perspective understanding strong tolerance adaptability stress. our knowledge, is first genome-wide investigation crabs. This identified sequence structure, phylogenetic relationship, profiles crab, above results lay foundation further biological functions family.

Язык: Английский

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Caspase-independent cell death in lung cancer: from mechanisms to clinical applications

Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2025, Номер unknown

Опубликована: Апрель 21, 2025

Abstract Caspase-independent cell death (CICD) has recently become a very important mechanism in lung cancer, particular, to overcome critical failure apoptotic that is common disease progression and treatment failures. The pathways involved CICD span from necroptosis, ferroptosis, mitochondrial dysfunction, autophagy-mediated death. Its potential therapeutic applications have been highlighted. Glutathione peroxidase 4 (GPX4) inhibition-driven ferroptosis drug resistance non-small cancer (NSCLC). In addition, necroptosis involving RIPK1 RIPK3 causes tumor modulation of immune responses the microenvironment (TME). Mitochondrial are for through metabolic redox homeostasis. Ferroptosis amplified by reactive oxygen species (ROS) lipid peroxidation cells, depolarization induces oxidative stress leads mitochondria-mediated autophagy, or mitophagy, results clearance damaged organelles under conditions, while this function also linked when dysregulated. role autophagy regulated ATG proteins PI3K/AKT/mTOR pathway dual: suppress sensitize cells therapy. A promising approach enhancing outcomes involves targeting mechanisms CICD, including inducing SLC7A11 inhibition, modulating ROS generation, combining inhibition with chemotherapy. Here, we review molecular underpinnings particularly on their transform treatment.

Язык: Английский

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The Impact of NF-κB on Inflammatory and Angiogenic Processes in Age-Related Macular Degeneration

Experimental Eye Research, Год журнала: 2024, Номер 248, С. 110111 - 110111

Опубликована: Сен. 24, 2024

Язык: Английский

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Circular RNAs and the JAK/STAT pathway: New frontiers in cancer therapeutics

Pathology - Research and Practice, Год журнала: 2024, Номер 260, С. 155408 - 155408

Опубликована: Июнь 13, 2024

Язык: Английский

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Reprogramming Tumor-Associated Macrophages: The Role of MEK-STAT3 Inhibition in Lung Cancer

Pathology - Research and Practice, Год журнала: 2024, Номер 265, С. 155748 - 155748

Опубликована: Ноя. 28, 2024

Язык: Английский

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The Relationship of Heavy Metals With Lung Cancer: A Systematic Review

Procedia of Engineering and Life Science, Год журнала: 2024, Номер 7, С. 755 - 759

Опубликована: Авг. 20, 2024

General Background: Heavy metals such as lead, cadmium, nickel, and copper are known environmental pollutants with established toxic effects on human health. Specific These elements have been identified significant contributors to various diseases, emerging evidence suggesting their role in promoting cancer, particularly lung cancer. Knowledge Gap: Although numerous studies investigated the relationship between heavy a comprehensive understanding of impact metal concentrations cancer development progression remains underexplored. Aims: This systematic review aims consolidate analyze existing literature exposure focusing different biological samples plasma, urine, nails, hair. Results: The consistent linking increased levels higher risks Studies highlighted like chromium, nickel not only growth but also impacting efficacy treatment. findings suggest that these metals, often from industrial sources, is critical risk factor for Novelty: uniquely synthesizes data diverse samples, providing holistic view how influences Implications: study underscores importance monitoring regulating reduce incidence It emphasizes need further research develop targeted strategies mitigating associated metal-induced carcinogenesis. Highlights: cadmium increase significantly. Diverse (plasma, urine) reveal metals' Regulating key preventing Keywords: Metals, Lung Cancer, Cadmium, Carcinogenesis, Toxic Exposure

Язык: Английский

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Determining heavy metal in road dust and human health assessment in Aizawl, Mizoram

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Ноя. 6, 2024

The study aims to assess the concentrations of heavy metals in road dust from different land uses Aizawl, Mizoram, by implementing a methodology that includes descriptive statistics (mean, median, and standard deviation), one-way ANOVA, Pearson correlation coefficient. Enrichment contamination factors were also determined identify sources level pollution area. health risks for children adults assessed based on established guidelines. From study, ranged as follows: Cr (18.19 36.28 mg/kg), Pb (20.64 27.12 Cd (-1 0.06 Ni (32.32 47.91 Cu (-0.51 32.49 Zn (30.80 119.84 mg/kg). highest concentration was found agricultural area (47.91 possibly due jhum cultivation practices. When compared with background values, levels lower, while Pb, Ni, exceeded values 94.66%, 41.47%, 228.54%, respectively, indicating anthropogenic activities. A ANOVA analysis showed significant difference metal across various use areas. Except ecological risk assessment indicated low risk. associated non-carcinogenic effects humans, especially children, other elements within safe levels. Proper management safety measures still needed improve environmental impact individuals living

Язык: Английский

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Study on soil heavy metal contamination and its remediation using lignin-based adsorbents: A review

Environmental Technology & Innovation, Год журнала: 2024, Номер unknown, С. 103958 - 103958

Опубликована: Дек. 1, 2024

Язык: Английский

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