Progress on long non-coding RNAs in calcific aortic valve disease DOI Creative Commons
Yan Shen, Jiahui Li, Zehao Zhao

и другие.

Frontiers in Cardiovascular Medicine, Год журнала: 2025, Номер 12

Опубликована: Янв. 17, 2025

Calcific aortic valve disease (CAVD) is a common cardiovascular condition in the elderly population. The valve, influenced by factors such as endothelial dysfunction, inflammation, oxidative stress, lipid metabolism disorders, calcium deposition, and extracellular matrix remodeling, undergoes fibrosis calcification, ultimately leading to stenosis. In recent years, long non-coding RNAs (lncRNAs) have emerged significant regulators of gene expression, playing crucial roles occurrence progression various diseases. Research has shown that lncRNAs participate pathological process underlying CAVD regulating osteogenic differentiation inflammatory response interstitial cells. Specifically, lncRNAs, H19, MALAT1, TUG1, are closely associated with CAVD. Some can act miRNA sponges, form complex regulatory networks, modulate expression calcification-related genes. brief, this review discusses mechanisms potential therapeutic targets

Язык: Английский

Progress on long non-coding RNAs in calcific aortic valve disease DOI Creative Commons
Yan Shen, Jiahui Li, Zehao Zhao

и другие.

Frontiers in Cardiovascular Medicine, Год журнала: 2025, Номер 12

Опубликована: Янв. 17, 2025

Calcific aortic valve disease (CAVD) is a common cardiovascular condition in the elderly population. The valve, influenced by factors such as endothelial dysfunction, inflammation, oxidative stress, lipid metabolism disorders, calcium deposition, and extracellular matrix remodeling, undergoes fibrosis calcification, ultimately leading to stenosis. In recent years, long non-coding RNAs (lncRNAs) have emerged significant regulators of gene expression, playing crucial roles occurrence progression various diseases. Research has shown that lncRNAs participate pathological process underlying CAVD regulating osteogenic differentiation inflammatory response interstitial cells. Specifically, lncRNAs, H19, MALAT1, TUG1, are closely associated with CAVD. Some can act miRNA sponges, form complex regulatory networks, modulate expression calcification-related genes. brief, this review discusses mechanisms potential therapeutic targets

Язык: Английский

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