Journal of Pharmaceutical Analysis,
Год журнала:
2024,
Номер
14(6), С. 100930 - 100930
Опубликована: Янв. 3, 2024
Non-communicable
diseases
(NCDs),
including
cardiovascular
diseases,
cancer,
metabolic
and
skeletal
pose
significant
challenges
to
public
health
worldwide.
The
complex
pathogenesis
of
these
is
closely
linked
oxidative
stress
inflammatory
damage.
Nuclear
factor
erythroid
2-related
2
(Nrf2),
a
critical
transcription
factor,
plays
an
important
role
in
regulating
antioxidant
anti-inflammatory
responses
protect
the
cells
from
damage
inflammation-mediated
injury.
Therefore,
Nrf2-targeting
therapies
hold
promise
for
preventing
treating
NCDs.
Quercetin
(Que)
widely
available
flavonoid
that
has
properties.
It
modulates
Nrf2
signaling
pathway
ameliorate
inflammation.
Que
mitochondrial
function,
apoptosis,
autophagy,
cell
biomarkers
regulate
inflammation,
highlighting
its
efficacy
as
therapeutic
agent
against
Here,
we
discussed,
first
time,
close
association
between
NCD
pathway,
involved
neurodegenerative
disease,
cancers,
organ
damage,
bone
Furthermore,
reviewed
availability,
pharmacokinetics,
pharmaceutics,
applications
In
addition,
focused
on
prospects
clinical
use.
represents
promising
candidate
treatment
NCDs
due
Behavioral and Brain Functions,
Год журнала:
2025,
Номер
21(1)
Опубликована: Янв. 8, 2025
Alzheimer's
disease
(AD)
is
a
prevalent
and
progressive
neurodegenerative
disorder
that
the
leading
cause
of
dementia.
The
underlying
mechanisms
AD
have
not
yet
been
completely
explored.
Neuroinflammation,
an
inflammatory
response
mediated
by
certain
mediators,
has
exhibited
to
play
crucial
role
in
pathogenesis
AD.
Additionally,
disruption
gut
microbiota
found
be
associated
with
AD,
fecal
transplantation
(FMT)
emerged
as
potential
therapeutic
approach.
However,
precise
mechanism
FMT
treatment
remains
elusive.
In
this
study,
was
performed
transplanting
from
healthy
wild-type
mice
into
APP/PS1
(APPswe,
PSEN1dE9)
assess
effectiveness
mitigating
AD-associated
inflammation
reveal
its
action.
results
demonstrated
improved
cognitive
function
reduced
expression
levels
factors
regulating
TLR4/MyD88/NF-κB
signaling
pathway
mice,
which
accompanied
restoration
microbial
dysbiosis.
These
findings
suggest
ameliorate
symptoms
delay
progression
mice.
Journal of Translational Medicine,
Год журнала:
2024,
Номер
22(1)
Опубликована: Май 3, 2024
Abstract
Background
The
Mediterranean
diet
(MedDiet)
is
a
widely
studied
dietary
pattern
reflecting
the
culinary
traditions
of
regions.
High
adherence
to
MedDiet
correlates
with
reduced
blood
pressure
and
lower
cardiovascular
disease
(CVD)
incidence
mortality.
Furthermore,
microbiota,
influenced
by
diet,
plays
crucial
role
in
health,
dysbiosis
CVD
patients
suggests
possible
beneficial
effects
microbiota
modulation
on
pressure.
MedDiet,
rich
fiber
polyphenols,
shapes
distinct
associated
higher
biodiversity
positive
health
effects.
review
aims
describe
how
various
components
impact
gut
influencing
dynamics.
Main
body
promotes
regulation
through
its
components.
For
instance,
whole
grains
promote
healthy
given
that
they
act
as
substrates
leading
production
short-chain
fatty
acids
(SCFAs)
can
modulate
immune
response,
preserve
barrier
integrity,
regulate
energy
metabolism.
Other
including
olive
oil,
fuits,
vegetables,
red
wine,
fish,
lean
proteins,
have
also
been
regulation.
Conclusion
approach
offers
several
benefits
terms
management
risk
factors,
hypertension.
intake
favorable
environment,
which,
turn,
has
shown
aids
other
physiological
processes
like
Antioxidants,
Год журнала:
2025,
Номер
14(1), С. 67 - 67
Опубликована: Янв. 8, 2025
Background:
In
vitro
findings
on
the
biological
functions
of
Lycium
barbarum
flavonoids
(LBFs)
as
feed
additives
are
limited.
This
study
aimed
to
explore
effects
different
concentrations
LBFs
growth
performance,
immune
function,
intestinal
barrier,
and
antioxidant
capacity
meat
ducks.
A
total
240
one-day-old
male
ducks
were
randomly
allocated
four
groups,
each
receiving
a
basal
diet
supplemented
with
0
(control),
250,
500,
or
1000
mg/kg
for
42
d.
