Research progress on ferroptosis and PARP inhibitors in ovarian cancer: action mechanisms and resistance mechanisms

Frontiers in Pharmacology, Год журнала: 2025, Номер 16

Опубликована: Апрель 24, 2025

Ovarian cancer, a gynecologic malignancy with high mortality rates, faces persistent therapeutic challenges due to acquired resistance and frequent recurrence conventional therapies. While poly (ADP-ribose) polymerase (PARP) inhibitors have primarily transformed clinical outcomes through the synthetic lethality mechanism, their long-term efficacy remains constrained by resistance. Ferroptosis, novel programmed cell death modality characterized iron-dependent lipid peroxidation, has emerged as promising frontier in oncology. This review is first summarize mechanisms of action associated both ferroptosis PARP ovarian cancer.

Язык: Английский

Ferroptosis and Low-Grade Glioma: The Breakthrough Potential of NUAK2

Free Radical Biology and Medicine, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Язык: Английский