Pathology - Research and Practice, Год журнала: 2024, Номер 264, С. 155708 - 155708
Опубликована: Ноя. 6, 2024
Язык: Английский
Gene, Год журнала: 2025, Номер unknown, С. 149217 - 149217
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(3), С. 1377 - 1377
Опубликована: Фев. 6, 2025
The interplay between long noncoding RNAs (lncRNAs) and microRNAs (miRNAs) is crucial in the epigenetic regulation of mRNA protein expression, impacting development progression a plethora human diseases, such as cancer, cardiovascular disease, inflammatory-associated viral infection. Among many lncRNAs, growth arrest-specific 5 (GAS5) has garnered substantial attention for its evident role significant biological processes proliferation, differentiation, senescence, apoptosis. Through miRNA-mediated signaling pathways, GAS5 modulates disease cell-type-specific manner, typically by influencing proteins involved inflammation cell death. While recognized tumor suppressor recent reports highlight broader regulatory capacity non-cancerous diseases. Its modulation expression through GAS5/miRNA network been shown to both mitigate exacerbate depending on specific context. Furthermore, therapeutic potential manipulation, via knockdown or overexpression, offers promising avenues targeted interventions across This review explores dualistic impacts conditions infections, inflammatory disorders. evaluation current evidence, we aim provide insight into GAS5's functions implications future research development.
Язык: Английский
Процитировано
0
Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2025, Номер unknown
Опубликована: Март 17, 2025
Язык: Английский
Процитировано
0
Biomolecules, Год журнала: 2025, Номер 15(3), С. 454 - 454
Опубликована: Март 20, 2025
Triple-negative breast cancer (TNBC) is a highly heterogeneous and aggressive subtype of that faces therapeutic challenges due to shortage effective targeted therapies. The complex biology TNBC renders its clinical management fraught with difficulties, especially regarding the immune microenvironment tumor. In recent years, long non-coding RNAs (lncRNAs) have been recognized as important gene regulators key roles in tumor development microenvironmental regulation. Previous studies shown lncRNAs play TNBC, including regulation escape function tumor-infiltrating cells. However, despite increasing research on lncRNAs, there are still many unanswered questions, such their specific mechanism action how effectively utilize them targets. Therefore, aim this study was review mechanisms microenvironment, explore regulatory cell infiltration, prospects potential By integrating latest results, aims provide new ideas directions for future treatment.
Язык: Английский
Процитировано
0
Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2025, Номер unknown
Опубликована: Март 22, 2025
Язык: Английский
Процитировано
0
Regenerative Therapy, Год журнала: 2025, Номер 29, С. 352 - 363
Опубликована: Апрель 8, 2025
Язык: Английский
Процитировано
0
Cells, Год журнала: 2025, Номер 14(7), С. 555 - 555
Опубликована: Апрель 7, 2025
Long noncoding RNAs (lncRNAs) are RNA molecules exceeding 200 nucleotides that do not encode proteins yet play critical roles in regulating gene expression at multiple levels, such as chromatin modification and transcription. These significantly engaged cancer progression, development, metastasis, chemoresistance. However, the function of lncRNAs epithelial ovarian (EOC) has been thoroughly studied. EOC remains challenging due to its complex molecular pathogenesis, characterized by genetic epigenetic alterations. Emerging evidence suggests lncRNAs, XIST, H19, NEAT1, MALAT1, involved modulating signaling pathways, influencing processes like cell proliferation, invasion, migration, Despite extensive research, precise mechanism acting pathogenesis treatment resistance still needs be fully understood, highlighting need for further studies. This review aims provide an updated overview current understanding EOC, emphasizing their potential biomarkers therapeutic targets. We point out gaps knowledge regarding lncRNAs’ influence on (EOC), deliberating new possible research areas.
Язык: Английский
Процитировано
0
Journal of Cancer, Год журнала: 2024, Номер 15(17), С. 5577 - 5593
Опубликована: Янв. 1, 2024
The occurrence and development of hepatocellular carcinoma (HCC) are closely related to abnormal apoptosis. Brf1 is highly expressed in HCC has clinical prognostic value. Here, attenuation Brf1-induced apoptosis was found, the mechanism explored. In study, general bioinformatics data for were obtained from Human Protein Atlas (HPA). Analyses value performed with Xiantao Academic web server using R software. basic GTEx database TCGA database. conditional knockout mice by repeated mating C57BL/6 Brf1LoxP/LoxP NS5A-alb-Cre-ERT2 verified genotyping. Liver function measurements, hematoxylin eosin staining (HE), immunohistochemistry (IHC) explore cause mouse death after knockout. knockdown cell model generated lentiviral vector-based shRNA transduction. Cell proliferation assays, plate colony formation anchorage-independent assays subcutaneous tumor models used evaluate progression HCC. Western blot (WB) analysis, flow cytometry, TUNEL detect DNA sequencing, transcriptomics, proteomics analyses carried out antiapoptotic Brf1. We found that had led liver failure hepatocyte mice. Downregulation slowed proliferation, growth, growth increased sensitivity cells induced chemotherapy drugs. expression positively gene Bcl-2. transcriptomics consistently showed energy metabolism played an important role function, protein-protein interaction primary mode, organelles such as mitochondria main sites. Conclusions, downregulation inhibits inducing Energy plays function. These results provide a scientific basis combating
Язык: Английский
Процитировано
1
International Journal of Biological Macromolecules, Год журнала: 2024, Номер 287, С. 138589 - 138589
Опубликована: Дек. 9, 2024
Breast cancer (BC) is one of the common female cancers and it characterized by considerable problems regarding its development therapy. Long non-coding RNAs (lncRNAs) have been identified as significant modulators in BC development, especially, tumorigenicity chemoresistance. We therefore endeavor to present an up-to-date understanding lncRNAs their impact on progression treatment, concerning molecular processes, treatment options, use a therapeutic opportunity. LncRNAs are novel regulators genes that cause resistance directly functioning both coding patients, but little known about mechanisms actions. Thus, additional study required deeper modes action possible roles disease. This aims investigate functions BC, with particular attention role tumorigenesis, drug mechanisms, targets. will help identify targets improve effectiveness treatment.
Язык: Английский
Процитировано
1
Pathology - Research and Practice, Год журнала: 2024, Номер 264, С. 155708 - 155708
Опубликована: Ноя. 6, 2024
Язык: Английский
Процитировано
0