Results:
The
results
showed
that
dietary
supplementation
500
resulted
in
significant
increase
average
daily
intake,
body
weight,
gain,
conversion
ratio.
Dietary
decreases
serum
levels
D-lactic
acid
lipopolysaccharide.
significantly
decreased
diamine
oxidase
activity
enhanced
activities
catalase,
capacity,
glutathione
peroxidase
jejunal
mucosa,
well
superoxide
dismutase
content
ileal
while
lowering
malondialdehyde
mucosa.
up-regulated
mRNA
expression
genes
associated
barrier
function
protein
these
genes,
led
reduction
pro-apoptotic
inflammatory-related
genes.
Conclusions:
addition
improved
response,
ducks,
which
may
be
closely
activation
Nrf2
signaling
pathway
inhibition
NF-κB
pathway.
optimal
inclusion
level
was
mg/kg.
Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology,
Год журнала:
2025,
Номер
16(1)
Опубликована: Фев. 19, 2025
Abstract
Background
Organic
selenium
(Se)
has
gained
recognition
in
poultry
nutrition
as
a
feed
additive
to
boost
production
and
Se
deposition
eggs
tissues,
owing
its
high
bioavailability,
efficient
tissue
accumulation
minimal
toxicity.
Selenium-enriched
yeast
(SeY)
is
well-established
source,
while
selenium-enriched
lactobacilli
(SeL),
newer
alternative,
offers
the
added
benefits
of
probiotics.
This
study
examined
effects
SeY
SeL
on
egg
quality,
antioxidant
capacity,
deposition,
gut
health
laying
hens.
After
two-week
pre-treatment
with
Se-deficient
diet
(SeD),
450
Hy-Line
Brown
hens
(30-week-old)
were
assigned
into
five
dietary
groups
six
replicates
15
each.
The
included
SeD,
SeD
supplemented
1.5
mg
Se/kg
from
(SeY15),
or
1.5,
3.0,
6.0
(SeL15,
SeL30,
SeL60).
feeding
trial
lasted
for
12
weeks.
Results
SeY15
SeL15
improved
feed-to-egg
ratio
(
P
<
0.05)
latter
stages.
Haugh
units
significantly
increased
SeL30
groups,
darker
yolk
color
was
observed
SeY15,
SeL15,
SeL60
groups.
All
Se-supplemented
diets
content
whole
eggs,
albumen,
0.05),
showed
dose-dependent
effect.
Antioxidant
enzyme
activities
increased,
MDA
decreased
serum
showing
highest
GSH-Px
levels
0.05).
alkaline
phosphatase
aspartate
transaminase,
distorted
liver
architecture
Se-diets
reduced
concentrations
reactive
oxygen
species
(ROS)
ileum
ileal
villus
height-to-crypt
depth
and/or
up-regulated
TXNRD1
SEPHS1
mRNA
down-regulating
SCLY
expression
liver.
altered
microbiota
by
increasing
both
beneficial
pathogenic
bacteria,
whereas
predominantly
boosted
bacteria.
Conclusion
integrates
properties
organic
probiotic
health,
resulting
performance-enhancing
effect
comparable
that
SeY.
However,
level
(6.0
Se/kg)
compromised
productivity
metabolic
functions
enhancing
deposition.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(8), С. 6888 - 6888
Опубликована: Апрель 7, 2023
Major
depressive
disorder
is
one
of
the
most
common
mental
illnesses
that
highly
impairs
quality
life.
Pharmacological
interventions
are
mainly
focused
on
altered
monoamine
neurotransmission,
which
considered
primary
event
underlying
disease's
etiology.
However,
many
other
neuropathological
mechanisms
contribute
to
progression
and
clinical
symptoms
have
been
identified.
These
include
oxidative
stress,
neuroinflammation,
hippocampal
atrophy,
reduced
synaptic
plasticity
neurogenesis,
depletion
neurotrophic
factors,
dysfunction
hypothalamic-pituitary-adrenal
(HPA)
axis.
Current
therapeutic
options
often
unsatisfactory
associated
with
adverse
effects.
This
review
highlights
relevant
findings
concerning
role
flavonols,
a
ubiquitous
class
flavonoids
in
human
diet,
as
potential
antidepressant
agents.
In
general,
flavonols
be
both
an
effective
safe
option
management
depression,
largely
based
their
prominent
antioxidative
anti-inflammatory
Moreover,
preclinical
studies
provided
evidence
they
capable
restoring
neuroendocrine
control
HPA
axis,
promoting
alleviating
depressive-like
behavior.
Although
these
promising,
still
far
from
being
implemented
practice.
Hence,
further
needed
more
comprehensively
evaluate
respect
improvement
signs
depression.
