Children s Health Care,
Год журнала:
2023,
Номер
53(4), С. 350 - 373
Опубликована: Сен. 21, 2023
ABSTRACTChild
abuse,
neglect,
and
maltreatment
(CANM)
represents
a
significant
public
health
threat.
The
study's
goal
was
to
identify
factors
contributing
CANM
its
high
recurrence.
We
utilized
2019–2020
National
Child
Abuse
data
test
structural
equation
model
of
Child/Caregiver
Disability
variables;
Home
Instability
hypothesized
six-factor
with
as
mediator.
Of
1,221,176
victims,
29.9%
had
prior
victimization.
A
four-factor,
mediational
showed
strong
fit
(GFI
=
0.946,
NFI
0.919)
superior
alternative
models.
study
provides
framework
for
community
leaders
reduce
CANM.
Disclosure
statementNo
potential
conflict
interest
reported
by
the
author(s).Additional
informationFundingThe
author(s)
there
is
no
funding
associated
work
featured
in
this
article.
Complex Psychiatry,
Год журнала:
2024,
Номер
10(1-4), С. 71 - 107
Опубликована: Ноя. 18, 2024
Background:
Post-traumatic
stress
disorder
(PTSD)
can
occur
after
a
traumatic
event.
PTSD
is
characterized
by
nightmares,
flashbacks
and
avoidance
of
stressors.
It
currently
affects
2–8%
the
population,
with
military
personnel
particularly
susceptible.
Studies
show
that
environmental
stressors
induce
various
epigenetic
changes
shape
phenotype.
Despite
significant
impact
factors
on
symptoms
susceptibility,
they
have
not
been
widely
discussed
in
literature.
This
review
focuses
describing
mechanisms
PTSD,
especially
DNA
methylation,
chromatin
regulation,
noncoding
RNA.
Summary:
The
article
includes
relevant
studies
published
from
2013
to
2023,
excluding
non-English-language
or
insufficient
data.
investigated
gene
methylation
association
including
those
related
hypothalamic-pituitary-adrenal
axis,
brain-derived
neurotrophic
factor,
neurotransmitters,
immune
system
functioning,
as
well
role
histones
regulatory
RNAs.
Key
Messages:
Epigenetic
alterations
play
crucial
shaping
symptomatology,
long-term
outcomes,
highlighting
their
potential
important
markers
therapeutic
targets.
Understanding
these
aid
developing
clinical
strategies
better
predict,
prevent,
treat
PTSD.
However,
further
large-scale
longitudinal
are
needed
establish
temporal
relationship
between
onset
classify
other
mechanisms.
Children s Health Care,
Год журнала:
2023,
Номер
53(4), С. 350 - 373
Опубликована: Сен. 21, 2023
ABSTRACTChild
abuse,
neglect,
and
maltreatment
(CANM)
represents
a
significant
public
health
threat.
The
study's
goal
was
to
identify
factors
contributing
CANM
its
high
recurrence.
We
utilized
2019–2020
National
Child
Abuse
data
test
structural
equation
model
of
Child/Caregiver
Disability
variables;
Home
Instability
hypothesized
six-factor
with
as
mediator.
Of
1,221,176
victims,
29.9%
had
prior
victimization.
A
four-factor,
mediational
showed
strong
fit
(GFI
=
0.946,
NFI
0.919)
superior
alternative
models.
study
provides
framework
for
community
leaders
reduce
CANM.
Disclosure
statementNo
potential
conflict
interest
reported
by
the
author(s).Additional
informationFundingThe
author(s)
there
is
no
funding
associated
work
featured
in
this
article.
