Use of a microbial endocrinology designed dopamine-producing probiotic to control gut neurochemical levels associated with the development of gut inflammation DOI Creative Commons
Mark Lyte,

Karrie M. Daniels,

J. Allen Byrd

и другие.

Poultry Science, Год журнала: 2025, Номер unknown, С. 105028 - 105028

Опубликована: Март 1, 2025

Neurochemicals, such as the catecholamines, serve critical regulators controlling immune response in pathogenesis of inflammation. Overproduction one these neurochemicals, namely norepinephrine, has been previously shown to occur concomitant development diet-induced gut As a pro-inflammatory neuroimmune modulatory chemical, norepinephrine can dysregulate In order ameliorate increased production we have utilized microbial endocrinology-based approach that utilizes an Enterococcus faecium probiotic produce anti-inflammatory neurochemical dopamine. present study, feed incorporated E. converts precursor L-dopa dopamine with high efficiency significant amounts within gastrointestinal tract. replicate broiler feeding trials utilizing non-starch polysaccharide (NSP) inflammation-inducing diet combination or not alone dopamine-producing probiotic, NSP induced large increase inflammation was abrogated groups fed faecium. Less, though still significant, amelioration achieved group only precursor. The report represents first use mechanistically influence another is intimately involved pathophysiology such, this study demonstrates Microbial Endocrinology-designed means by which prevent and/or control poultry.

Язык: Английский

Use of a microbial endocrinology designed dopamine-producing probiotic to control gut neurochemical levels associated with the development of gut inflammation DOI Creative Commons
Mark Lyte,

Karrie M. Daniels,

J. Allen Byrd

и другие.

Poultry Science, Год журнала: 2025, Номер unknown, С. 105028 - 105028

Опубликована: Март 1, 2025

Neurochemicals, such as the catecholamines, serve critical regulators controlling immune response in pathogenesis of inflammation. Overproduction one these neurochemicals, namely norepinephrine, has been previously shown to occur concomitant development diet-induced gut As a pro-inflammatory neuroimmune modulatory chemical, norepinephrine can dysregulate In order ameliorate increased production we have utilized microbial endocrinology-based approach that utilizes an Enterococcus faecium probiotic produce anti-inflammatory neurochemical dopamine. present study, feed incorporated E. converts precursor L-dopa dopamine with high efficiency significant amounts within gastrointestinal tract. replicate broiler feeding trials utilizing non-starch polysaccharide (NSP) inflammation-inducing diet combination or not alone dopamine-producing probiotic, NSP induced large increase inflammation was abrogated groups fed faecium. Less, though still significant, amelioration achieved group only precursor. The report represents first use mechanistically influence another is intimately involved pathophysiology such, this study demonstrates Microbial Endocrinology-designed means by which prevent and/or control poultry.

Язык: Английский

Процитировано

0