Poultry Science,
Год журнала:
2023,
Номер
102(10), С. 102968 - 102968
Опубликована: Июль 27, 2023
This
study
discusses
the
effects
of
resveratrol
(RES)
on
productive
performance,
immune
function
and
intestinal
barrier
broiler
chickens
challenged
with
lipopolysaccharide
(LPS).
Two
hundred
forty
1-day-old
male
Arbor
Acres
broilers
were
randomly
divided
into
4
groups
6
replicates
each,
10
per
replicate.
experiment
used
a
2
×
factorial
design
dietary
factors
(basal
diets
or
basal
supplemented
400
mg/kg
RES
administered
from
d
1
to
21)
stress
(intraperitoneal
injection
0.5
BW
saline
LPS
at
16,
18
20
age).
The
results
showed
that
challenge
had
significant
adverse
effect
average
daily
gain
(ADG)
in
16
21
age
(P
<
0.05),
whereas
addition
diet
inhibited
LPS-induced
decrease
ADG
0.05).
also
alleviated
damage
broilers,
which
was
manifested
by
spleen
index
0.05)
recovery
serum
immunoglobulin
M
ileal
secretory
A
content
disrupts
inflammation,
mitigates
these
different
ways.
attenuated
reduction
villus
height
jejunum
ileum
caused
an
abnormal
increase
plasma
D-lactic
acid
levels
effectively
mitigated
resulted
mRNA
expression
occludin
mucosa
significantly
decreased
toll-like
receptor
4,
nuclear
factor
kappa-B
tumor
necrosis
alpha
tissue
stimulated
Taken
together,
this
shows
exerts
its
beneficial
alleviating
damage,
relieving
inflammation
thus
improving
growth
performance.
Food Chemistry Advances,
Год журнала:
2024,
Номер
4, С. 100725 - 100725
Опубликована: Май 22, 2024
To
optimize
food-derived
bioactive
components,
a
significant
concern
is
their
stability
and
bioavailability.
Quercetin,
well-known
polyphenol
found
in
onions,
has
garnered
attention
for
its
potential
bioactivity.
Recent
studies
have
illuminated
the
heightened
quercetin
content
sprouted
offering
unique
avenue
exploration.
The
well
documented
interaction
between
colonic
microflora
depicts
bioconversion
of
natural
bio
actives
by
gut
bacteria.
review
also
cites
prebiotic
activity
which
occurs
due
to
hydrolysis
during
sprouting
suggests
development
quercetin-based
nanoparticles
personalized
clinical
needs.
This
requires
considerable
research
on
use
with
focus
nanoscale
formulation,
scale-up,
regulatory
aspects
preventing
dysbiosis.To
explore
bioavailability
enhancement
implications
health,
this
comprehensive
examines
nutritional
aspects,
metabolic
pathways,
stability,
derived
from
onions.
Additionally,
it
investigates
interplay
bioefficacy
metabolites.
While
literature
exploring
onions
role
mitigating
lifestyle-related
disorders
limited,
aims
consolidate
existing
knowledge,
primary
diabetes
management
microbiota
modulation.
We
anticipate
that
insights
presented
article
will
contribute
strategies
optimizing
enhancing
realizing
health
promotion.
Ecotoxicology and Environmental Safety,
Год журнала:
2024,
Номер
282, С. 116692 - 116692
Опубликована: Июль 5, 2024
Viola
yedoensis
Makino
(Vy)
is
a
well-known
traditional
Chinese
medicine
widely
used
to
treat
inflammatory
diseases.
However,
the
regulatory
effects
of
dietary
Vy
supplementation
on
lipopolysaccharide
(LPS)-induced
intestinal
damage
in
broilers
and
underlying
molecular
mechanisms
remain
unclear.
In
this
study,
were
intraperitoneally
injected
with
1
mg/kg
LPS
days
17,
19
21
induce
damage.
at
0.5,
1.5
4.5
%
diet
was
administered
separately
for
investigate
potential
protective
against
LPS-induced
impairment
broilers.
improved
morphology
restored
growth
performance.
attenuated
inflammation
by
regulating
nuclear
factor
kappa
B
(NF-κB)
/
NLR
family
pyrin
domain-containing
3
(NLRP3)
signaling
pathway
inhibited
its
downstream
pro-inflammatory
levels.
addition,
relieved
oxidative
erythroid-2
related
2
(Nrf2)
mitogen-activated
protein
kinase
(MAPK)
antioxidant
enzyme
activity.
reduced
mitochondrial
apoptosis.
Furthermore,
alleviated
chickens
increasing
abundance
bacteria
(Lactobacillus
Romboutsia)
reducing
number
pathogenic
(unclassified_f_Ruminococcaceae,
unclassified_f_Oscillospiraceae
norank_f_norank_o_Clostridia_vadinBB60_group).
Overall,
effectively
ameliorated
NF-κB-NLRP3/Nrf2-MAPK
maintaining
microbiota
balance.
can
be
as
supplement
protect
