Multiomics-based Analysis of Key Genes, Metabolites and Pathways unveils Mechanism Associated with Social Rank in Chickens DOI Creative Commons

Mengqiao Zhao,

Limin Xing, Yushan Li

и другие.

Poultry Science, Год журнала: 2025, Номер unknown, С. 105192 - 105192

Опубликована: Апрель 1, 2025

Social rank plays a crucial role in shaping physiological, psychological and immune responses animals. Our previous study found that gut microbes short-chain fatty acids as well brain neurotransmitters are involved with the mechanism of social hierarchy. Nevertheless, how these metabolites interact to affect hierarchy chickens is not yet known. In this study, 40 hens were randomly divided into four groups at age 49 days, each hen was determined by 6 times according feeding competition tests. Then ranked 1/2 named High Rank (HSR, n = 8) 9/10 Low (LSR, 8). We use multiomics explore metabolites, neurotransmitters, transcriptome, related gene expression 91-day-old chickens, so better understand underpinning regulates pro-inflammatory genes significantly lower while anti-inflammatory factor spleen higher HSR than LSR (P<0.05). Besides, seven immune-related different amygdala between (P < 0.05). addition, AVP, RXFP3, VIP NKX2-1 associated through GABAergic neurons neuroactive ligand-receptor pathways, up-regulation 5-HT LSR. Genes SLC11A2 HMOX1 ferroptosis pathway influenced cecum metabolite l-glutamate tyrosine. While fumaric, l-glutamic 4-Oxoproline enriched "alanine, aspartate glutamate metabolism" "arginine biosynthesis". conclusion, affects immunity, which ranking show hens. TAP2, PLD4, P2RX7, ALDH9A1, SLC11A2, ADM, C3, VIP, NKX2-1, may play an important regulatory on neurons, pathways neuron, immune, stress behaviour, turn rank. Fumaric, 4-Oxoproline, regulate

Язык: Английский

Multiomics-based Analysis of Key Genes, Metabolites and Pathways unveils Mechanism Associated with Social Rank in Chickens DOI Creative Commons

Mengqiao Zhao,

Limin Xing, Yushan Li

и другие.

Poultry Science, Год журнала: 2025, Номер unknown, С. 105192 - 105192

Опубликована: Апрель 1, 2025

Social rank plays a crucial role in shaping physiological, psychological and immune responses animals. Our previous study found that gut microbes short-chain fatty acids as well brain neurotransmitters are involved with the mechanism of social hierarchy. Nevertheless, how these metabolites interact to affect hierarchy chickens is not yet known. In this study, 40 hens were randomly divided into four groups at age 49 days, each hen was determined by 6 times according feeding competition tests. Then ranked 1/2 named High Rank (HSR, n = 8) 9/10 Low (LSR, 8). We use multiomics explore metabolites, neurotransmitters, transcriptome, related gene expression 91-day-old chickens, so better understand underpinning regulates pro-inflammatory genes significantly lower while anti-inflammatory factor spleen higher HSR than LSR (P<0.05). Besides, seven immune-related different amygdala between (P < 0.05). addition, AVP, RXFP3, VIP NKX2-1 associated through GABAergic neurons neuroactive ligand-receptor pathways, up-regulation 5-HT LSR. Genes SLC11A2 HMOX1 ferroptosis pathway influenced cecum metabolite l-glutamate tyrosine. While fumaric, l-glutamic 4-Oxoproline enriched "alanine, aspartate glutamate metabolism" "arginine biosynthesis". conclusion, affects immunity, which ranking show hens. TAP2, PLD4, P2RX7, ALDH9A1, SLC11A2, ADM, C3, VIP, NKX2-1, may play an important regulatory on neurons, pathways neuron, immune, stress behaviour, turn rank. Fumaric, 4-Oxoproline, regulate

Язык: Английский

Процитировано

0